Polymorphisms on SSC15q21-q26 Containing QTL for reproduction in Swine and its association with litter size

Detalhes bibliográficos
Autor(a) principal: Du,Hongli
Data de Publicação: 2009
Outros Autores: Chen,Jing, Cui,Jianxun, Wang,Xiaoning, Zhang,Xiquan
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Genetics and Molecular Biology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572009000100010
Resumo: Several quantitative trait loci (QTL) for important reproductive traits (ovulation rate) have been identified on the porcine chromosome 15 (SSC15). To assist in the selection of positional candidate swine genes for these QTL on SSC15, twenty-one genes had already been assigned to SSC15 in a previous study in our lab, by using the radiation hybrid panel IMpRH. Further polymorphism studies were carried out on these positional candidate genes with four breeds of pigs (Duroc, Erhualian, Dahuabai and Landrace) harboring significant differences in reproduction traits. A total of nineteen polymorphisms were found in 21 genes. Among these, seven in six genes were used for association studies, whereby NRP2 polymorphism was found to be significantly (p < 0.05) associated with litter-size traits. NRP2 might be a candidate gene for pig-litter size based on its chromosome location (Du et al., 2006), significant association with litter-size traits and relationships with Sema and the VEGF super families.
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spelling Polymorphisms on SSC15q21-q26 Containing QTL for reproduction in Swine and its association with litter sizeporcinereproductive traitsNRP2candidate geneSeveral quantitative trait loci (QTL) for important reproductive traits (ovulation rate) have been identified on the porcine chromosome 15 (SSC15). To assist in the selection of positional candidate swine genes for these QTL on SSC15, twenty-one genes had already been assigned to SSC15 in a previous study in our lab, by using the radiation hybrid panel IMpRH. Further polymorphism studies were carried out on these positional candidate genes with four breeds of pigs (Duroc, Erhualian, Dahuabai and Landrace) harboring significant differences in reproduction traits. A total of nineteen polymorphisms were found in 21 genes. Among these, seven in six genes were used for association studies, whereby NRP2 polymorphism was found to be significantly (p < 0.05) associated with litter-size traits. NRP2 might be a candidate gene for pig-litter size based on its chromosome location (Du et al., 2006), significant association with litter-size traits and relationships with Sema and the VEGF super families.Sociedade Brasileira de Genética2009-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572009000100010Genetics and Molecular Biology v.32 n.1 2009reponame:Genetics and Molecular Biologyinstname:Sociedade Brasileira de Genética (SBG)instacron:SBG10.1590/S1415-47572009000100010info:eu-repo/semantics/openAccessDu,HongliChen,JingCui,JianxunWang,XiaoningZhang,Xiquaneng2009-02-10T00:00:00Zoai:scielo:S1415-47572009000100010Revistahttp://www.gmb.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||editor@gmb.org.br1678-46851415-4757opendoar:2009-02-10T00:00Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)false
dc.title.none.fl_str_mv Polymorphisms on SSC15q21-q26 Containing QTL for reproduction in Swine and its association with litter size
title Polymorphisms on SSC15q21-q26 Containing QTL for reproduction in Swine and its association with litter size
spellingShingle Polymorphisms on SSC15q21-q26 Containing QTL for reproduction in Swine and its association with litter size
Du,Hongli
porcine
reproductive traits
NRP2
candidate gene
title_short Polymorphisms on SSC15q21-q26 Containing QTL for reproduction in Swine and its association with litter size
title_full Polymorphisms on SSC15q21-q26 Containing QTL for reproduction in Swine and its association with litter size
title_fullStr Polymorphisms on SSC15q21-q26 Containing QTL for reproduction in Swine and its association with litter size
title_full_unstemmed Polymorphisms on SSC15q21-q26 Containing QTL for reproduction in Swine and its association with litter size
title_sort Polymorphisms on SSC15q21-q26 Containing QTL for reproduction in Swine and its association with litter size
author Du,Hongli
author_facet Du,Hongli
Chen,Jing
Cui,Jianxun
Wang,Xiaoning
Zhang,Xiquan
author_role author
author2 Chen,Jing
Cui,Jianxun
Wang,Xiaoning
Zhang,Xiquan
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Du,Hongli
Chen,Jing
Cui,Jianxun
Wang,Xiaoning
Zhang,Xiquan
dc.subject.por.fl_str_mv porcine
reproductive traits
NRP2
candidate gene
topic porcine
reproductive traits
NRP2
candidate gene
description Several quantitative trait loci (QTL) for important reproductive traits (ovulation rate) have been identified on the porcine chromosome 15 (SSC15). To assist in the selection of positional candidate swine genes for these QTL on SSC15, twenty-one genes had already been assigned to SSC15 in a previous study in our lab, by using the radiation hybrid panel IMpRH. Further polymorphism studies were carried out on these positional candidate genes with four breeds of pigs (Duroc, Erhualian, Dahuabai and Landrace) harboring significant differences in reproduction traits. A total of nineteen polymorphisms were found in 21 genes. Among these, seven in six genes were used for association studies, whereby NRP2 polymorphism was found to be significantly (p < 0.05) associated with litter-size traits. NRP2 might be a candidate gene for pig-litter size based on its chromosome location (Du et al., 2006), significant association with litter-size traits and relationships with Sema and the VEGF super families.
publishDate 2009
dc.date.none.fl_str_mv 2009-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572009000100010
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572009000100010
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1415-47572009000100010
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Genética
publisher.none.fl_str_mv Sociedade Brasileira de Genética
dc.source.none.fl_str_mv Genetics and Molecular Biology v.32 n.1 2009
reponame:Genetics and Molecular Biology
instname:Sociedade Brasileira de Genética (SBG)
instacron:SBG
instname_str Sociedade Brasileira de Genética (SBG)
instacron_str SBG
institution SBG
reponame_str Genetics and Molecular Biology
collection Genetics and Molecular Biology
repository.name.fl_str_mv Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)
repository.mail.fl_str_mv ||editor@gmb.org.br
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