Schistosoma mansoni in mice: modulation of granulomatous response after reinfection and chemotherapeutic treatment
Autor(a) principal: | |
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Data de Publicação: | 1994 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista da Sociedade Brasileira de Medicina Tropical |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821994000300001 |
Resumo: | Mice previously infected with Schistosoma mansoni, and cured by specific treatment (400mg/kg oxamniquine, p. o.) in the chronic phase of the disease, were reinfected 20 days after treatment to assess their capacityfor modulation ofthe granulomatous response. Histopathologic examination of the animals ' liver, at 60 days after reinfection, evidenced the presence of typical granulomas of the chronic phase in most animals. This infer that the capacity for modulation of the granulomatous response had been maintained, thus preventing a new acute phase of the disease. Conversely, a group of previously infected mice, untreated and submitted to reinfection, showed reactivation of the granulomatous response in 50% of the animals. The possible implications of these findings in human schistosomiasis mansoni are discussed. |
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Schistosoma mansoni in mice: modulation of granulomatous response after reinfection and chemotherapeutic treatmentSchistosoma mansoniGranulomaChemotherapeutic treatmentModulation of granulomatous responseMice previously infected with Schistosoma mansoni, and cured by specific treatment (400mg/kg oxamniquine, p. o.) in the chronic phase of the disease, were reinfected 20 days after treatment to assess their capacityfor modulation ofthe granulomatous response. Histopathologic examination of the animals ' liver, at 60 days after reinfection, evidenced the presence of typical granulomas of the chronic phase in most animals. This infer that the capacity for modulation of the granulomatous response had been maintained, thus preventing a new acute phase of the disease. Conversely, a group of previously infected mice, untreated and submitted to reinfection, showed reactivation of the granulomatous response in 50% of the animals. The possible implications of these findings in human schistosomiasis mansoni are discussed.Sociedade Brasileira de Medicina Tropical - SBMT1994-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821994000300001Revista da Sociedade Brasileira de Medicina Tropical v.27 n.3 1994reponame:Revista da Sociedade Brasileira de Medicina Tropicalinstname:Sociedade Brasileira de Medicina Tropical (SBMT)instacron:SBMT10.1590/S0037-86821994000300001info:eu-repo/semantics/openAccessCoelho,Paulo Marcos Z.Raso,PedroMello,Rômulo Teixeira deToppa,Nivaldo H.eng2013-04-12T00:00:00Zoai:scielo:S0037-86821994000300001Revistahttps://www.sbmt.org.br/portal/revista/ONGhttps://old.scielo.br/oai/scielo-oai.php||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br1678-98490037-8682opendoar:2013-04-12T00:00Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT)false |
dc.title.none.fl_str_mv |
Schistosoma mansoni in mice: modulation of granulomatous response after reinfection and chemotherapeutic treatment |
title |
Schistosoma mansoni in mice: modulation of granulomatous response after reinfection and chemotherapeutic treatment |
spellingShingle |
Schistosoma mansoni in mice: modulation of granulomatous response after reinfection and chemotherapeutic treatment Coelho,Paulo Marcos Z. Schistosoma mansoni Granuloma Chemotherapeutic treatment Modulation of granulomatous response |
title_short |
Schistosoma mansoni in mice: modulation of granulomatous response after reinfection and chemotherapeutic treatment |
title_full |
Schistosoma mansoni in mice: modulation of granulomatous response after reinfection and chemotherapeutic treatment |
title_fullStr |
Schistosoma mansoni in mice: modulation of granulomatous response after reinfection and chemotherapeutic treatment |
title_full_unstemmed |
Schistosoma mansoni in mice: modulation of granulomatous response after reinfection and chemotherapeutic treatment |
title_sort |
Schistosoma mansoni in mice: modulation of granulomatous response after reinfection and chemotherapeutic treatment |
author |
Coelho,Paulo Marcos Z. |
author_facet |
Coelho,Paulo Marcos Z. Raso,Pedro Mello,Rômulo Teixeira de Toppa,Nivaldo H. |
author_role |
author |
author2 |
Raso,Pedro Mello,Rômulo Teixeira de Toppa,Nivaldo H. |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Coelho,Paulo Marcos Z. Raso,Pedro Mello,Rômulo Teixeira de Toppa,Nivaldo H. |
dc.subject.por.fl_str_mv |
Schistosoma mansoni Granuloma Chemotherapeutic treatment Modulation of granulomatous response |
topic |
Schistosoma mansoni Granuloma Chemotherapeutic treatment Modulation of granulomatous response |
description |
Mice previously infected with Schistosoma mansoni, and cured by specific treatment (400mg/kg oxamniquine, p. o.) in the chronic phase of the disease, were reinfected 20 days after treatment to assess their capacityfor modulation ofthe granulomatous response. Histopathologic examination of the animals ' liver, at 60 days after reinfection, evidenced the presence of typical granulomas of the chronic phase in most animals. This infer that the capacity for modulation of the granulomatous response had been maintained, thus preventing a new acute phase of the disease. Conversely, a group of previously infected mice, untreated and submitted to reinfection, showed reactivation of the granulomatous response in 50% of the animals. The possible implications of these findings in human schistosomiasis mansoni are discussed. |
publishDate |
1994 |
dc.date.none.fl_str_mv |
1994-09-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821994000300001 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821994000300001 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0037-86821994000300001 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Medicina Tropical - SBMT |
publisher.none.fl_str_mv |
Sociedade Brasileira de Medicina Tropical - SBMT |
dc.source.none.fl_str_mv |
Revista da Sociedade Brasileira de Medicina Tropical v.27 n.3 1994 reponame:Revista da Sociedade Brasileira de Medicina Tropical instname:Sociedade Brasileira de Medicina Tropical (SBMT) instacron:SBMT |
instname_str |
Sociedade Brasileira de Medicina Tropical (SBMT) |
instacron_str |
SBMT |
institution |
SBMT |
reponame_str |
Revista da Sociedade Brasileira de Medicina Tropical |
collection |
Revista da Sociedade Brasileira de Medicina Tropical |
repository.name.fl_str_mv |
Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT) |
repository.mail.fl_str_mv |
||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br |
_version_ |
1752122149488820224 |