COMPARISON OF THE EFFICACY OF LOSARTAN, HYDROCORTISONE AND ACETYLSALICYLIC ACID (ASA) IN PREVENTING THE DEVELOPMENT OF FIBROUS SCAR TISSUE IN SKELETAL MUSCLE
Autor(a) principal: | |
---|---|
Data de Publicação: | 2018 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista brasileira de medicina do esporte (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-86922018000600418 |
Resumo: | ABSTRACT Objective: To analyze fibrous scar tissue inhibition capacity with the use of losartan, hydrocortisone and acetylsalicylic acid. Method: The sample consisted of 120 male heterogeneic Wistar rats with a muscle laceration model. The rats were divided into four groups of 30 animals each: control group, losartan group, ASA group and hydrocortisone group. The animals were anesthetized and a 2.5 cm longitudinal incision was made in the left thoracolumbar paravertebral region. The muscles were subjected to a Grade III lesion caused by applying Kelly hemostatic forceps for 60 seconds, followed by sectioning with scissors. The skin was sutured with 3-0 nylon monofilament thread. The animals were placed in individual cages with plenty of food and water. The losartan group received losartan diluted in water at a dose of 0.1 mg/mL (10 mg/kg/day), the ASA Group received a 3 mg/mL ASA solution (300 mg/kg/day), and the hydrocortisone group received a 0.2 mg/mL hydrocortisone solution (20 mg/kg/day). Results: The control, losartan, hydrocortisone and aspirin groups had a fibrotic area of 0.95 ± 0.35 mm, 0.55 ± 0.34 mm, 0.93 ± 0.33 mm, and 0.66 ± 0.36 mm, respectively. We observed a significantly smaller fibrotic area in the losartan group compared to the control (p=0.01) and hydrocortisone (p=0.01) groups. There were no significant differences among the other groups. Conclusion: The healing of striated skeletal muscle produced less fibrous scar tissue when exposed to losartan in comparison to the control group or the hydrocortisone group. Level of Evidence I; Randomized double-blind placebo-controlled study. |
id |
SBMEE-1_ed2d7dc8ad61f115f58c114fb6e0f68c |
---|---|
oai_identifier_str |
oai:scielo:S1517-86922018000600418 |
network_acronym_str |
SBMEE-1 |
network_name_str |
Revista brasileira de medicina do esporte (Online) |
repository_id_str |
|
spelling |
COMPARISON OF THE EFFICACY OF LOSARTAN, HYDROCORTISONE AND ACETYLSALICYLIC ACID (ASA) IN PREVENTING THE DEVELOPMENT OF FIBROUS SCAR TISSUE IN SKELETAL MUSCLERegenerationTransforming growth factor betaLosartanSatellite cells, skeletal muscleMuscle, striatedABSTRACT Objective: To analyze fibrous scar tissue inhibition capacity with the use of losartan, hydrocortisone and acetylsalicylic acid. Method: The sample consisted of 120 male heterogeneic Wistar rats with a muscle laceration model. The rats were divided into four groups of 30 animals each: control group, losartan group, ASA group and hydrocortisone group. The animals were anesthetized and a 2.5 cm longitudinal incision was made in the left thoracolumbar paravertebral region. The muscles were subjected to a Grade III lesion caused by applying Kelly hemostatic forceps for 60 seconds, followed by sectioning with scissors. The skin was sutured with 3-0 nylon monofilament thread. The animals were placed in individual cages with plenty of food and water. The losartan group received losartan diluted in water at a dose of 0.1 mg/mL (10 mg/kg/day), the ASA Group received a 3 mg/mL ASA solution (300 mg/kg/day), and the hydrocortisone group received a 0.2 mg/mL hydrocortisone solution (20 mg/kg/day). Results: The control, losartan, hydrocortisone and aspirin groups had a fibrotic area of 0.95 ± 0.35 mm, 0.55 ± 0.34 mm, 0.93 ± 0.33 mm, and 0.66 ± 0.36 mm, respectively. We observed a significantly smaller fibrotic area in the losartan group compared to the control (p=0.01) and hydrocortisone (p=0.01) groups. There were no significant differences among the other groups. Conclusion: The healing of striated skeletal muscle produced less fibrous scar tissue when exposed to losartan in comparison to the control group or the hydrocortisone group. Level of Evidence I; Randomized double-blind placebo-controlled study.Sociedade Brasileira de Medicina do Exercício e do Esporte2018-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-86922018000600418Revista Brasileira de Medicina do Esporte v.24 n.6 2018reponame:Revista brasileira de medicina do esporte (Online)instname:Sociedade Brasileira de Medicina do Exercício e do Esporte (SBMEE)instacron:SBMEE10.1590/1517-869220182406149841info:eu-repo/semantics/openAccessMelo-Silva Junior,OtavioNunes,Cristiana BuzelinCorrêa,Tchalton AmadorSilva,Marilia F.Freitas,Laurice B.Alberti,Luiz Ronaldoeng2018-11-30T00:00:00Zoai:scielo:S1517-86922018000600418Revistahttp://www.scielo.br/rbmeONGhttps://old.scielo.br/oai/scielo-oai.php||revista@medicinadoesporte.org.br1806-99401517-8692opendoar:2018-11-30T00:00Revista brasileira de medicina do esporte (Online) - Sociedade Brasileira de Medicina do Exercício e do Esporte (SBMEE)false |
dc.title.none.fl_str_mv |
