Lack of evidence for human infection with Xenotropic murine leukemia virus-related virus in the Brazilian Amazon basin
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista da Sociedade Brasileira de Medicina Tropical |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822014000300302 |
Resumo: | Introduction This study confirmed the absence of natural infection with Xenotropic murine leukemia virus-related virus (XMRV) or XMRV-related disease in human populations of the Brazilian Amazon basin. We demonstrated that 803 individuals of both sexes, who were residents of Belem in the Brazilian State of Pará, were not infected with XMRV. Methods Individuals were divided into 4 subgroups: healthy individuals, individuals infected with human immunodeficiency virus, type 1 (HIV-1), individuals infected with human T-lymphotrophic virus, types 1 or 2 (HTLV-1/2), and individuals with prostate cancer. XMRV infection was investigated by nested PCR to detect the viral gag gene and by quantitative PCR to detect pol. Results There was no amplification of either gag or pol segments from XRMV in any of the samples examined. Conclusions This study supports the conclusions of the studies that eventually led to the retraction of the original study reporting the association between XMRV and human diseases. |
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Lack of evidence for human infection with Xenotropic murine leukemia virus-related virus in the Brazilian Amazon basinXenotropic murine leukemia virus-related virusRetrovirusAmazon regionBrazil Introduction This study confirmed the absence of natural infection with Xenotropic murine leukemia virus-related virus (XMRV) or XMRV-related disease in human populations of the Brazilian Amazon basin. We demonstrated that 803 individuals of both sexes, who were residents of Belem in the Brazilian State of Pará, were not infected with XMRV. Methods Individuals were divided into 4 subgroups: healthy individuals, individuals infected with human immunodeficiency virus, type 1 (HIV-1), individuals infected with human T-lymphotrophic virus, types 1 or 2 (HTLV-1/2), and individuals with prostate cancer. XMRV infection was investigated by nested PCR to detect the viral gag gene and by quantitative PCR to detect pol. Results There was no amplification of either gag or pol segments from XRMV in any of the samples examined. Conclusions This study supports the conclusions of the studies that eventually led to the retraction of the original study reporting the association between XMRV and human diseases. Sociedade Brasileira de Medicina Tropical - SBMT2014-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822014000300302Revista da Sociedade Brasileira de Medicina Tropical v.47 n.3 2014reponame:Revista da Sociedade Brasileira de Medicina Tropicalinstname:Sociedade Brasileira de Medicina Tropical (SBMT)instacron:SBMT10.1590/0037-8682-0075-2014info:eu-repo/semantics/openAccessGomes,Samara Tatielle MonteiroImbiriba,LucianaBurbano,Rommel RodriguézSilva,Artur Luiz da CostaFeitosa,Rosimar Neris MartinsCayres-Vallinoto,Izaura Maria VieiraIshak,Marluísa de Oliveira GuimarãesIshak,RicardoVallinoto,Antonio Carlos Rosárioeng2014-07-23T00:00:00Zoai:scielo:S0037-86822014000300302Revistahttps://www.sbmt.org.br/portal/revista/ONGhttps://old.scielo.br/oai/scielo-oai.php||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br1678-98490037-8682opendoar:2014-07-23T00:00Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT)false |
dc.title.none.fl_str_mv |
Lack of evidence for human infection with Xenotropic murine leukemia virus-related virus in the Brazilian Amazon basin |
title |
Lack of evidence for human infection with Xenotropic murine leukemia virus-related virus in the Brazilian Amazon basin |
spellingShingle |
Lack of evidence for human infection with Xenotropic murine leukemia virus-related virus in the Brazilian Amazon basin Gomes,Samara Tatielle Monteiro Xenotropic murine leukemia virus-related virus Retrovirus Amazon region Brazil |
title_short |
Lack of evidence for human infection with Xenotropic murine leukemia virus-related virus in the Brazilian Amazon basin |
title_full |
Lack of evidence for human infection with Xenotropic murine leukemia virus-related virus in the Brazilian Amazon basin |
title_fullStr |
Lack of evidence for human infection with Xenotropic murine leukemia virus-related virus in the Brazilian Amazon basin |
title_full_unstemmed |
Lack of evidence for human infection with Xenotropic murine leukemia virus-related virus in the Brazilian Amazon basin |
title_sort |
Lack of evidence for human infection with Xenotropic murine leukemia virus-related virus in the Brazilian Amazon basin |
author |
Gomes,Samara Tatielle Monteiro |
author_facet |
Gomes,Samara Tatielle Monteiro Imbiriba,Luciana Burbano,Rommel Rodriguéz Silva,Artur Luiz da Costa Feitosa,Rosimar Neris Martins Cayres-Vallinoto,Izaura Maria Vieira Ishak,Marluísa de Oliveira Guimarães Ishak,Ricardo Vallinoto,Antonio Carlos Rosário |
author_role |
author |
author2 |
Imbiriba,Luciana Burbano,Rommel Rodriguéz Silva,Artur Luiz da Costa Feitosa,Rosimar Neris Martins Cayres-Vallinoto,Izaura Maria Vieira Ishak,Marluísa de Oliveira Guimarães Ishak,Ricardo Vallinoto,Antonio Carlos Rosário |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Gomes,Samara Tatielle Monteiro Imbiriba,Luciana Burbano,Rommel Rodriguéz Silva,Artur Luiz da Costa Feitosa,Rosimar Neris Martins Cayres-Vallinoto,Izaura Maria Vieira Ishak,Marluísa de Oliveira Guimarães Ishak,Ricardo Vallinoto,Antonio Carlos Rosário |
dc.subject.por.fl_str_mv |
Xenotropic murine leukemia virus-related virus Retrovirus Amazon region Brazil |
topic |
Xenotropic murine leukemia virus-related virus Retrovirus Amazon region Brazil |
description |
Introduction This study confirmed the absence of natural infection with Xenotropic murine leukemia virus-related virus (XMRV) or XMRV-related disease in human populations of the Brazilian Amazon basin. We demonstrated that 803 individuals of both sexes, who were residents of Belem in the Brazilian State of Pará, were not infected with XMRV. Methods Individuals were divided into 4 subgroups: healthy individuals, individuals infected with human immunodeficiency virus, type 1 (HIV-1), individuals infected with human T-lymphotrophic virus, types 1 or 2 (HTLV-1/2), and individuals with prostate cancer. XMRV infection was investigated by nested PCR to detect the viral gag gene and by quantitative PCR to detect pol. Results There was no amplification of either gag or pol segments from XRMV in any of the samples examined. Conclusions This study supports the conclusions of the studies that eventually led to the retraction of the original study reporting the association between XMRV and human diseases. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822014000300302 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822014000300302 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0037-8682-0075-2014 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Medicina Tropical - SBMT |
publisher.none.fl_str_mv |
Sociedade Brasileira de Medicina Tropical - SBMT |
dc.source.none.fl_str_mv |
Revista da Sociedade Brasileira de Medicina Tropical v.47 n.3 2014 reponame:Revista da Sociedade Brasileira de Medicina Tropical instname:Sociedade Brasileira de Medicina Tropical (SBMT) instacron:SBMT |
instname_str |
Sociedade Brasileira de Medicina Tropical (SBMT) |
instacron_str |
SBMT |
institution |
SBMT |
reponame_str |
Revista da Sociedade Brasileira de Medicina Tropical |
collection |
Revista da Sociedade Brasileira de Medicina Tropical |
repository.name.fl_str_mv |
Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT) |
repository.mail.fl_str_mv |
||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br |
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