An immunogenetic view of COVID-19
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Genetics and Molecular Biology |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572021000200316 |
Resumo: | Abstract Meeting the challenges brought by the COVID-19 pandemic requires an interdisciplinary approach. In this context, integrating knowledge of immune function with an understanding of how genetic variation influences the nature of immunity is a key challenge. Immunogenetics can help explain the heterogeneity of susceptibility and protection to the viral infection and disease progression. Here, we review the knowledge developed so far, discussing fundamental genes for triggering the innate and adaptive immune responses associated with a viral infection, especially with the SARS-CoV-2 mechanisms. We emphasize the role of the HLA and KIR genes, discussing what has been uncovered about their role in COVID-19 and addressing methodological challenges of studying these genes. Finally, we comment on questions that arise when studying admixed populations, highlighting the case of Brazil. We argue that the interplay between immunology and an understanding of genetic associations can provide an important contribution to our knowledge of COVID-19. |
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Genetics and Molecular Biology |
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An immunogenetic view of COVID-19ImmunogeneticsCOVID-19SARS-CoV-2HLAKIRAbstract Meeting the challenges brought by the COVID-19 pandemic requires an interdisciplinary approach. In this context, integrating knowledge of immune function with an understanding of how genetic variation influences the nature of immunity is a key challenge. Immunogenetics can help explain the heterogeneity of susceptibility and protection to the viral infection and disease progression. Here, we review the knowledge developed so far, discussing fundamental genes for triggering the innate and adaptive immune responses associated with a viral infection, especially with the SARS-CoV-2 mechanisms. We emphasize the role of the HLA and KIR genes, discussing what has been uncovered about their role in COVID-19 and addressing methodological challenges of studying these genes. Finally, we comment on questions that arise when studying admixed populations, highlighting the case of Brazil. We argue that the interplay between immunology and an understanding of genetic associations can provide an important contribution to our knowledge of COVID-19.Sociedade Brasileira de Genética2021-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572021000200316Genetics and Molecular Biology v.44 n.1 suppl.1 2021reponame:Genetics and Molecular Biologyinstname:Sociedade Brasileira de Genética (SBG)instacron:SBG10.1590/1678-4685-gmb-2021-0036info:eu-repo/semantics/openAccessAguiar,Vitor R. C.Augusto,Danillo G.Castelli,Erick C.Hollenbach,Jill A.Meyer,DiogoNunes,KellyPetzl-Erler,Maria Luizaeng2021-08-23T00:00:00Zoai:scielo:S1415-47572021000200316Revistahttp://www.gmb.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||editor@gmb.org.br1678-46851415-4757opendoar:2021-08-23T00:00Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)false |
dc.title.none.fl_str_mv |
An immunogenetic view of COVID-19 |
title |
An immunogenetic view of COVID-19 |
spellingShingle |
An immunogenetic view of COVID-19 Aguiar,Vitor R. C. Immunogenetics COVID-19 SARS-CoV-2 HLA KIR |
title_short |
An immunogenetic view of COVID-19 |
title_full |
An immunogenetic view of COVID-19 |
title_fullStr |
An immunogenetic view of COVID-19 |
title_full_unstemmed |
An immunogenetic view of COVID-19 |
title_sort |
An immunogenetic view of COVID-19 |
author |
Aguiar,Vitor R. C. |
author_facet |
Aguiar,Vitor R. C. Augusto,Danillo G. Castelli,Erick C. Hollenbach,Jill A. Meyer,Diogo Nunes,Kelly Petzl-Erler,Maria Luiza |
author_role |
author |
author2 |
Augusto,Danillo G. Castelli,Erick C. Hollenbach,Jill A. Meyer,Diogo Nunes,Kelly Petzl-Erler,Maria Luiza |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Aguiar,Vitor R. C. Augusto,Danillo G. Castelli,Erick C. Hollenbach,Jill A. Meyer,Diogo Nunes,Kelly Petzl-Erler,Maria Luiza |
dc.subject.por.fl_str_mv |
Immunogenetics COVID-19 SARS-CoV-2 HLA KIR |
topic |
Immunogenetics COVID-19 SARS-CoV-2 HLA KIR |
description |
Abstract Meeting the challenges brought by the COVID-19 pandemic requires an interdisciplinary approach. In this context, integrating knowledge of immune function with an understanding of how genetic variation influences the nature of immunity is a key challenge. Immunogenetics can help explain the heterogeneity of susceptibility and protection to the viral infection and disease progression. Here, we review the knowledge developed so far, discussing fundamental genes for triggering the innate and adaptive immune responses associated with a viral infection, especially with the SARS-CoV-2 mechanisms. We emphasize the role of the HLA and KIR genes, discussing what has been uncovered about their role in COVID-19 and addressing methodological challenges of studying these genes. Finally, we comment on questions that arise when studying admixed populations, highlighting the case of Brazil. We argue that the interplay between immunology and an understanding of genetic associations can provide an important contribution to our knowledge of COVID-19. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572021000200316 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572021000200316 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1678-4685-gmb-2021-0036 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Genética |
publisher.none.fl_str_mv |
Sociedade Brasileira de Genética |
dc.source.none.fl_str_mv |
Genetics and Molecular Biology v.44 n.1 suppl.1 2021 reponame:Genetics and Molecular Biology instname:Sociedade Brasileira de Genética (SBG) instacron:SBG |
instname_str |
Sociedade Brasileira de Genética (SBG) |
instacron_str |
SBG |
institution |
SBG |
reponame_str |
Genetics and Molecular Biology |
collection |
Genetics and Molecular Biology |
repository.name.fl_str_mv |
Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG) |
repository.mail.fl_str_mv |
||editor@gmb.org.br |
_version_ |
1752122390220898304 |