Immunophenotyping of circulating T cells in a mucosal leishmaniasis patient coinfected with HIV

Detalhes bibliográficos
Autor(a) principal: Castellano,Lúcio Roberto
Data de Publicação: 2011
Outros Autores: Llaguno,Mauricio, Silva,Marcos Vinícius, Machado,Juliana Reis, Correia,Dalmo, Silva-Vergara,Mario León, Rodrigues,Virmondes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista da Sociedade Brasileira de Medicina Tropical
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822011000400025
Resumo: HIV coinfection modifies the clinical course of leishmaniasis by promoting a Th2 pattern of cytokine production. However, little information is available regarding the lymphocytic response in untreated coinfected patients. This work presents the immunophenotyping of Leishmania-stimulated T cells from a treatment-naÏve HIV+ patient with ML. Leishmania braziliensis antigens induced CD69 expression on CD3+CD4+ and CD3+CD8+ cells. It also increased IL-4 intracellular staining on CD3+CD4+GATA3- population and decreased the percentage of CD3+CD4+IL-17+ cells. This suggests that modulations in the IL-4R/STAT6 pathway and the Th17 population may serve as parasitic evasion mechanisms in HIV/ML. Further studies are required to confirm these results.
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spelling Immunophenotyping of circulating T cells in a mucosal leishmaniasis patient coinfected with HIVMucosal leishmaniasisLeishmania braziliensisHIV coinfectionHIV coinfection modifies the clinical course of leishmaniasis by promoting a Th2 pattern of cytokine production. However, little information is available regarding the lymphocytic response in untreated coinfected patients. This work presents the immunophenotyping of Leishmania-stimulated T cells from a treatment-naÏve HIV+ patient with ML. Leishmania braziliensis antigens induced CD69 expression on CD3+CD4+ and CD3+CD8+ cells. It also increased IL-4 intracellular staining on CD3+CD4+GATA3- population and decreased the percentage of CD3+CD4+IL-17+ cells. This suggests that modulations in the IL-4R/STAT6 pathway and the Th17 population may serve as parasitic evasion mechanisms in HIV/ML. Further studies are required to confirm these results.Sociedade Brasileira de Medicina Tropical - SBMT2011-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822011000400025Revista da Sociedade Brasileira de Medicina Tropical v.44 n.4 2011reponame:Revista da Sociedade Brasileira de Medicina Tropicalinstname:Sociedade Brasileira de Medicina Tropical (SBMT)instacron:SBMT10.1590/S0037-86822011000400025info:eu-repo/semantics/openAccessCastellano,Lúcio RobertoLlaguno,MauricioSilva,Marcos ViníciusMachado,Juliana ReisCorreia,DalmoSilva-Vergara,Mario LeónRodrigues,Virmondeseng2016-09-30T00:00:00Zoai:scielo:S0037-86822011000400025Revistahttps://www.sbmt.org.br/portal/revista/ONGhttps://old.scielo.br/oai/scielo-oai.php||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br1678-98490037-8682opendoar:2016-09-30T00:00Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT)false
dc.title.none.fl_str_mv Immunophenotyping of circulating T cells in a mucosal leishmaniasis patient coinfected with HIV
title Immunophenotyping of circulating T cells in a mucosal leishmaniasis patient coinfected with HIV
spellingShingle Immunophenotyping of circulating T cells in a mucosal leishmaniasis patient coinfected with HIV
Castellano,Lúcio Roberto
Mucosal leishmaniasis
Leishmania braziliensis
HIV coinfection
title_short Immunophenotyping of circulating T cells in a mucosal leishmaniasis patient coinfected with HIV
title_full Immunophenotyping of circulating T cells in a mucosal leishmaniasis patient coinfected with HIV
title_fullStr Immunophenotyping of circulating T cells in a mucosal leishmaniasis patient coinfected with HIV
title_full_unstemmed Immunophenotyping of circulating T cells in a mucosal leishmaniasis patient coinfected with HIV
title_sort Immunophenotyping of circulating T cells in a mucosal leishmaniasis patient coinfected with HIV
author Castellano,Lúcio Roberto
author_facet Castellano,Lúcio Roberto
Llaguno,Mauricio
Silva,Marcos Vinícius
Machado,Juliana Reis
Correia,Dalmo
Silva-Vergara,Mario León
Rodrigues,Virmondes
author_role author
author2 Llaguno,Mauricio
Silva,Marcos Vinícius
Machado,Juliana Reis
Correia,Dalmo
Silva-Vergara,Mario León
Rodrigues,Virmondes
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Castellano,Lúcio Roberto
Llaguno,Mauricio
Silva,Marcos Vinícius
Machado,Juliana Reis
Correia,Dalmo
Silva-Vergara,Mario León
Rodrigues,Virmondes
dc.subject.por.fl_str_mv Mucosal leishmaniasis
Leishmania braziliensis
HIV coinfection
topic Mucosal leishmaniasis
Leishmania braziliensis
HIV coinfection
description HIV coinfection modifies the clinical course of leishmaniasis by promoting a Th2 pattern of cytokine production. However, little information is available regarding the lymphocytic response in untreated coinfected patients. This work presents the immunophenotyping of Leishmania-stimulated T cells from a treatment-naÏve HIV+ patient with ML. Leishmania braziliensis antigens induced CD69 expression on CD3+CD4+ and CD3+CD8+ cells. It also increased IL-4 intracellular staining on CD3+CD4+GATA3- population and decreased the percentage of CD3+CD4+IL-17+ cells. This suggests that modulations in the IL-4R/STAT6 pathway and the Th17 population may serve as parasitic evasion mechanisms in HIV/ML. Further studies are required to confirm these results.
publishDate 2011
dc.date.none.fl_str_mv 2011-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822011000400025
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822011000400025
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0037-86822011000400025
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical - SBMT
publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical - SBMT
dc.source.none.fl_str_mv Revista da Sociedade Brasileira de Medicina Tropical v.44 n.4 2011
reponame:Revista da Sociedade Brasileira de Medicina Tropical
instname:Sociedade Brasileira de Medicina Tropical (SBMT)
instacron:SBMT
instname_str Sociedade Brasileira de Medicina Tropical (SBMT)
instacron_str SBMT
institution SBMT
reponame_str Revista da Sociedade Brasileira de Medicina Tropical
collection Revista da Sociedade Brasileira de Medicina Tropical
repository.name.fl_str_mv Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT)
repository.mail.fl_str_mv ||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br
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