Common BMI and diabetes-related genetic variants: A pilot study among indigenous people in the Brazilian Amazon
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Genetics and Molecular Biology |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572022000200103 |
Resumo: | Abstract This study was carried out to investigate the frequency of genetic variants related to body mass index (BMI) and type 2 diabetes (T2D) and evaluating the potential impact of risk alleles on susceptibility to these disorders in six indigenous peoples from Brazilian Amazon region. The majority of Fst values for pairwise population comparisons among the indigenous groups are low or moderate. The indigenous people show high values of differentiation with Africans, Europeans and Southeast Asians and moderate values with East Asian and American populations, as expected. The allelic frequencies among indigenous indicate that the majority of associations observed with T2D in continental populations can be replicated in native Amazonians. The genetic risk scores calculated for T2D in indigenous are high and similar to those calculated for Americans and East Asians, while the estimates obtained for obesity are low, probably due to the low frequencies of the risk allele of the FTO gene found in our samples. ADRB3-rs4994 and ABCC8-rs1799854 genes showed a significant association with BMI and waist circumference, and the KCNJ11-rs5219 gene with hyperglycemia. These results emphasize the importance of knowing the genetic variability underlying complex genetic diseases in indigenous peoples and the search for particular or rare variants. |
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Common BMI and diabetes-related genetic variants: A pilot study among indigenous people in the Brazilian AmazonT2DBMISNPAmerindiansBrazilianAbstract This study was carried out to investigate the frequency of genetic variants related to body mass index (BMI) and type 2 diabetes (T2D) and evaluating the potential impact of risk alleles on susceptibility to these disorders in six indigenous peoples from Brazilian Amazon region. The majority of Fst values for pairwise population comparisons among the indigenous groups are low or moderate. The indigenous people show high values of differentiation with Africans, Europeans and Southeast Asians and moderate values with East Asian and American populations, as expected. The allelic frequencies among indigenous indicate that the majority of associations observed with T2D in continental populations can be replicated in native Amazonians. The genetic risk scores calculated for T2D in indigenous are high and similar to those calculated for Americans and East Asians, while the estimates obtained for obesity are low, probably due to the low frequencies of the risk allele of the FTO gene found in our samples. ADRB3-rs4994 and ABCC8-rs1799854 genes showed a significant association with BMI and waist circumference, and the KCNJ11-rs5219 gene with hyperglycemia. These results emphasize the importance of knowing the genetic variability underlying complex genetic diseases in indigenous peoples and the search for particular or rare variants.Sociedade Brasileira de Genética2022-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572022000200103Genetics and Molecular Biology v.45 n.2 2022reponame:Genetics and Molecular Biologyinstname:Sociedade Brasileira de Genética (SBG)instacron:SBG10.1590/1678-4685-gmb-2021-0153info:eu-repo/semantics/openAccessDiniz,Isabela GuerreiroNoce,Rosilene Reis DellaPereira,Ana PaulaSilva,Aylla Núbia Lima Martins daSacuena,Eliene Rodrigues PutiraLemes,Renan BarbosaCardoso-Costa,Greice de LemosAraújo,Gilderlânio SantanaMachado,Jéssica Lígia PicançoFigueiredo,Fernanda Andreza de Pinho LottHümemeier,TábitaGuerreiro,João Fariaseng2022-05-09T00:00:00Zoai:scielo:S1415-47572022000200103Revistahttp://www.gmb.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||editor@gmb.org.br1678-46851415-4757opendoar:2022-05-09T00:00Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)false |
dc.title.none.fl_str_mv |
Common BMI and diabetes-related genetic variants: A pilot study among indigenous people in the Brazilian Amazon |
title |
Common BMI and diabetes-related genetic variants: A pilot study among indigenous people in the Brazilian Amazon |
