From abortion-inducing medications to Zika Virus Syndrome: 27 years experience of the First Teratogen Information Service in Latin America
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Genetics and Molecular Biology |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572019000200297 |
Resumo: | Abstract In 1990, the first Teratogen Information Service in Brazil (SIAT) was implemented in the Medical Genetics Service at Hospital de Clinicas de Porto Alegre. SIAT is a free-to-use information service both to health professionals and the general population, especially to women who are pregnant or planning pregnancy. The main objective of this paper is to present the activities of SIAT in its initial years (1990-2006), compared to those in the last decade (2007-2017). In addition we review the scientific contribution of SIAT in the field of human teratogenesis. Since 1990, SIAT received 10,533 calls. Use of medications were the main reason for concern, accounting for 74% of all questions, followed by other chemical exposures (occupational, cosmetics, environmental), and maternal infectious diseases. Among its main contributions to scientific knowledge was the collaboration for the identification of two new human teratogens: misoprostol in the 1990s and Zika virus in 2015/16. In conclusion, SIAT is still evolving, as is the Medical Genetics Service that hosts it. Through its 27 years of existence more than 300 undergraduate and graduate students have rotated at SIAT. Presently, SIAT is expanding the research to experimental teratogenesis and to investigation of molecular mechanisms of teratogens. |
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From abortion-inducing medications to Zika Virus Syndrome: 27 years experience of the First Teratogen Information Service in Latin AmericaTeratogenspregnancyzikathalidomidemisoprostolrubellaAbstract In 1990, the first Teratogen Information Service in Brazil (SIAT) was implemented in the Medical Genetics Service at Hospital de Clinicas de Porto Alegre. SIAT is a free-to-use information service both to health professionals and the general population, especially to women who are pregnant or planning pregnancy. The main objective of this paper is to present the activities of SIAT in its initial years (1990-2006), compared to those in the last decade (2007-2017). In addition we review the scientific contribution of SIAT in the field of human teratogenesis. Since 1990, SIAT received 10,533 calls. Use of medications were the main reason for concern, accounting for 74% of all questions, followed by other chemical exposures (occupational, cosmetics, environmental), and maternal infectious diseases. Among its main contributions to scientific knowledge was the collaboration for the identification of two new human teratogens: misoprostol in the 1990s and Zika virus in 2015/16. In conclusion, SIAT is still evolving, as is the Medical Genetics Service that hosts it. Through its 27 years of existence more than 300 undergraduate and graduate students have rotated at SIAT. Presently, SIAT is expanding the research to experimental teratogenesis and to investigation of molecular mechanisms of teratogens.Sociedade Brasileira de Genética2019-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572019000200297Genetics and Molecular Biology v.42 n.1 suppl.1 2019reponame:Genetics and Molecular Biologyinstname:Sociedade Brasileira de Genética (SBG)instacron:SBG10.1590/1678-4685-gmb-2018-0111info:eu-repo/semantics/openAccessSchüler-Faccini,LaviniaSanseverino,Maria Teresa VieiraAbeche,Alberto MantovaniVianna,Fernanda Sales LuizFraga,Lucas RosaRocha,Anastacia GuimaraesSilva,André Anjos daSouza,Paulo Ricardo Assis deHilgert,Artur HartmannBarbosa,Camila PocharskiKauppinem,Caroline GrassoMartins,Daniela FernandesSantos,Daniela SilvaColpes,Gabriel HenriqueEcco,GabrielaSilva,Helena Margot Flores Soares daPenteado,Louise PivaSantos,Tatiane doseng2019-07-12T00:00:00Zoai:scielo:S1415-47572019000200297Revistahttp://www.gmb.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||editor@gmb.org.br1678-46851415-4757opendoar:2019-07-12T00:00Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)false |
dc.title.none.fl_str_mv |
From abortion-inducing medications to Zika Virus Syndrome: 27 years experience of the First Teratogen Information Service in Latin America |
title |
From abortion-inducing medications to Zika Virus Syndrome: 27 years experience of the First Teratogen Information Service in Latin America |
spellingShingle |
From abortion-inducing medications to Zika Virus Syndrome: 27 years experience of the First Teratogen Information Service in Latin America Schüler-Faccini,Lavinia Teratogens pregnancy zika thalidomide misoprostol rubella |
