Selection of 5-fluorocytosine-resistant mutants from an Aspergillus niger citric acid-producing strain

Detalhes bibliográficos
Autor(a) principal: Conte,Ana Paula de F.
Data de Publicação: 2003
Outros Autores: Marin,José M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Microbiology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822003000100001
Resumo: Mutants of Aspergillus niger N402, induced by UV mutagenesis, were selected and tested for resistance or sensitivity to 5-fluorocytosine. Some mutants showed increased citric acid production, which did not correlate with the intracellular amount of protein or ammonium ion. The resistance to 5-fluorocytosine proved to be a rational approach for isolation of new mutants with improved production of citric acid. The best mutant (FR13) accumulated double the amount of citric acid produced by the parental strain.
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spelling Selection of 5-fluorocytosine-resistant mutants from an Aspergillus niger citric acid-producing strainAspergillus nigercitric acid5-fluorocytosineMutants of Aspergillus niger N402, induced by UV mutagenesis, were selected and tested for resistance or sensitivity to 5-fluorocytosine. Some mutants showed increased citric acid production, which did not correlate with the intracellular amount of protein or ammonium ion. The resistance to 5-fluorocytosine proved to be a rational approach for isolation of new mutants with improved production of citric acid. The best mutant (FR13) accumulated double the amount of citric acid produced by the parental strain.Sociedade Brasileira de Microbiologia2003-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822003000100001Brazilian Journal of Microbiology v.34 n.1 2003reponame:Brazilian Journal of Microbiologyinstname:Sociedade Brasileira de Microbiologia (SBM)instacron:SBM10.1590/S1517-83822003000100001info:eu-repo/semantics/openAccessConte,Ana Paula de F.Marin,José M.eng2003-06-30T00:00:00Zoai:scielo:S1517-83822003000100001Revistahttps://www.scielo.br/j/bjm/ONGhttps://old.scielo.br/oai/scielo-oai.phpbjm@sbmicrobiologia.org.br||mbmartin@usp.br1678-44051517-8382opendoar:2003-06-30T00:00Brazilian Journal of Microbiology - Sociedade Brasileira de Microbiologia (SBM)false
dc.title.none.fl_str_mv Selection of 5-fluorocytosine-resistant mutants from an Aspergillus niger citric acid-producing strain
title Selection of 5-fluorocytosine-resistant mutants from an Aspergillus niger citric acid-producing strain
spellingShingle Selection of 5-fluorocytosine-resistant mutants from an Aspergillus niger citric acid-producing strain
Conte,Ana Paula de F.
Aspergillus niger
citric acid
5-fluorocytosine
title_short Selection of 5-fluorocytosine-resistant mutants from an Aspergillus niger citric acid-producing strain
title_full Selection of 5-fluorocytosine-resistant mutants from an Aspergillus niger citric acid-producing strain
title_fullStr Selection of 5-fluorocytosine-resistant mutants from an Aspergillus niger citric acid-producing strain
title_full_unstemmed Selection of 5-fluorocytosine-resistant mutants from an Aspergillus niger citric acid-producing strain
title_sort Selection of 5-fluorocytosine-resistant mutants from an Aspergillus niger citric acid-producing strain
author Conte,Ana Paula de F.
author_facet Conte,Ana Paula de F.
Marin,José M.
author_role author
author2 Marin,José M.
author2_role author
dc.contributor.author.fl_str_mv Conte,Ana Paula de F.
Marin,José M.
dc.subject.por.fl_str_mv Aspergillus niger
citric acid
5-fluorocytosine
topic Aspergillus niger
citric acid
5-fluorocytosine
description Mutants of Aspergillus niger N402, induced by UV mutagenesis, were selected and tested for resistance or sensitivity to 5-fluorocytosine. Some mutants showed increased citric acid production, which did not correlate with the intracellular amount of protein or ammonium ion. The resistance to 5-fluorocytosine proved to be a rational approach for isolation of new mutants with improved production of citric acid. The best mutant (FR13) accumulated double the amount of citric acid produced by the parental strain.
publishDate 2003
dc.date.none.fl_str_mv 2003-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822003000100001
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822003000100001
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1517-83822003000100001
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Microbiologia
publisher.none.fl_str_mv Sociedade Brasileira de Microbiologia
dc.source.none.fl_str_mv Brazilian Journal of Microbiology v.34 n.1 2003
reponame:Brazilian Journal of Microbiology
instname:Sociedade Brasileira de Microbiologia (SBM)
instacron:SBM
instname_str Sociedade Brasileira de Microbiologia (SBM)
instacron_str SBM
institution SBM
reponame_str Brazilian Journal of Microbiology
collection Brazilian Journal of Microbiology
repository.name.fl_str_mv Brazilian Journal of Microbiology - Sociedade Brasileira de Microbiologia (SBM)
repository.mail.fl_str_mv bjm@sbmicrobiologia.org.br||mbmartin@usp.br
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