spellingShingle |
Common BMI and diabetes-related genetic variants: A pilot study among indigenous people in the Brazilian Amazon Diniz,Isabela Guerreiro T2D BMI SNP Amerindians Brazilian |
title_short |
Common BMI and diabetes-related genetic variants: A pilot study among indigenous people in the Brazilian Amazon |
title_full |
Common BMI and diabetes-related genetic variants: A pilot study among indigenous people in the Brazilian Amazon |
title_fullStr |
Common BMI and diabetes-related genetic variants: A pilot study among indigenous people in the Brazilian Amazon |
title_full_unstemmed |
Common BMI and diabetes-related genetic variants: A pilot study among indigenous people in the Brazilian Amazon |
title_sort |
Common BMI and diabetes-related genetic variants: A pilot study among indigenous people in the Brazilian Amazon |
author |
Diniz,Isabela Guerreiro |
author_facet |
Diniz,Isabela Guerreiro Noce,Rosilene Reis Della Pereira,Ana Paula Silva,Aylla Núbia Lima Martins da Sacuena,Eliene Rodrigues Putira Lemes,Renan Barbosa Cardoso-Costa,Greice de Lemos Araújo,Gilderlânio Santana Machado,Jéssica Lígia Picanço Figueiredo,Fernanda Andreza de Pinho Lott Hümemeier,Tábita Guerreiro,João Farias |
author_role |
author |
author2 |
Noce,Rosilene Reis Della Pereira,Ana Paula Silva,Aylla Núbia Lima Martins da Sacuena,Eliene Rodrigues Putira Lemes,Renan Barbosa Cardoso-Costa,Greice de Lemos Araújo,Gilderlânio Santana Machado,Jéssica Lígia Picanço Figueiredo,Fernanda Andreza de Pinho Lott Hümemeier,Tábita Guerreiro,João Farias |
author2_role |
author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Diniz,Isabela Guerreiro Noce,Rosilene Reis Della Pereira,Ana Paula Silva,Aylla Núbia Lima Martins da Sacuena,Eliene Rodrigues Putira Lemes,Renan Barbosa Cardoso-Costa,Greice de Lemos Araújo,Gilderlânio Santana Machado,Jéssica Lígia Picanço Figueiredo,Fernanda Andreza de Pinho Lott Hümemeier,Tábita Guerreiro,João Farias |
dc.subject.por.fl_str_mv |
T2D BMI SNP Amerindians Brazilian |
topic |
T2D BMI SNP Amerindians Brazilian |
description |
Abstract This study was carried out to investigate the frequency of genetic variants related to body mass index (BMI) and type 2 diabetes (T2D) and evaluating the potential impact of risk alleles on susceptibility to these disorders in six indigenous peoples from Brazilian Amazon region. The majority of Fst values for pairwise population comparisons among the indigenous groups are low or moderate. The indigenous people show high values of differentiation with Africans, Europeans and Southeast Asians and moderate values with East Asian and American populations, as expected. The allelic frequencies among indigenous indicate that the majority of associations observed with T2D in continental populations can be replicated in native Amazonians. The genetic risk scores calculated for T2D in indigenous are high and similar to those calculated for Americans and East Asians, while the estimates obtained for obesity are low, probably due to the low frequencies of the risk allele of the FTO gene found in our samples. ADRB3-rs4994 and ABCC8-rs1799854 genes showed a significant association with BMI and waist circumference, and the KCNJ11-rs5219 gene with hyperglycemia. These results emphasize the importance of knowing the genetic variability underlying complex genetic diseases in indigenous peoples and the search for particular or rare variants. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572022000200103 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572022000200103 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1678-4685-gmb-2021-0153 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Genética |
publisher.none.fl_str_mv |
Sociedade Brasileira de Genética |
dc.source.none.fl_str_mv |
Genetics and Molecular Biology v.45 n.2 2022 reponame:Genetics and Molecular Biology instname:Sociedade Brasileira de Genética (SBG) instacron:SBG |
instname_str |
Sociedade Brasileira de Genética (SBG) |
instacron_str |
SBG |
institution |
SBG |
reponame_str |
Genetics and Molecular Biology |
collection |
Genetics and Molecular Biology |
repository.name.fl_str_mv |
Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG) |
repository.mail.fl_str_mv |
||editor@gmb.org.br |
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1752122390606774272 |