ACQUIRED MYASTHENIA GRAVIS IN DOG – CASE REPORT

Detalhes bibliográficos
Autor(a) principal: dos Santos Lopes Fernandes, Maria Eduarda
Data de Publicação: 2021
Outros Autores: Wacheleski Brock, Gabriela, Rodrigues Peixoto, Anna Julia, Gonring Corrêa, Clarice, de Oliveira, Patricia, Gradowski Adeodato, Alex, Albuquerque da Silva, Marta Fernanda, Molinaro Coelho, Cássia Maria
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Veterinary Medicine
Texto Completo: https://rbmv.org/BJVM/article/view/1063
Resumo: Neuromuscular diseases are uncommon in the clinical routine of dogs and cats and their diagnosis is a challenge for the veterinarian. Thus, this paper reports the clinical diagnosis and established therapy in a four-year-old female without a defined breed with a history of ataxia and tetraparesis, especially after exercise. Due to the history and clinical signs presented, acquired myasthenia gravis was suspected and the therapeutic diagnosis was chosen using anticholinesterase neostigmine, for being simpler, faster and more accessible. The patient presented a significant improvement in clinical status after administration of neostigmine intramuscularly, returning to normal ambulatory activity after administration of the drug intravenously, thus making possible the diagnosis of the disease. Treatment was instituted using pyridostigmine bromide associated with corticosteroid in a immunosuppressive dose for a period of six months, observing complete remission of the clinical signs without recurrences until the present moment.
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spelling ACQUIRED MYASTHENIA GRAVIS IN DOG – CASE REPORTMiastenia gravis adquirida em cão – relato de casomegaesôfago, desordem neuromuscular, neostigmina, neurologia veterinária.megaesophagus, neuromuscular disorder, neostigmine, veterinary neurology.Neuromuscular diseases are uncommon in the clinical routine of dogs and cats and their diagnosis is a challenge for the veterinarian. Thus, this paper reports the clinical diagnosis and established therapy in a four-year-old female without a defined breed with a history of ataxia and tetraparesis, especially after exercise. Due to the history and clinical signs presented, acquired myasthenia gravis was suspected and the therapeutic diagnosis was chosen using anticholinesterase neostigmine, for being simpler, faster and more accessible. The patient presented a significant improvement in clinical status after administration of neostigmine intramuscularly, returning to normal ambulatory activity after administration of the drug intravenously, thus making possible the diagnosis of the disease. Treatment was instituted using pyridostigmine bromide associated with corticosteroid in a immunosuppressive dose for a period of six months, observing complete remission of the clinical signs without recurrences until the present moment.Doenças neuromusculares são incomuns na rotina clínica de cães e gatos e o seu diagnóstico é um desafio para o Médico Veterinário. Desta forma, este trabalho relata o diagnóstico clínico e terapêutico em uma cadela sem raça definida de quatro anos com histórico de claudicação e paresia intermitente, inicialmente em membros pélvicos evoluindo para membros torácicos, apresentando sinais clínicos de ataxia e tetraparesia sobretudo após exercício. Em virtude do histórico e sinais clínicos apresentados suspeitou-se de miastenia gravis adquirida, optando-se pelo diagnóstico terapêutico, por ser mais simples, rápido e acessível, utilizando o anticolinesterásico neostigmina. A paciente apresentou melhora significativa no quadro clínico após administração do referido anticolinesterásico por via intramuscular, retornando à atividade deambulatória normal após administração do fármaco por via intravenosa, sendo possível assim o diagnóstico da doença. Foi instituído tratamento utilizando o brometo de piridostigmina (2,5mg/Kg, duas vezes ao dia) associado ao corticosteroide em dose imunossupressora (0,5mg/Kg, duas vezes ao dia), ambos por via oral, por um período de seis meses, observando-se remissão completa dos sinais clínicos sem recidivas até o presente momento.Sociedade de Medicina Veterinária do Estado do Rio de Janeiro.2021-05-13info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rbmv.org/BJVM/article/view/106310.29374/2527-2179.bjvm106320Brazilian Journal of Veterinary Medicine; Vol. 42 No. 1 (2020); e106320Revista Brasileira de Medicina Veterinária; v. 42 n. 1 (2020); e1063202527-21790100-2430reponame:Brazilian Journal of Veterinary Medicineinstname:Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ)instacron:SBMVenghttps://rbmv.org/BJVM/article/view/1063/987Copyright (c) 2020 Maria Eduarda dos Santos Lopes Fernandes, Gabriela Wacheleski Brock, Anna Julia Rodrigues Peixoto, Clarice Gonring Corrêa, Patricia de Oliveira, Alex Gradowski Adeodato, Marta Fernanda Albuquerque da Silva, Cássia Maria Molinaro Coelhohttp://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessdos Santos Lopes Fernandes, Maria EduardaWacheleski Brock, GabrielaRodrigues Peixoto, Anna JuliaGonring Corrêa, Claricede Oliveira, PatriciaGradowski Adeodato, AlexAlbuquerque da Silva, Marta FernandaMolinaro Coelho, Cássia Maria2021-05-13T13:46:40Zoai:ojs.rbmv.org:article/1063Revistahttps://rbmv.org/BJVMONGhttps://rbmv.org/BJVM/oaicontato.rbmv@gmail.com2527-21790100-2430opendoar:2021-05-13T13:46:40Brazilian Journal of Veterinary Medicine - Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ)false
dc.title.none.fl_str_mv ACQUIRED MYASTHENIA GRAVIS IN DOG – CASE REPORT
Miastenia gravis adquirida em cão – relato de caso
title ACQUIRED MYASTHENIA GRAVIS IN DOG – CASE REPORT
spellingShingle ACQUIRED MYASTHENIA GRAVIS IN DOG – CASE REPORT
dos Santos Lopes Fernandes, Maria Eduarda
megaesôfago, desordem neuromuscular, neostigmina, neurologia veterinária.
