Lactoferrin, chitosan and Melaleuca alternifolia-natural products that show promise in candidiasis treatment

Detalhes bibliográficos
Autor(a) principal: Felipe,Lorena de Oliveira
Data de Publicação: 2018
Outros Autores: Silva Júnior,Willer Ferreira da, Araújo,Katialaine Corrêa de, Fabrino,Daniela Leite
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Microbiology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822018000200212
Resumo: Abstract The evolution of microorganisms resistant to many medicines has become a major challenge for the scientific community around the world. Motivated by the gravity of such a situation, the World Health Organization released a report in 2014 with the aim of providing updated information on this critical scenario. Among the most worrying microorganisms, species from the genus Candida have exhibited a high rate of resistance to antifungal drugs. Therefore, the objective of this review is to show that the use of natural products (extracts or isolated biomolecules), along with conventional antifungal therapy, can be a very promising strategy to overcome microbial multiresistance. Some promising alternatives are essential oils of Melaleuca alternifolia (mainly composed of terpinen-4-ol, a type of monoterpene), lactoferrin (a peptide isolated from milk) and chitosan (a copolymer from chitin). Such products have great potential to increase antifungal therapy efficacy, mitigate side effects and provide a wide range of action in antifungal therapy.
id SBM-1_ce549dbf9d286ff6f489a2ffeb92e5a8
oai_identifier_str oai:scielo:S1517-83822018000200212
network_acronym_str SBM-1
network_name_str Brazilian Journal of Microbiology
repository_id_str
spelling Lactoferrin, chitosan and Melaleuca alternifolia-natural products that show promise in candidiasis treatmentCandidaLactoferrinMelaleuca alternifoliaChitosanNatural productsAbstract The evolution of microorganisms resistant to many medicines has become a major challenge for the scientific community around the world. Motivated by the gravity of such a situation, the World Health Organization released a report in 2014 with the aim of providing updated information on this critical scenario. Among the most worrying microorganisms, species from the genus Candida have exhibited a high rate of resistance to antifungal drugs. Therefore, the objective of this review is to show that the use of natural products (extracts or isolated biomolecules), along with conventional antifungal therapy, can be a very promising strategy to overcome microbial multiresistance. Some promising alternatives are essential oils of Melaleuca alternifolia (mainly composed of terpinen-4-ol, a type of monoterpene), lactoferrin (a peptide isolated from milk) and chitosan (a copolymer from chitin). Such products have great potential to increase antifungal therapy efficacy, mitigate side effects and provide a wide range of action in antifungal therapy.Sociedade Brasileira de Microbiologia2018-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822018000200212Brazilian Journal of Microbiology v.49 n.2 2018reponame:Brazilian Journal of Microbiologyinstname:Sociedade Brasileira de Microbiologia (SBM)instacron:SBM10.1016/j.bjm.2017.05.008info:eu-repo/semantics/openAccessFelipe,Lorena de OliveiraSilva Júnior,Willer Ferreira daAraújo,Katialaine Corrêa deFabrino,Daniela Leiteeng2018-04-17T00:00:00Zoai:scielo:S1517-83822018000200212Revistahttps://www.scielo.br/j/bjm/ONGhttps://old.scielo.br/oai/scielo-oai.phpbjm@sbmicrobiologia.org.br||mbmartin@usp.br1678-44051517-8382opendoar:2018-04-17T00:00Brazilian Journal of Microbiology - Sociedade Brasileira de Microbiologia (SBM)false
dc.title.none.fl_str_mv Lactoferrin, chitosan and Melaleuca alternifolia-natural products that show promise in candidiasis treatment
title Lactoferrin, chitosan and Melaleuca alternifolia-natural products that show promise in candidiasis treatment
spellingShingle Lactoferrin, chitosan and Melaleuca alternifolia-natural products that show promise in candidiasis treatment
Felipe,Lorena de Oliveira
Candida
Lactoferrin
Melaleuca alternifolia
Chitosan
Natural products
title_short Lactoferrin, chitosan and Melaleuca alternifolia-natural products that show promise in candidiasis treatment
title_full Lactoferrin, chitosan and Melaleuca alternifolia-natural products that show promise in candidiasis treatment
title_fullStr Lactoferrin, chitosan and Melaleuca alternifolia-natural products that show promise in candidiasis treatment
title_full_unstemmed Lactoferrin, chitosan and Melaleuca alternifolia-natural products that show promise in candidiasis treatment
title_sort Lactoferrin, chitosan and Melaleuca alternifolia-natural products that show promise in candidiasis treatment
author Felipe,Lorena de Oliveira
author_facet Felipe,Lorena de Oliveira
Silva Júnior,Willer Ferreira da
Araújo,Katialaine Corrêa de
Fabrino,Daniela Leite
author_role author
author2 Silva Júnior,Willer Ferreira da
Araújo,Katialaine Corrêa de
Fabrino,Daniela Leite
author2_role author
author
author
dc.contributor.author.fl_str_mv Felipe,Lorena de Oliveira
Silva Júnior,Willer Ferreira da
Araújo,Katialaine Corrêa de
Fabrino,Daniela Leite
dc.subject.por.fl_str_mv Candida
Lactoferrin
Melaleuca alternifolia
Chitosan
Natural products
topic Candida
Lactoferrin
Melaleuca alternifolia
Chitosan
Natural products
description Abstract The evolution of microorganisms resistant to many medicines has become a major challenge for the scientific community around the world. Motivated by the gravity of such a situation, the World Health Organization released a report in 2014 with the aim of providing updated information on this critical scenario. Among the most worrying microorganisms, species from the genus Candida have exhibited a high rate of resistance to antifungal drugs. Therefore, the objective of this review is to show that the use of natural products (extracts or isolated biomolecules), along with conventional antifungal therapy, can be a very promising strategy to overcome microbial multiresistance. Some promising alternatives are essential oils of Melaleuca alternifolia (mainly composed of terpinen-4-ol, a type of monoterpene), lactoferrin (a peptide isolated from milk) and chitosan (a copolymer from chitin). Such products have great potential to increase antifungal therapy efficacy, mitigate side effects and provide a wide range of action in antifungal therapy.
publishDate 2018
dc.date.none.fl_str_mv 2018-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822018000200212
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822018000200212
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1016/j.bjm.2017.05.008
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Microbiologia
publisher.none.fl_str_mv Sociedade Brasileira de Microbiologia
dc.source.none.fl_str_mv Brazilian Journal of Microbiology v.49 n.2 2018
reponame:Brazilian Journal of Microbiology
instname:Sociedade Brasileira de Microbiologia (SBM)
instacron:SBM
instname_str Sociedade Brasileira de Microbiologia (SBM)
instacron_str SBM
institution SBM
reponame_str Brazilian Journal of Microbiology
collection Brazilian Journal of Microbiology
repository.name.fl_str_mv Brazilian Journal of Microbiology - Sociedade Brasileira de Microbiologia (SBM)
repository.mail.fl_str_mv bjm@sbmicrobiologia.org.br||mbmartin@usp.br
_version_ 1752122209331052544

Registros relacionados