Toxicological evaluation of the João da Costa e Associações® on Beagle dogs
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Brasileira de Farmacognosia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000100016 |
Resumo: | A toxicological study was performed in Beagle dogs treated for 180 days with the product João da Costa e Associações. Were used six males and six females distributed in control and treated groups (n=3). We used a dose of 566 mg/kg of the product according to preclinical study in rodents. The animals were weighed and evaluated by clinical and laboratory aspects. The product did not cause mortality or alter the normal behavior of animals, but interfered with the weight gain on males in the middle phase of the treatment. The group treated had a lower incidence of clinical abnormalities compared to control, checked by veterinary consultations. Laboratory data showed elevated blood glucose levels perhaps due to the high amount of sucrose present in the product; about the histopathological data no significant change was found. We conclude that the product Joao da Costa and Associações, at the dose tested, has low toxicity in Beagle dogs treated chronically. |
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Toxicological evaluation of the João da Costa e Associações® on Beagle dogsChondodendron platyphyllumEchites peltataGossypium herbaceumHimatanthus lancifoliusJoão da Costa e Associaçõespreclinical toxicologyA toxicological study was performed in Beagle dogs treated for 180 days with the product João da Costa e Associações. Were used six males and six females distributed in control and treated groups (n=3). We used a dose of 566 mg/kg of the product according to preclinical study in rodents. The animals were weighed and evaluated by clinical and laboratory aspects. The product did not cause mortality or alter the normal behavior of animals, but interfered with the weight gain on males in the middle phase of the treatment. The group treated had a lower incidence of clinical abnormalities compared to control, checked by veterinary consultations. Laboratory data showed elevated blood glucose levels perhaps due to the high amount of sucrose present in the product; about the histopathological data no significant change was found. We conclude that the product Joao da Costa and Associações, at the dose tested, has low toxicity in Beagle dogs treated chronically.Sociedade Brasileira de Farmacognosia2012-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000100016Revista Brasileira de Farmacognosia v.22 n.1 2012reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1590/S0102-695X2011005000208info:eu-repo/semantics/openAccessMagri,Ednéia G.Neves,Fernando T. A.Kaneshima,Edilson N.Silva,José C.Antunes,Vânia S.Costa,Fabiano P.Rocha,Orivaldo A.Tagliati,Carlos A.Marques,Luís C.eng2011-12-06T00:00:00Zoai:scielo:S0102-695X2012000100016Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2011-12-06T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false |
dc.title.none.fl_str_mv |
Toxicological evaluation of the João da Costa e Associações® on Beagle dogs |
title |
Toxicological evaluation of the João da Costa e Associações® on Beagle dogs |
spellingShingle |
Toxicological evaluation of the João da Costa e Associações® on Beagle dogs Magri,Ednéia G. Chondodendron platyphyllum Echites peltata Gossypium herbaceum Himatanthus lancifolius João da Costa e Associações preclinical toxicology |
title_short |
Toxicological evaluation of the João da Costa e Associações® on Beagle dogs |
title_full |
Toxicological evaluation of the João da Costa e Associações® on Beagle dogs |
title_fullStr |
Toxicological evaluation of the João da Costa e Associações® on Beagle dogs |
title_full_unstemmed |
Toxicological evaluation of the João da Costa e Associações® on Beagle dogs |
title_sort |
Toxicological evaluation of the João da Costa e Associações® on Beagle dogs |
author |
Magri,Ednéia G. |
author_facet |
Magri,Ednéia G. Neves,Fernando T. A. Kaneshima,Edilson N. Silva,José C. Antunes,Vânia S. Costa,Fabiano P. Rocha,Orivaldo A. Tagliati,Carlos A. Marques,Luís C. |
author_role |
author |
author2 |
Neves,Fernando T. A. Kaneshima,Edilson N. Silva,José C. Antunes,Vânia S. Costa,Fabiano P. Rocha,Orivaldo A. Tagliati,Carlos A. Marques,Luís C. |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Magri,Ednéia G. Neves,Fernando T. A. Kaneshima,Edilson N. Silva,José C. Antunes,Vânia S. Costa,Fabiano P. Rocha,Orivaldo A. Tagliati,Carlos A. Marques,Luís C. |
dc.subject.por.fl_str_mv |
Chondodendron platyphyllum Echites peltata Gossypium herbaceum Himatanthus lancifolius João da Costa e Associações preclinical toxicology |
topic |
Chondodendron platyphyllum Echites peltata Gossypium herbaceum Himatanthus lancifolius João da Costa e Associações preclinical toxicology |
description |
A toxicological study was performed in Beagle dogs treated for 180 days with the product João da Costa e Associações. Were used six males and six females distributed in control and treated groups (n=3). We used a dose of 566 mg/kg of the product according to preclinical study in rodents. The animals were weighed and evaluated by clinical and laboratory aspects. The product did not cause mortality or alter the normal behavior of animals, but interfered with the weight gain on males in the middle phase of the treatment. The group treated had a lower incidence of clinical abnormalities compared to control, checked by veterinary consultations. Laboratory data showed elevated blood glucose levels perhaps due to the high amount of sucrose present in the product; about the histopathological data no significant change was found. We conclude that the product Joao da Costa and Associações, at the dose tested, has low toxicity in Beagle dogs treated chronically. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-02-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000100016 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000100016 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0102-695X2011005000208 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
dc.source.none.fl_str_mv |
Revista Brasileira de Farmacognosia v.22 n.1 2012 reponame:Revista Brasileira de Farmacognosia (Online) instname:Sociedade Brasileira de Farmacognosia (SBFgnosia) instacron:SBFGNOSIA |
instname_str |
Sociedade Brasileira de Farmacognosia (SBFgnosia) |
instacron_str |
SBFGNOSIA |
institution |
SBFGNOSIA |
reponame_str |
Revista Brasileira de Farmacognosia (Online) |
collection |
Revista Brasileira de Farmacognosia (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia) |
repository.mail.fl_str_mv |
rbgnosia@ltf.ufpb.br |
_version_ |
1752122466579251200 |