Leishmanicidal activity of fractions rich in aporphine alkaloids from Amazonian Unonopsis species

Detalhes bibliográficos
Autor(a) principal: Silva,Felipe M. A. da
Data de Publicação: 2012
Outros Autores: Koolen,Hector H. F., Lima,Janaína P. S. de, Santos,Delvânia M. F., Jardim,Izaltina Silva, Souza,Afonso D. L. de, Pinheiro,Maria Lúcia Belém
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Farmacognosia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000600024
Resumo: In vitro evaluation of alkaloidal fractions of twigs, barks and leaves from two Unonopsis species, Unonopsis guatterioides R.E. Fr. and Unonopsis duckei R.E. Fr., Annonaceae, against promastigote forms of Leishmania amazonensis revealed these species as sources of substances with promising leishmanicidal potential. All alkaloidal fractions from twigs, barks and leaves of U. guatterioides were classified as highly active, with IC50 1.07, 1.90, and 2.79 mg/mL, respectively. Only the alkaloidal fraction from the twigs of U. duckei was classified as inactive.
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spelling Leishmanicidal activity of fractions rich in aporphine alkaloids from Amazonian Unonopsis speciesaporphine alkaloidsleishmanicidal activityUnonopsis duckeiUnonopsis guatterioidesIn vitro evaluation of alkaloidal fractions of twigs, barks and leaves from two Unonopsis species, Unonopsis guatterioides R.E. Fr. and Unonopsis duckei R.E. Fr., Annonaceae, against promastigote forms of Leishmania amazonensis revealed these species as sources of substances with promising leishmanicidal potential. All alkaloidal fractions from twigs, barks and leaves of U. guatterioides were classified as highly active, with IC50 1.07, 1.90, and 2.79 mg/mL, respectively. Only the alkaloidal fraction from the twigs of U. duckei was classified as inactive.Sociedade Brasileira de Farmacognosia2012-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000600024Revista Brasileira de Farmacognosia v.22 n.6 2012reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1590/S0102-695X2012005000103info:eu-repo/semantics/openAccessSilva,Felipe M. A. daKoolen,Hector H. F.Lima,Janaína P. S. deSantos,Delvânia M. F.Jardim,Izaltina SilvaSouza,Afonso D. L. dePinheiro,Maria Lúcia Belémeng2012-12-06T00:00:00Zoai:scielo:S0102-695X2012000600024Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2012-12-06T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false
dc.title.none.fl_str_mv Leishmanicidal activity of fractions rich in aporphine alkaloids from Amazonian Unonopsis species
title Leishmanicidal activity of fractions rich in aporphine alkaloids from Amazonian Unonopsis species
spellingShingle Leishmanicidal activity of fractions rich in aporphine alkaloids from Amazonian Unonopsis species
Silva,Felipe M. A. da
aporphine alkaloids
leishmanicidal activity
Unonopsis duckei
Unonopsis guatterioides
title_short Leishmanicidal activity of fractions rich in aporphine alkaloids from Amazonian Unonopsis species
title_full Leishmanicidal activity of fractions rich in aporphine alkaloids from Amazonian Unonopsis species
title_fullStr Leishmanicidal activity of fractions rich in aporphine alkaloids from Amazonian Unonopsis species
title_full_unstemmed Leishmanicidal activity of fractions rich in aporphine alkaloids from Amazonian Unonopsis species
title_sort Leishmanicidal activity of fractions rich in aporphine alkaloids from Amazonian Unonopsis species
author Silva,Felipe M. A. da
author_facet Silva,Felipe M. A. da
Koolen,Hector H. F.
Lima,Janaína P. S. de
Santos,Delvânia M. F.
Jardim,Izaltina Silva
Souza,Afonso D. L. de
Pinheiro,Maria Lúcia Belém
author_role author
author2 Koolen,Hector H. F.
Lima,Janaína P. S. de
Santos,Delvânia M. F.
Jardim,Izaltina Silva
Souza,Afonso D. L. de
Pinheiro,Maria Lúcia Belém
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Silva,Felipe M. A. da
Koolen,Hector H. F.
Lima,Janaína P. S. de
Santos,Delvânia M. F.
Jardim,Izaltina Silva
Souza,Afonso D. L. de
Pinheiro,Maria Lúcia Belém
dc.subject.por.fl_str_mv aporphine alkaloids
leishmanicidal activity
Unonopsis duckei
Unonopsis guatterioides
topic aporphine alkaloids
leishmanicidal activity
Unonopsis duckei
Unonopsis guatterioides
description In vitro evaluation of alkaloidal fractions of twigs, barks and leaves from two Unonopsis species, Unonopsis guatterioides R.E. Fr. and Unonopsis duckei R.E. Fr., Annonaceae, against promastigote forms of Leishmania amazonensis revealed these species as sources of substances with promising leishmanicidal potential. All alkaloidal fractions from twigs, barks and leaves of U. guatterioides were classified as highly active, with IC50 1.07, 1.90, and 2.79 mg/mL, respectively. Only the alkaloidal fraction from the twigs of U. duckei was classified as inactive.
publishDate 2012
dc.date.none.fl_str_mv 2012-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000600024
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000600024
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-695X2012005000103
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
dc.source.none.fl_str_mv Revista Brasileira de Farmacognosia v.22 n.6 2012
reponame:Revista Brasileira de Farmacognosia (Online)
instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron:SBFGNOSIA
instname_str Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron_str SBFGNOSIA
institution SBFGNOSIA
reponame_str Revista Brasileira de Farmacognosia (Online)
collection Revista Brasileira de Farmacognosia (Online)
repository.name.fl_str_mv Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)
repository.mail.fl_str_mv rbgnosia@ltf.ufpb.br
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