The long-term use of enalapril and hydrochlorothiazide in two novel mutations patients with Dent's disease type 1

Detalhes bibliográficos
Autor(a) principal: Vaisbich,Maria Helena
Data de Publicação: 2012
Outros Autores: Henriques,Luciana dos Santos, Igarashi,Takashi, Sekine,Takashi, Seki,George, Koch,Vera H
Tipo de documento: Relatório
Idioma: eng
Título da fonte: Jornal Brasileiro de Nefrologia
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002012000100013
Resumo: Dent's disease type 1 is an X-linked tubular disease caused by mutations in the renal chloride channel CLCN-5, and it is characterized by low molecular weight proteinuria, hypercalciuria, nephrocalcinosis, and renal failure. Several cases have been described in which the only presenting symptoms were asymptomatic proteinuria, and focal segmental or global glomerulosclerosis. The renal failure in these patients may be caused by hypercalciuria and persistent proteinuria. Therefore, angiotensin converse enzyme inhibitor and thiazides could be useful. Our aim is to report the effects of these drugs in two novel mutations patients with Dent's disease type 1. In this report, no significant correlations between dosage of hydrochlorothiazide and calciuria and no significant correlations between proteinuria and dosage of enalapril were detected. This is important since these are polyuric patients and these drugs could be dangerous to their renal function.
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spelling The long-term use of enalapril and hydrochlorothiazide in two novel mutations patients with Dent's disease type 1EnalaprilProteinuriaHypercalciuriaHydrochlorothiazideDent DiseaseDent's disease type 1 is an X-linked tubular disease caused by mutations in the renal chloride channel CLCN-5, and it is characterized by low molecular weight proteinuria, hypercalciuria, nephrocalcinosis, and renal failure. Several cases have been described in which the only presenting symptoms were asymptomatic proteinuria, and focal segmental or global glomerulosclerosis. The renal failure in these patients may be caused by hypercalciuria and persistent proteinuria. Therefore, angiotensin converse enzyme inhibitor and thiazides could be useful. Our aim is to report the effects of these drugs in two novel mutations patients with Dent's disease type 1. In this report, no significant correlations between dosage of hydrochlorothiazide and calciuria and no significant correlations between proteinuria and dosage of enalapril were detected. This is important since these are polyuric patients and these drugs could be dangerous to their renal function.Sociedade Brasileira de Nefrologia2012-03-01info:eu-repo/semantics/reportinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002012000100013Brazilian Journal of Nephrology v.34 n.1 2012reponame:Jornal Brasileiro de Nefrologiainstname:Sociedade Brasileira de Nefrologia (SBN)instacron:SBN10.1590/S0101-28002012000100013info:eu-repo/semantics/openAccessVaisbich,Maria HelenaHenriques,Luciana dos SantosIgarashi,TakashiSekine,TakashiSeki,GeorgeKoch,Vera Heng2012-03-20T00:00:00Zoai:scielo:S0101-28002012000100013Revistahttp://www.bjn.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||jbn@sbn.org.br2175-82390101-2800opendoar:2012-03-20T00:00Jornal Brasileiro de Nefrologia - Sociedade Brasileira de Nefrologia (SBN)false
dc.title.none.fl_str_mv The long-term use of enalapril and hydrochlorothiazide in two novel mutations patients with Dent's disease type 1
title The long-term use of enalapril and hydrochlorothiazide in two novel mutations patients with Dent's disease type 1
spellingShingle The long-term use of enalapril and hydrochlorothiazide in two novel mutations patients with Dent's disease type 1
Vaisbich,Maria Helena
Enalapril
Proteinuria
Hypercalciuria
Hydrochlorothiazide
Dent Disease
title_short The long-term use of enalapril and hydrochlorothiazide in two novel mutations patients with Dent's disease type 1
title_full The long-term use of enalapril and hydrochlorothiazide in two novel mutations patients with Dent's disease type 1
title_fullStr The long-term use of enalapril and hydrochlorothiazide in two novel mutations patients with Dent's disease type 1
title_full_unstemmed The long-term use of enalapril and hydrochlorothiazide in two novel mutations patients with Dent's disease type 1
title_sort The long-term use of enalapril and hydrochlorothiazide in two novel mutations patients with Dent's disease type 1
author Vaisbich,Maria Helena
author_facet Vaisbich,Maria Helena
Henriques,Luciana dos Santos
Igarashi,Takashi
Sekine,Takashi
Seki,George
Koch,Vera H
author_role author
author2 Henriques,Luciana dos Santos
Igarashi,Takashi
Sekine,Takashi
Seki,George
Koch,Vera H
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Vaisbich,Maria Helena
Henriques,Luciana dos Santos
Igarashi,Takashi
Sekine,Takashi
Seki,George
Koch,Vera H
dc.subject.por.fl_str_mv Enalapril
Proteinuria
Hypercalciuria
Hydrochlorothiazide
Dent Disease
topic Enalapril
Proteinuria
Hypercalciuria
Hydrochlorothiazide
Dent Disease
description Dent's disease type 1 is an X-linked tubular disease caused by mutations in the renal chloride channel CLCN-5, and it is characterized by low molecular weight proteinuria, hypercalciuria, nephrocalcinosis, and renal failure. Several cases have been described in which the only presenting symptoms were asymptomatic proteinuria, and focal segmental or global glomerulosclerosis. The renal failure in these patients may be caused by hypercalciuria and persistent proteinuria. Therefore, angiotensin converse enzyme inhibitor and thiazides could be useful. Our aim is to report the effects of these drugs in two novel mutations patients with Dent's disease type 1. In this report, no significant correlations between dosage of hydrochlorothiazide and calciuria and no significant correlations between proteinuria and dosage of enalapril were detected. This is important since these are polyuric patients and these drugs could be dangerous to their renal function.
publishDate 2012
dc.date.none.fl_str_mv 2012-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/report
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002012000100013
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002012000100013
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0101-28002012000100013
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Nefrologia
publisher.none.fl_str_mv Sociedade Brasileira de Nefrologia
dc.source.none.fl_str_mv Brazilian Journal of Nephrology v.34 n.1 2012
reponame:Jornal Brasileiro de Nefrologia
instname:Sociedade Brasileira de Nefrologia (SBN)
instacron:SBN
instname_str Sociedade Brasileira de Nefrologia (SBN)
instacron_str SBN
institution SBN
reponame_str Jornal Brasileiro de Nefrologia
collection Jornal Brasileiro de Nefrologia
repository.name.fl_str_mv Jornal Brasileiro de Nefrologia - Sociedade Brasileira de Nefrologia (SBN)
repository.mail.fl_str_mv ||jbn@sbn.org.br
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