COMPARISON OF THE EFFICACY OF LOSARTAN, HYDROCORTISONE AND ACETYLSALICYLIC ACID (ASA) IN PREVENTING THE DEVELOPMENT OF FIBROUS SCAR TISSUE IN SKELETAL MUSCLE |
title |
COMPARISON OF THE EFFICACY OF LOSARTAN, HYDROCORTISONE AND ACETYLSALICYLIC ACID (ASA) IN PREVENTING THE DEVELOPMENT OF FIBROUS SCAR TISSUE IN SKELETAL MUSCLE |
spellingShingle |
COMPARISON OF THE EFFICACY OF LOSARTAN, HYDROCORTISONE AND ACETYLSALICYLIC ACID (ASA) IN PREVENTING THE DEVELOPMENT OF FIBROUS SCAR TISSUE IN SKELETAL MUSCLE Melo-Silva Junior,Otavio Regeneration Transforming growth factor beta Losartan Satellite cells, skeletal muscle Muscle, striated |
title_short |
COMPARISON OF THE EFFICACY OF LOSARTAN, HYDROCORTISONE AND ACETYLSALICYLIC ACID (ASA) IN PREVENTING THE DEVELOPMENT OF FIBROUS SCAR TISSUE IN SKELETAL MUSCLE |
title_full |
COMPARISON OF THE EFFICACY OF LOSARTAN, HYDROCORTISONE AND ACETYLSALICYLIC ACID (ASA) IN PREVENTING THE DEVELOPMENT OF FIBROUS SCAR TISSUE IN SKELETAL MUSCLE |
title_fullStr |
COMPARISON OF THE EFFICACY OF LOSARTAN, HYDROCORTISONE AND ACETYLSALICYLIC ACID (ASA) IN PREVENTING THE DEVELOPMENT OF FIBROUS SCAR TISSUE IN SKELETAL MUSCLE |
title_full_unstemmed |
COMPARISON OF THE EFFICACY OF LOSARTAN, HYDROCORTISONE AND ACETYLSALICYLIC ACID (ASA) IN PREVENTING THE DEVELOPMENT OF FIBROUS SCAR TISSUE IN SKELETAL MUSCLE |
title_sort |
COMPARISON OF THE EFFICACY OF LOSARTAN, HYDROCORTISONE AND ACETYLSALICYLIC ACID (ASA) IN PREVENTING THE DEVELOPMENT OF FIBROUS SCAR TISSUE IN SKELETAL MUSCLE |
author |
Melo-Silva Junior,Otavio |
author_facet |
Melo-Silva Junior,Otavio Nunes,Cristiana Buzelin Corrêa,Tchalton Amador Silva,Marilia F. Freitas,Laurice B. Alberti,Luiz Ronaldo |
author_role |
author |
author2 |
Nunes,Cristiana Buzelin Corrêa,Tchalton Amador Silva,Marilia F. Freitas,Laurice B. Alberti,Luiz Ronaldo |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Melo-Silva Junior,Otavio Nunes,Cristiana Buzelin Corrêa,Tchalton Amador Silva,Marilia F. Freitas,Laurice B. Alberti,Luiz Ronaldo |
dc.subject.por.fl_str_mv |
Regeneration Transforming growth factor beta Losartan Satellite cells, skeletal muscle Muscle, striated |
topic |
Regeneration Transforming growth factor beta Losartan Satellite cells, skeletal muscle Muscle, striated |
description |
ABSTRACT Objective: To analyze fibrous scar tissue inhibition capacity with the use of losartan, hydrocortisone and acetylsalicylic acid. Method: The sample consisted of 120 male heterogeneic Wistar rats with a muscle laceration model. The rats were divided into four groups of 30 animals each: control group, losartan group, ASA group and hydrocortisone group. The animals were anesthetized and a 2.5 cm longitudinal incision was made in the left thoracolumbar paravertebral region. The muscles were subjected to a Grade III lesion caused by applying Kelly hemostatic forceps for 60 seconds, followed by sectioning with scissors. The skin was sutured with 3-0 nylon monofilament thread. The animals were placed in individual cages with plenty of food and water. The losartan group received losartan diluted in water at a dose of 0.1 mg/mL (10 mg/kg/day), the ASA Group received a 3 mg/mL ASA solution (300 mg/kg/day), and the hydrocortisone group received a 0.2 mg/mL hydrocortisone solution (20 mg/kg/day). Results: The control, losartan, hydrocortisone and aspirin groups had a fibrotic area of 0.95 ± 0.35 mm, 0.55 ± 0.34 mm, 0.93 ± 0.33 mm, and 0.66 ± 0.36 mm, respectively. We observed a significantly smaller fibrotic area in the losartan group compared to the control (p=0.01) and hydrocortisone (p=0.01) groups. There were no significant differences among the other groups. Conclusion: The healing of striated skeletal muscle produced less fibrous scar tissue when exposed to losartan in comparison to the control group or the hydrocortisone group. Level of Evidence I; Randomized double-blind placebo-controlled study. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-86922018000600418 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-86922018000600418 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1517-869220182406149841 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Medicina do Exercício e do Esporte |
publisher.none.fl_str_mv |
Sociedade Brasileira de Medicina do Exercício e do Esporte |
dc.source.none.fl_str_mv |
Revista Brasileira de Medicina do Esporte v.24 n.6 2018 reponame:Revista brasileira de medicina do esporte (Online) instname:Sociedade Brasileira de Medicina do Exercício e do Esporte (SBMEE) instacron:SBMEE |
instname_str |
Sociedade Brasileira de Medicina do Exercício e do Esporte (SBMEE) |
instacron_str |
SBMEE |
institution |
SBMEE |
reponame_str |
Revista brasileira de medicina do esporte (Online) |
collection |
Revista brasileira de medicina do esporte (Online) |
repository.name.fl_str_mv |
Revista brasileira de medicina do esporte (Online) - Sociedade Brasileira de Medicina do Exercício e do Esporte (SBMEE) |
repository.mail.fl_str_mv |
||revista@medicinadoesporte.org.br |
_version_ |
1752122236360196096 |