Antidepressant effects of total tertiary alkaloid fraction of Cissampelos sympodialis Eichler in rodents

Detalhes bibliográficos
Autor(a) principal: Mendonça-Netto,Sueli
Data de Publicação: 2008
Outros Autores: Varela,Rogério W. B., Fechine,Madge F., Queiroga,Marcello N. G., Souto-Maior,Flávia N., Almeida,Reinaldo N.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Farmacognosia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2008000200004
Resumo: The purpose of the present study was to evaluate the effects of total tertiary alkaloid fraction (TTAF) of Cissampelos sympodialis Eichler (Menispermaceae) on two animal models of depression: a) forced swim test and b) reserpine test. Treatment of mice with TTAF (12.5 mg/kg) reduced the total immobility time. It also reversed the reserpine-induced hypothermia, demonstrating an antidepressant effect in both models. Additionally, TTAF treatment did not modify the ambulation and rearing evaluated in open field test in order to investigate if the immobility time reduction found in the forced swimming test was caused by locomotive activity stimulation. Since warifteine is one of the main alkaloids present in the TTAF of C. sympodialis, and it has inhibitory activity of the phosphodiesterase enzyme, it may be responsible by the antidepressant effect found in the fraction studied.
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spelling Antidepressant effects of total tertiary alkaloid fraction of Cissampelos sympodialis Eichler in rodentsCissampelos sympodialisMenispermaceaeantidepressant activitytotal tertiary alkaloids fractionThe purpose of the present study was to evaluate the effects of total tertiary alkaloid fraction (TTAF) of Cissampelos sympodialis Eichler (Menispermaceae) on two animal models of depression: a) forced swim test and b) reserpine test. Treatment of mice with TTAF (12.5 mg/kg) reduced the total immobility time. It also reversed the reserpine-induced hypothermia, demonstrating an antidepressant effect in both models. Additionally, TTAF treatment did not modify the ambulation and rearing evaluated in open field test in order to investigate if the immobility time reduction found in the forced swimming test was caused by locomotive activity stimulation. Since warifteine is one of the main alkaloids present in the TTAF of C. sympodialis, and it has inhibitory activity of the phosphodiesterase enzyme, it may be responsible by the antidepressant effect found in the fraction studied.Sociedade Brasileira de Farmacognosia2008-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2008000200004Revista Brasileira de Farmacognosia v.18 n.2 2008reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1590/S0102-695X2008000200004info:eu-repo/semantics/openAccessMendonça-Netto,SueliVarela,Rogério W. B.Fechine,Madge F.Queiroga,Marcello N. G.Souto-Maior,Flávia N.Almeida,Reinaldo N.eng2008-08-01T00:00:00Zoai:scielo:S0102-695X2008000200004Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2008-08-01T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false
dc.title.none.fl_str_mv Antidepressant effects of total tertiary alkaloid fraction of Cissampelos sympodialis Eichler in rodents
title Antidepressant effects of total tertiary alkaloid fraction of Cissampelos sympodialis Eichler in rodents
spellingShingle Antidepressant effects of total tertiary alkaloid fraction of Cissampelos sympodialis Eichler in rodents
Mendonça-Netto,Sueli
Cissampelos sympodialis
Menispermaceae
antidepressant activity
total tertiary alkaloids fraction
title_short Antidepressant effects of total tertiary alkaloid fraction of Cissampelos sympodialis Eichler in rodents
title_full Antidepressant effects of total tertiary alkaloid fraction of Cissampelos sympodialis Eichler in rodents
title_fullStr Antidepressant effects of total tertiary alkaloid fraction of Cissampelos sympodialis Eichler in rodents
title_full_unstemmed Antidepressant effects of total tertiary alkaloid fraction of Cissampelos sympodialis Eichler in rodents
title_sort Antidepressant effects of total tertiary alkaloid fraction of Cissampelos sympodialis Eichler in rodents
author Mendonça-Netto,Sueli
author_facet Mendonça-Netto,Sueli
Varela,Rogério W. B.
Fechine,Madge F.
Queiroga,Marcello N. G.
Souto-Maior,Flávia N.
Almeida,Reinaldo N.
author_role author
author2 Varela,Rogério W. B.
Fechine,Madge F.
Queiroga,Marcello N. G.
Souto-Maior,Flávia N.
Almeida,Reinaldo N.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Mendonça-Netto,Sueli
Varela,Rogério W. B.
Fechine,Madge F.
Queiroga,Marcello N. G.
Souto-Maior,Flávia N.
Almeida,Reinaldo N.
dc.subject.por.fl_str_mv Cissampelos sympodialis
Menispermaceae
antidepressant activity
total tertiary alkaloids fraction
topic Cissampelos sympodialis
Menispermaceae
antidepressant activity
total tertiary alkaloids fraction
description The purpose of the present study was to evaluate the effects of total tertiary alkaloid fraction (TTAF) of Cissampelos sympodialis Eichler (Menispermaceae) on two animal models of depression: a) forced swim test and b) reserpine test. Treatment of mice with TTAF (12.5 mg/kg) reduced the total immobility time. It also reversed the reserpine-induced hypothermia, demonstrating an antidepressant effect in both models. Additionally, TTAF treatment did not modify the ambulation and rearing evaluated in open field test in order to investigate if the immobility time reduction found in the forced swimming test was caused by locomotive activity stimulation. Since warifteine is one of the main alkaloids present in the TTAF of C. sympodialis, and it has inhibitory activity of the phosphodiesterase enzyme, it may be responsible by the antidepressant effect found in the fraction studied.
publishDate 2008
dc.date.none.fl_str_mv 2008-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2008000200004
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2008000200004
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-695X2008000200004
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
dc.source.none.fl_str_mv Revista Brasileira de Farmacognosia v.18 n.2 2008
reponame:Revista Brasileira de Farmacognosia (Online)
instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron:SBFGNOSIA
instname_str Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron_str SBFGNOSIA
institution SBFGNOSIA
reponame_str Revista Brasileira de Farmacognosia (Online)
collection Revista Brasileira de Farmacognosia (Online)
repository.name.fl_str_mv Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)
repository.mail.fl_str_mv rbgnosia@ltf.ufpb.br
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