Vaccination of C57BL/10 mice against cutaneous leishmaniasis using killed promastigotes of different strains and species of Leishmania

Detalhes bibliográficos
Autor(a) principal: Mayrink,Wilson
Data de Publicação: 2002
Outros Autores: Santos,Gilmara Cristina dos, Toledo,Vicente de Paulo Coelho Peixoto de, Guimarães,Tânia Mara Pinto Dabés, Machado-Coelho,George Luis Lins, Genaro,Odair, Costa,Carlos Alberto da
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista da Sociedade Brasileira de Medicina Tropical
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822002000200001
Resumo: Antigenic extracts from five Leishmania stocks were used to vaccinate C57BL/10 mice. The Leishvacin® and PH8 monovalent vaccine yielded the highest IFN-gamma levels in the supernatants of spleen cell culture from vaccinated animals. Each single strain immunized group showed evidence of protective immunity six months after the challenge with promastigotes of Leishmania (Leishmania) amazonensis. No differences were detected between the vaccinated groups. It can be concluded that vaccines composed of single Leishmania stocks can provide protection to C57BL/10 mice against L. (L.) amazonensis infection.
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spelling Vaccination of C57BL/10 mice against cutaneous leishmaniasis using killed promastigotes of different strains and species of LeishmaniaLeishmaniaVaccineInterferon-gammaInterleukin-4Antigenic extracts from five Leishmania stocks were used to vaccinate C57BL/10 mice. The Leishvacin® and PH8 monovalent vaccine yielded the highest IFN-gamma levels in the supernatants of spleen cell culture from vaccinated animals. Each single strain immunized group showed evidence of protective immunity six months after the challenge with promastigotes of Leishmania (Leishmania) amazonensis. No differences were detected between the vaccinated groups. It can be concluded that vaccines composed of single Leishmania stocks can provide protection to C57BL/10 mice against L. (L.) amazonensis infection.Sociedade Brasileira de Medicina Tropical - SBMT2002-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822002000200001Revista da Sociedade Brasileira de Medicina Tropical v.35 n.2 2002reponame:Revista da Sociedade Brasileira de Medicina Tropicalinstname:Sociedade Brasileira de Medicina Tropical (SBMT)instacron:SBMT10.1590/S0037-86822002000200001info:eu-repo/semantics/openAccessMayrink,WilsonSantos,Gilmara Cristina dosToledo,Vicente de Paulo Coelho Peixoto deGuimarães,Tânia Mara Pinto DabésMachado-Coelho,George Luis LinsGenaro,OdairCosta,Carlos Alberto daeng2002-05-07T00:00:00Zoai:scielo:S0037-86822002000200001Revistahttps://www.sbmt.org.br/portal/revista/ONGhttps://old.scielo.br/oai/scielo-oai.php||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br1678-98490037-8682opendoar:2002-05-07T00:00Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT)false
dc.title.none.fl_str_mv Vaccination of C57BL/10 mice against cutaneous leishmaniasis using killed promastigotes of different strains and species of Leishmania
title Vaccination of C57BL/10 mice against cutaneous leishmaniasis using killed promastigotes of different strains and species of Leishmania
spellingShingle Vaccination of C57BL/10 mice against cutaneous leishmaniasis using killed promastigotes of different strains and species of Leishmania
Mayrink,Wilson
Leishmania
Vaccine
Interferon-gamma
Interleukin-4
title_short Vaccination of C57BL/10 mice against cutaneous leishmaniasis using killed promastigotes of different strains and species of Leishmania
title_full Vaccination of C57BL/10 mice against cutaneous leishmaniasis using killed promastigotes of different strains and species of Leishmania
title_fullStr Vaccination of C57BL/10 mice against cutaneous leishmaniasis using killed promastigotes of different strains and species of Leishmania
title_full_unstemmed Vaccination of C57BL/10 mice against cutaneous leishmaniasis using killed promastigotes of different strains and species of Leishmania
title_sort Vaccination of C57BL/10 mice against cutaneous leishmaniasis using killed promastigotes of different strains and species of Leishmania
author Mayrink,Wilson
author_facet Mayrink,Wilson
Santos,Gilmara Cristina dos
Toledo,Vicente de Paulo Coelho Peixoto de
Guimarães,Tânia Mara Pinto Dabés
Machado-Coelho,George Luis Lins
Genaro,Odair
Costa,Carlos Alberto da
author_role author
author2 Santos,Gilmara Cristina dos
Toledo,Vicente de Paulo Coelho Peixoto de
Guimarães,Tânia Mara Pinto Dabés
Machado-Coelho,George Luis Lins
Genaro,Odair
Costa,Carlos Alberto da
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Mayrink,Wilson
Santos,Gilmara Cristina dos
Toledo,Vicente de Paulo Coelho Peixoto de
Guimarães,Tânia Mara Pinto Dabés
Machado-Coelho,George Luis Lins
Genaro,Odair
Costa,Carlos Alberto da
dc.subject.por.fl_str_mv Leishmania
Vaccine
Interferon-gamma
Interleukin-4
topic Leishmania
Vaccine
Interferon-gamma
Interleukin-4
description Antigenic extracts from five Leishmania stocks were used to vaccinate C57BL/10 mice. The Leishvacin® and PH8 monovalent vaccine yielded the highest IFN-gamma levels in the supernatants of spleen cell culture from vaccinated animals. Each single strain immunized group showed evidence of protective immunity six months after the challenge with promastigotes of Leishmania (Leishmania) amazonensis. No differences were detected between the vaccinated groups. It can be concluded that vaccines composed of single Leishmania stocks can provide protection to C57BL/10 mice against L. (L.) amazonensis infection.
publishDate 2002
dc.date.none.fl_str_mv 2002-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822002000200001
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822002000200001
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0037-86822002000200001
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical - SBMT
publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical - SBMT
dc.source.none.fl_str_mv Revista da Sociedade Brasileira de Medicina Tropical v.35 n.2 2002
reponame:Revista da Sociedade Brasileira de Medicina Tropical
instname:Sociedade Brasileira de Medicina Tropical (SBMT)
instacron:SBMT
instname_str Sociedade Brasileira de Medicina Tropical (SBMT)
instacron_str SBMT
institution SBMT
reponame_str Revista da Sociedade Brasileira de Medicina Tropical
collection Revista da Sociedade Brasileira de Medicina Tropical
repository.name.fl_str_mv Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT)
repository.mail.fl_str_mv ||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br
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