Studies on anti-component 5 antibodies in animals infected with Trypanosoma cruzi

Detalhes bibliográficos
Autor(a) principal: Santoro,F.
Data de Publicação: 1987
Outros Autores: Sadigursky,M., Sherlock,I., Afchain,D., Capron,A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista da Sociedade Brasileira de Medicina Tropical
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821987000200005
Resumo: A competitive antibody enzyme immunoassay, using a monoclonal antibody against the species-specific Trypanosoma crnzi antigen 5, was used to investigate the presence of anti-component 5 antibodies in sera of opossums, dogs, rabbits and rats infected with this parasite. The sera from 51 Venezuelan patients with Chagas’disease were also tested. About 90% of the infected subjects showed significant levels of anti-component 5 antibodies. Nevertheless, these antibodies were not detected in the sera of dogs, rats and opossums infected with T. cruzl Some sera from infected rabbits presented significant results but close to the limit ofpositivity ofthe test. These findings suggest that the immune response in animals naturally or experimentally infected with T. cruzi is different from that observed in human Chagas’disease.
id SBMT-1_ad524008bbf636f61ab258ff75052456
oai_identifier_str oai:scielo:S0037-86821987000200005
network_acronym_str SBMT-1
network_name_str Revista da Sociedade Brasileira de Medicina Tropical
repository_id_str
spelling Studies on anti-component 5 antibodies in animals infected with Trypanosoma cruziTrypanosoma cruziAntibodiesImmunoassayA competitive antibody enzyme immunoassay, using a monoclonal antibody against the species-specific Trypanosoma crnzi antigen 5, was used to investigate the presence of anti-component 5 antibodies in sera of opossums, dogs, rabbits and rats infected with this parasite. The sera from 51 Venezuelan patients with Chagas’disease were also tested. About 90% of the infected subjects showed significant levels of anti-component 5 antibodies. Nevertheless, these antibodies were not detected in the sera of dogs, rats and opossums infected with T. cruzl Some sera from infected rabbits presented significant results but close to the limit ofpositivity ofthe test. These findings suggest that the immune response in animals naturally or experimentally infected with T. cruzi is different from that observed in human Chagas’disease.Sociedade Brasileira de Medicina Tropical - SBMT1987-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821987000200005Revista da Sociedade Brasileira de Medicina Tropical v.20 n.2 1987reponame:Revista da Sociedade Brasileira de Medicina Tropicalinstname:Sociedade Brasileira de Medicina Tropical (SBMT)instacron:SBMT10.1590/S0037-86821987000200005info:eu-repo/semantics/openAccessSantoro,F.Sadigursky,M.Sherlock,I.Afchain,D.Capron,A.eng2013-06-05T00:00:00Zoai:scielo:S0037-86821987000200005Revistahttps://www.sbmt.org.br/portal/revista/ONGhttps://old.scielo.br/oai/scielo-oai.php||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br1678-98490037-8682opendoar:2013-06-05T00:00Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT)false
dc.title.none.fl_str_mv Studies on anti-component 5 antibodies in animals infected with Trypanosoma cruzi
title Studies on anti-component 5 antibodies in animals infected with Trypanosoma cruzi
spellingShingle Studies on anti-component 5 antibodies in animals infected with Trypanosoma cruzi
Santoro,F.
Trypanosoma cruzi
Antibodies
Immunoassay
title_short Studies on anti-component 5 antibodies in animals infected with Trypanosoma cruzi
title_full Studies on anti-component 5 antibodies in animals infected with Trypanosoma cruzi
title_fullStr Studies on anti-component 5 antibodies in animals infected with Trypanosoma cruzi
title_full_unstemmed Studies on anti-component 5 antibodies in animals infected with Trypanosoma cruzi
title_sort Studies on anti-component 5 antibodies in animals infected with Trypanosoma cruzi
author Santoro,F.
author_facet Santoro,F.
Sadigursky,M.
Sherlock,I.
Afchain,D.
Capron,A.
author_role author
author2 Sadigursky,M.
Sherlock,I.
Afchain,D.
Capron,A.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Santoro,F.
Sadigursky,M.
Sherlock,I.
Afchain,D.
Capron,A.
dc.subject.por.fl_str_mv Trypanosoma cruzi
Antibodies
Immunoassay
topic Trypanosoma cruzi
Antibodies
Immunoassay
description A competitive antibody enzyme immunoassay, using a monoclonal antibody against the species-specific Trypanosoma crnzi antigen 5, was used to investigate the presence of anti-component 5 antibodies in sera of opossums, dogs, rabbits and rats infected with this parasite. The sera from 51 Venezuelan patients with Chagas’disease were also tested. About 90% of the infected subjects showed significant levels of anti-component 5 antibodies. Nevertheless, these antibodies were not detected in the sera of dogs, rats and opossums infected with T. cruzl Some sera from infected rabbits presented significant results but close to the limit ofpositivity ofthe test. These findings suggest that the immune response in animals naturally or experimentally infected with T. cruzi is different from that observed in human Chagas’disease.
publishDate 1987
dc.date.none.fl_str_mv 1987-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821987000200005
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821987000200005
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0037-86821987000200005
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical - SBMT
publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical - SBMT
dc.source.none.fl_str_mv Revista da Sociedade Brasileira de Medicina Tropical v.20 n.2 1987
reponame:Revista da Sociedade Brasileira de Medicina Tropical
instname:Sociedade Brasileira de Medicina Tropical (SBMT)
instacron:SBMT
instname_str Sociedade Brasileira de Medicina Tropical (SBMT)
instacron_str SBMT
institution SBMT
reponame_str Revista da Sociedade Brasileira de Medicina Tropical
collection Revista da Sociedade Brasileira de Medicina Tropical
repository.name.fl_str_mv Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT)
repository.mail.fl_str_mv ||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br
_version_ 1752122148618502144

Registros relacionados