Clinical safety evaluation of a tea containing Cissampelos sympodialis in healthy volunteers
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Publication Date: | 2015 |
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Format: | Article |
Language: | eng |
Source: | Revista Brasileira de Farmacognosia (Online) |
Download full: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2015000500491 |
Summary: | ABSTRACTCissampelos sympodialis Eichler, Menispermaceae, is widely used by Indian tribes and folk medicine to treat various inflammatory disorders, including asthma. Clinical toxicological trials were made with the tea of C. sympodialis, a medicinal plant. The study took place at Lauro Wanderley Hospital/UFPB-PB, where seventeen healthy volunteers were chosen, among those six men and eleven women who orally ingested, during four weeks uninterruptedly, 150 ml of the tea, once a day. Before the first ingestion and after the last one, the participants were subjected to clinical and laboratorial tests for their overall conditions in order to analyze the toxicity of the plant. The results demonstrated that the volunteers neither experience clinical nor laboratorial alterations, as well as no significant adverse effects, apart from little change detected in their hematological tests. Nevertheless, none demonstrated any pathological conditions, just alterations of the normal human being physiology. Therefore, it is concluded that these data complement that obtained during pre-clinical studies and confirm a low toxicity of this plant. |
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Clinical safety evaluation of a tea containing Cissampelos sympodialis in healthy volunteersClinicalCissampelos sympodialisMenispermaceaeTeaABSTRACTCissampelos sympodialis Eichler, Menispermaceae, is widely used by Indian tribes and folk medicine to treat various inflammatory disorders, including asthma. Clinical toxicological trials were made with the tea of C. sympodialis, a medicinal plant. The study took place at Lauro Wanderley Hospital/UFPB-PB, where seventeen healthy volunteers were chosen, among those six men and eleven women who orally ingested, during four weeks uninterruptedly, 150 ml of the tea, once a day. Before the first ingestion and after the last one, the participants were subjected to clinical and laboratorial tests for their overall conditions in order to analyze the toxicity of the plant. The results demonstrated that the volunteers neither experience clinical nor laboratorial alterations, as well as no significant adverse effects, apart from little change detected in their hematological tests. Nevertheless, none demonstrated any pathological conditions, just alterations of the normal human being physiology. Therefore, it is concluded that these data complement that obtained during pre-clinical studies and confirm a low toxicity of this plant.Sociedade Brasileira de Farmacognosia2015-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2015000500491Revista Brasileira de Farmacognosia v.25 n.5 2015reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1016/j.bjp.2015.06.009info:eu-repo/semantics/openAccessMangueira,Liane Franco BarrosRamalho,Luciana da Silva NunesLira,Andressa BritoRamalho,Josué do AmaralOliveira,Kardilandia MendesTorres,Aretuza Iolanda Pimentel de AlmeidaNascimento,Valério Marcelo Vasconcelos doLima,Caliandra Maria Bezerra LunaAragão,Cícero Flávio SoaresDiniz,Margareth de Fátima Formiga Meloeng2015-11-11T00:00:00Zoai:scielo:S0102-695X2015000500491Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2015-11-11T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false |
dc.title.none.fl_str_mv |
Clinical safety evaluation of a tea containing Cissampelos sympodialis in healthy volunteers |
title |
Clinical safety evaluation of a tea containing Cissampelos sympodialis in healthy volunteers |
spellingShingle |
Clinical safety evaluation of a tea containing Cissampelos sympodialis in healthy volunteers Mangueira,Liane Franco Barros Clinical Cissampelos sympodialis Menispermaceae Tea |
title_short |
Clinical safety evaluation of a tea containing Cissampelos sympodialis in healthy volunteers |
title_full |
Clinical safety evaluation of a tea containing Cissampelos sympodialis in healthy volunteers |
title_fullStr |
Clinical safety evaluation of a tea containing Cissampelos sympodialis in healthy volunteers |
title_full_unstemmed |
Clinical safety evaluation of a tea containing Cissampelos sympodialis in healthy volunteers |
title_sort |
Clinical safety evaluation of a tea containing Cissampelos sympodialis in healthy volunteers |
author |
Mangueira,Liane Franco Barros |
author_facet |
Mangueira,Liane Franco Barros Ramalho,Luciana da Silva Nunes Lira,Andressa Brito Ramalho,Josué do Amaral Oliveira,Kardilandia Mendes Torres,Aretuza Iolanda Pimentel de Almeida Nascimento,Valério Marcelo Vasconcelos do Lima,Caliandra Maria Bezerra Luna Aragão,Cícero Flávio Soares Diniz,Margareth de Fátima Formiga Melo |
author_role |
author |
author2 |
Ramalho,Luciana da Silva Nunes Lira,Andressa Brito Ramalho,Josué do Amaral Oliveira,Kardilandia Mendes Torres,Aretuza Iolanda Pimentel de Almeida Nascimento,Valério Marcelo Vasconcelos do Lima,Caliandra Maria Bezerra Luna Aragão,Cícero Flávio Soares Diniz,Margareth de Fátima Formiga Melo |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Mangueira,Liane Franco Barros Ramalho,Luciana da Silva Nunes Lira,Andressa Brito Ramalho,Josué do Amaral Oliveira,Kardilandia Mendes Torres,Aretuza Iolanda Pimentel de Almeida Nascimento,Valério Marcelo Vasconcelos do Lima,Caliandra Maria Bezerra Luna Aragão,Cícero Flávio Soares Diniz,Margareth de Fátima Formiga Melo |
dc.subject.por.fl_str_mv |
Clinical Cissampelos sympodialis Menispermaceae Tea |
topic |
Clinical Cissampelos sympodialis Menispermaceae Tea |
description |
ABSTRACTCissampelos sympodialis Eichler, Menispermaceae, is widely used by Indian tribes and folk medicine to treat various inflammatory disorders, including asthma. Clinical toxicological trials were made with the tea of C. sympodialis, a medicinal plant. The study took place at Lauro Wanderley Hospital/UFPB-PB, where seventeen healthy volunteers were chosen, among those six men and eleven women who orally ingested, during four weeks uninterruptedly, 150 ml of the tea, once a day. Before the first ingestion and after the last one, the participants were subjected to clinical and laboratorial tests for their overall conditions in order to analyze the toxicity of the plant. The results demonstrated that the volunteers neither experience clinical nor laboratorial alterations, as well as no significant adverse effects, apart from little change detected in their hematological tests. Nevertheless, none demonstrated any pathological conditions, just alterations of the normal human being physiology. Therefore, it is concluded that these data complement that obtained during pre-clinical studies and confirm a low toxicity of this plant. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2015000500491 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2015000500491 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.bjp.2015.06.009 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
dc.source.none.fl_str_mv |
Revista Brasileira de Farmacognosia v.25 n.5 2015 reponame:Revista Brasileira de Farmacognosia (Online) instname:Sociedade Brasileira de Farmacognosia (SBFgnosia) instacron:SBFGNOSIA |
instname_str |
Sociedade Brasileira de Farmacognosia (SBFgnosia) |
instacron_str |
SBFGNOSIA |
institution |
SBFGNOSIA |
reponame_str |
Revista Brasileira de Farmacognosia (Online) |
collection |
Revista Brasileira de Farmacognosia (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia) |
repository.mail.fl_str_mv |
rbgnosia@ltf.ufpb.br |
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1752122469618024448 |