Genetic polymorphism for IFNγ +874T/A in patients with acute toxoplasmosis

• Autor(a) principal: Neves,Elizabeth de Souza
• Data de Publicação: 2012
• Outros Autores: Curi,André Luis Land, Albuquerque,Maira Cavalcanti de, Palhano-Silva,Cassius Schnel, Silva,Laura Berriel da, Bueno,Wendy Fernandes, Amendoeira,Maria Regina dos Reis, Bonecini-Almeida,Maria da Gloria, Fernandes,Octavio
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Revista da Sociedade Brasileira de Medicina Tropical
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822012000600020
• topic: Toxoplasmosis; Interferon gamma; Retinochoroiditis

INTRODUCTION: A single nucleotide polymorphism (SNP) in the gene encoding gamma interferon influences its production and is associated with severity of infectious diseases. This study aimed to evaluate the association of IFNγ+874T/A SNP with duration of disease, morbidity, and development of retinochoroiditis in acute toxoplasmosis. METHODS: A case-control study was conducted among 30 patients and 90 controls. RESULTS: Although statistical associations were not confirmed, A-allele was more common among retinochoroiditis cases and prolonged illness, while T-allele was more frequent in severe disease. CONCLUSIONS: Despite few cases, the results could indicate a relation between IFNγ+874T/A single nucleotide polymorphism and clinical manifestations of toxoplasmosis.