title_short |
From abortion-inducing medications to Zika Virus Syndrome: 27 years experience of the First Teratogen Information Service in Latin America |
title_full |
From abortion-inducing medications to Zika Virus Syndrome: 27 years experience of the First Teratogen Information Service in Latin America |
title_fullStr |
From abortion-inducing medications to Zika Virus Syndrome: 27 years experience of the First Teratogen Information Service in Latin America |
title_full_unstemmed |
From abortion-inducing medications to Zika Virus Syndrome: 27 years experience of the First Teratogen Information Service in Latin America |
title_sort |
From abortion-inducing medications to Zika Virus Syndrome: 27 years experience of the First Teratogen Information Service in Latin America |
author |
Schüler-Faccini,Lavinia |
author_facet |
Schüler-Faccini,Lavinia Sanseverino,Maria Teresa Vieira Abeche,Alberto Mantovani Vianna,Fernanda Sales Luiz Fraga,Lucas Rosa Rocha,Anastacia Guimaraes Silva,André Anjos da Souza,Paulo Ricardo Assis de Hilgert,Artur Hartmann Barbosa,Camila Pocharski Kauppinem,Caroline Grasso Martins,Daniela Fernandes Santos,Daniela Silva Colpes,Gabriel Henrique Ecco,Gabriela Silva,Helena Margot Flores Soares da Penteado,Louise Piva Santos,Tatiane dos |
author_role |
author |
author2 |
Sanseverino,Maria Teresa Vieira Abeche,Alberto Mantovani Vianna,Fernanda Sales Luiz Fraga,Lucas Rosa Rocha,Anastacia Guimaraes Silva,André Anjos da Souza,Paulo Ricardo Assis de Hilgert,Artur Hartmann Barbosa,Camila Pocharski Kauppinem,Caroline Grasso Martins,Daniela Fernandes Santos,Daniela Silva Colpes,Gabriel Henrique Ecco,Gabriela Silva,Helena Margot Flores Soares da Penteado,Louise Piva Santos,Tatiane dos |
author2_role |
author author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Schüler-Faccini,Lavinia Sanseverino,Maria Teresa Vieira Abeche,Alberto Mantovani Vianna,Fernanda Sales Luiz Fraga,Lucas Rosa Rocha,Anastacia Guimaraes Silva,André Anjos da Souza,Paulo Ricardo Assis de Hilgert,Artur Hartmann Barbosa,Camila Pocharski Kauppinem,Caroline Grasso Martins,Daniela Fernandes Santos,Daniela Silva Colpes,Gabriel Henrique Ecco,Gabriela Silva,Helena Margot Flores Soares da Penteado,Louise Piva Santos,Tatiane dos |
dc.subject.por.fl_str_mv |
Teratogens pregnancy zika thalidomide misoprostol rubella |
topic |
Teratogens pregnancy zika thalidomide misoprostol rubella |
description |
Abstract In 1990, the first Teratogen Information Service in Brazil (SIAT) was implemented in the Medical Genetics Service at Hospital de Clinicas de Porto Alegre. SIAT is a free-to-use information service both to health professionals and the general population, especially to women who are pregnant or planning pregnancy. The main objective of this paper is to present the activities of SIAT in its initial years (1990-2006), compared to those in the last decade (2007-2017). In addition we review the scientific contribution of SIAT in the field of human teratogenesis. Since 1990, SIAT received 10,533 calls. Use of medications were the main reason for concern, accounting for 74% of all questions, followed by other chemical exposures (occupational, cosmetics, environmental), and maternal infectious diseases. Among its main contributions to scientific knowledge was the collaboration for the identification of two new human teratogens: misoprostol in the 1990s and Zika virus in 2015/16. In conclusion, SIAT is still evolving, as is the Medical Genetics Service that hosts it. Through its 27 years of existence more than 300 undergraduate and graduate students have rotated at SIAT. Presently, SIAT is expanding the research to experimental teratogenesis and to investigation of molecular mechanisms of teratogens. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572019000200297 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572019000200297 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1678-4685-gmb-2018-0111 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Genética |
publisher.none.fl_str_mv |
Sociedade Brasileira de Genética |
dc.source.none.fl_str_mv |
Genetics and Molecular Biology v.42 n.1 suppl.1 2019 reponame:Genetics and Molecular Biology instname:Sociedade Brasileira de Genética (SBG) instacron:SBG |
instname_str |
Sociedade Brasileira de Genética (SBG) |
instacron_str |
SBG |
institution |
SBG |
reponame_str |
Genetics and Molecular Biology |
collection |
Genetics and Molecular Biology |
repository.name.fl_str_mv |
Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG) |
repository.mail.fl_str_mv |
||editor@gmb.org.br |
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1752122389287665664 |