Quinolone resistance and ornithine decarboxylation activity in lactose-negative Escherichia coli

• Autor(a) principal: Gomig,Franciane
• Data de Publicação: 2015
• Outros Autores: Galvão,Carolina Weigert, Freitas,Denis Leandro de, Labas,Larissa, Etto,Rafael Mazer, Esmerino,Luiz Antonio, Lima,Marcelo Andrade de, Appel,Marcia Helena, Zanata,Silvio Marques, Steffens,Maria Berenice Reynaud, Nader,Helena Bonciani, Silveira,Rafael Bertoni da
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Brazilian Journal of Microbiology
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822015000300753
• topic: ODC; gyrA; parC; uropathogenic

Quinolones and fluoroquinolones are widely used to treat uropathogenic Escherichia coli infections. Bacterial resistance to these antimicrobials primarily involves mutations in gyrA and parC genes. To date, no studies have examined the potential relationship between biochemical characteristics and quinolone resistance in uropathogenic E. coli strains. The present work analyzed the quinolone sensitivity and biochemical activities of fifty-eight lactose-negative uropathogenic E. coli strains. A high percentage of the isolates (48.3%) was found to be resistant to at least one of the tested quinolones, and DNA sequencing revealed quinolone resistant determining region gyrA and parC mutations in the multi-resistant isolates. Statistical analyses suggested that the lack of ornithine decarboxylase (ODC) activity is correlated with quinolone resistance. Despite the low number of isolates examined, this is the first study correlating these characteristics in lactose-negative E. coli isolates.