A rapid detection method for PAI-1 promoter insertion/deletion polymorphism (4G/5G)

Detalhes bibliográficos
Autor(a) principal: Annichino-Bizzacchi,Joyce M.
Data de Publicação: 1998
Outros Autores: Pugliese,Luciana, Arruda,Valder R.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Genetics and Molecular Biology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47571998000300004
Resumo: Plasminogen activator inhibitor-1 (PAI-1) is an important inhibitor of fibrinolysis, and increased levels of PAI-1 are associated with atheroma and myocardial infarction. A common 4G/5G insertion/deletion polymorphism located in the promoter region of PAI-1 gene has been described associated with PAI-1 activity in plasma levels. Genotyping of this polymorphism is commonly conducted with an allele-specific oligonucleotide melting technique. In the present study, we describe a quick, easy method for genotyping 4G/5G polymorphism in the promoter region of the PAI-1 gene.
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spelling A rapid detection method for PAI-1 promoter insertion/deletion polymorphism (4G/5G)Plasminogen activator inhibitor-1 (PAI-1) is an important inhibitor of fibrinolysis, and increased levels of PAI-1 are associated with atheroma and myocardial infarction. A common 4G/5G insertion/deletion polymorphism located in the promoter region of PAI-1 gene has been described associated with PAI-1 activity in plasma levels. Genotyping of this polymorphism is commonly conducted with an allele-specific oligonucleotide melting technique. In the present study, we describe a quick, easy method for genotyping 4G/5G polymorphism in the promoter region of the PAI-1 gene.Sociedade Brasileira de Genética1998-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47571998000300004Genetics and Molecular Biology v.21 n.3 1998reponame:Genetics and Molecular Biologyinstname:Sociedade Brasileira de Genética (SBG)instacron:SBG10.1590/S1415-47571998000300004info:eu-repo/semantics/openAccessAnnichino-Bizzacchi,Joyce M.Pugliese,LucianaArruda,Valder R.eng1999-02-23T00:00:00Zoai:scielo:S1415-47571998000300004Revistahttp://www.gmb.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||editor@gmb.org.br1678-46851415-4757opendoar:1999-02-23T00:00Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)false
dc.title.none.fl_str_mv A rapid detection method for PAI-1 promoter insertion/deletion polymorphism (4G/5G)
title A rapid detection method for PAI-1 promoter insertion/deletion polymorphism (4G/5G)
spellingShingle A rapid detection method for PAI-1 promoter insertion/deletion polymorphism (4G/5G)
Annichino-Bizzacchi,Joyce M.
title_short A rapid detection method for PAI-1 promoter insertion/deletion polymorphism (4G/5G)
title_full A rapid detection method for PAI-1 promoter insertion/deletion polymorphism (4G/5G)
title_fullStr A rapid detection method for PAI-1 promoter insertion/deletion polymorphism (4G/5G)
title_full_unstemmed A rapid detection method for PAI-1 promoter insertion/deletion polymorphism (4G/5G)
title_sort A rapid detection method for PAI-1 promoter insertion/deletion polymorphism (4G/5G)
author Annichino-Bizzacchi,Joyce M.
author_facet Annichino-Bizzacchi,Joyce M.
Pugliese,Luciana
Arruda,Valder R.
author_role author
author2 Pugliese,Luciana
Arruda,Valder R.
author2_role author
author
dc.contributor.author.fl_str_mv Annichino-Bizzacchi,Joyce M.
Pugliese,Luciana
Arruda,Valder R.
description Plasminogen activator inhibitor-1 (PAI-1) is an important inhibitor of fibrinolysis, and increased levels of PAI-1 are associated with atheroma and myocardial infarction. A common 4G/5G insertion/deletion polymorphism located in the promoter region of PAI-1 gene has been described associated with PAI-1 activity in plasma levels. Genotyping of this polymorphism is commonly conducted with an allele-specific oligonucleotide melting technique. In the present study, we describe a quick, easy method for genotyping 4G/5G polymorphism in the promoter region of the PAI-1 gene.
publishDate 1998
dc.date.none.fl_str_mv 1998-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47571998000300004
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47571998000300004
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1415-47571998000300004
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Genética
publisher.none.fl_str_mv Sociedade Brasileira de Genética
dc.source.none.fl_str_mv Genetics and Molecular Biology v.21 n.3 1998
reponame:Genetics and Molecular Biology
instname:Sociedade Brasileira de Genética (SBG)
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instname_str Sociedade Brasileira de Genética (SBG)
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institution SBG
reponame_str Genetics and Molecular Biology
collection Genetics and Molecular Biology
repository.name.fl_str_mv Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)
repository.mail.fl_str_mv ||editor@gmb.org.br
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