megaesophagus, neuromuscular disorder, neostigmine, veterinary neurology.
title_short ACQUIRED MYASTHENIA GRAVIS IN DOG – CASE REPORT
title_full ACQUIRED MYASTHENIA GRAVIS IN DOG – CASE REPORT
title_fullStr ACQUIRED MYASTHENIA GRAVIS IN DOG – CASE REPORT
title_full_unstemmed ACQUIRED MYASTHENIA GRAVIS IN DOG – CASE REPORT
title_sort ACQUIRED MYASTHENIA GRAVIS IN DOG – CASE REPORT
author dos Santos Lopes Fernandes, Maria Eduarda
author_facet dos Santos Lopes Fernandes, Maria Eduarda
Wacheleski Brock, Gabriela
Rodrigues Peixoto, Anna Julia
Gonring Corrêa, Clarice
de Oliveira, Patricia
Gradowski Adeodato, Alex
Albuquerque da Silva, Marta Fernanda
Molinaro Coelho, Cássia Maria
author_role author
author2 Wacheleski Brock, Gabriela
Rodrigues Peixoto, Anna Julia
Gonring Corrêa, Clarice
de Oliveira, Patricia
Gradowski Adeodato, Alex
Albuquerque da Silva, Marta Fernanda
Molinaro Coelho, Cássia Maria
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv dos Santos Lopes Fernandes, Maria Eduarda
Wacheleski Brock, Gabriela
Rodrigues Peixoto, Anna Julia
Gonring Corrêa, Clarice
de Oliveira, Patricia
Gradowski Adeodato, Alex
Albuquerque da Silva, Marta Fernanda
Molinaro Coelho, Cássia Maria
dc.subject.por.fl_str_mv megaesôfago, desordem neuromuscular, neostigmina, neurologia veterinária.
megaesophagus, neuromuscular disorder, neostigmine, veterinary neurology.
topic megaesôfago, desordem neuromuscular, neostigmina, neurologia veterinária.
megaesophagus, neuromuscular disorder, neostigmine, veterinary neurology.
description Neuromuscular diseases are uncommon in the clinical routine of dogs and cats and their diagnosis is a challenge for the veterinarian. Thus, this paper reports the clinical diagnosis and established therapy in a four-year-old female without a defined breed with a history of ataxia and tetraparesis, especially after exercise. Due to the history and clinical signs presented, acquired myasthenia gravis was suspected and the therapeutic diagnosis was chosen using anticholinesterase neostigmine, for being simpler, faster and more accessible. The patient presented a significant improvement in clinical status after administration of neostigmine intramuscularly, returning to normal ambulatory activity after administration of the drug intravenously, thus making possible the diagnosis of the disease. Treatment was instituted using pyridostigmine bromide associated with corticosteroid in a immunosuppressive dose for a period of six months, observing complete remission of the clinical signs without recurrences until the present moment.
publishDate 2021
dc.date.none.fl_str_mv 2021-05-13
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rbmv.org/BJVM/article/view/1063
10.29374/2527-2179.bjvm106320
url https://rbmv.org/BJVM/article/view/1063
identifier_str_mv 10.29374/2527-2179.bjvm106320
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://rbmv.org/BJVM/article/view/1063/987
dc.rights.driver.fl_str_mv http://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Sociedade de Medicina Veterinária do Estado do Rio de Janeiro.
publisher.none.fl_str_mv Sociedade de Medicina Veterinária do Estado do Rio de Janeiro.
dc.source.none.fl_str_mv Brazilian Journal of Veterinary Medicine; Vol. 42 No. 1 (2020); e106320
Revista Brasileira de Medicina Veterinária; v. 42 n. 1 (2020); e106320
2527-2179
0100-2430
reponame:Brazilian Journal of Veterinary Medicine
instname:Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ)
instacron:SBMV
instname_str Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ)
instacron_str SBMV
institution SBMV
reponame_str Brazilian Journal of Veterinary Medicine
collection Brazilian Journal of Veterinary Medicine
repository.name.fl_str_mv Brazilian Journal of Veterinary Medicine - Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ)
repository.mail.fl_str_mv contato.rbmv@gmail.com
_version_ 1798313110625320960

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