Vitamin D and Kidney disease: what we know and what we do not know

Detalhes bibliográficos
Autor(a) principal: Inda Filho,Antonio Jose
Data de Publicação: 2013
Outros Autores: Melamed,Michal Leora
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Jornal Brasileiro de Nefrologia
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002013000400012
Resumo: Vitamin D deficiency is common in the chronic kidney disease (CKD) population. CKD has been recognized as a significant public health problem and CKD patients are at increased risk of total and cardiovascular morbidity and mortality. There are increasing epidemiological data suggesting that vitamin D deficiency may play a role in overall morbidity and mortality associated with CKD. The vitamin D hormonal system is classically implicated in the regulation of calcium homeostasis and bone metabolism but there is ample evidence to support the claim that extra renal conversion of 25(OH)D to 1.25(OH)2 has significant biological roles beyond those traditionally ascribed to vitamin D. Based on the current state of evidence this review intends to give an update on novel biological and clinical insights with relevance to the steroid hormone vitamin D specifically in patients with kidney disease.
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spelling Vitamin D and Kidney disease: what we know and what we do not know25-hydroxyvitamin D2kidney failurechronicvitamin D deficiencyVitamin D deficiency is common in the chronic kidney disease (CKD) population. CKD has been recognized as a significant public health problem and CKD patients are at increased risk of total and cardiovascular morbidity and mortality. There are increasing epidemiological data suggesting that vitamin D deficiency may play a role in overall morbidity and mortality associated with CKD. The vitamin D hormonal system is classically implicated in the regulation of calcium homeostasis and bone metabolism but there is ample evidence to support the claim that extra renal conversion of 25(OH)D to 1.25(OH)2 has significant biological roles beyond those traditionally ascribed to vitamin D. Based on the current state of evidence this review intends to give an update on novel biological and clinical insights with relevance to the steroid hormone vitamin D specifically in patients with kidney disease.Sociedade Brasileira de Nefrologia2013-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002013000400012Brazilian Journal of Nephrology v.35 n.4 2013reponame:Jornal Brasileiro de Nefrologiainstname:Sociedade Brasileira de Nefrologia (SBN)instacron:SBN10.5935/0101-2800.20130051info:eu-repo/semantics/openAccessInda Filho,Antonio JoseMelamed,Michal Leoraeng2013-12-19T00:00:00Zoai:scielo:S0101-28002013000400012Revistahttp://www.bjn.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||jbn@sbn.org.br2175-82390101-2800opendoar:2013-12-19T00:00Jornal Brasileiro de Nefrologia - Sociedade Brasileira de Nefrologia (SBN)false
dc.title.none.fl_str_mv Vitamin D and Kidney disease: what we know and what we do not know
title Vitamin D and Kidney disease: what we know and what we do not know
spellingShingle Vitamin D and Kidney disease: what we know and what we do not know
Inda Filho,Antonio Jose
25-hydroxyvitamin D2
kidney failure
chronic
vitamin D deficiency
title_short Vitamin D and Kidney disease: what we know and what we do not know
title_full Vitamin D and Kidney disease: what we know and what we do not know
title_fullStr Vitamin D and Kidney disease: what we know and what we do not know
title_full_unstemmed Vitamin D and Kidney disease: what we know and what we do not know
title_sort Vitamin D and Kidney disease: what we know and what we do not know
author Inda Filho,Antonio Jose
author_facet Inda Filho,Antonio Jose
Melamed,Michal Leora
author_role author
author2 Melamed,Michal Leora
author2_role author
dc.contributor.author.fl_str_mv Inda Filho,Antonio Jose
Melamed,Michal Leora
dc.subject.por.fl_str_mv 25-hydroxyvitamin D2
kidney failure
chronic
vitamin D deficiency
topic 25-hydroxyvitamin D2
kidney failure
chronic
vitamin D deficiency
description Vitamin D deficiency is common in the chronic kidney disease (CKD) population. CKD has been recognized as a significant public health problem and CKD patients are at increased risk of total and cardiovascular morbidity and mortality. There are increasing epidemiological data suggesting that vitamin D deficiency may play a role in overall morbidity and mortality associated with CKD. The vitamin D hormonal system is classically implicated in the regulation of calcium homeostasis and bone metabolism but there is ample evidence to support the claim that extra renal conversion of 25(OH)D to 1.25(OH)2 has significant biological roles beyond those traditionally ascribed to vitamin D. Based on the current state of evidence this review intends to give an update on novel biological and clinical insights with relevance to the steroid hormone vitamin D specifically in patients with kidney disease.
publishDate 2013
dc.date.none.fl_str_mv 2013-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002013000400012
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002013000400012
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/0101-2800.20130051
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Nefrologia
publisher.none.fl_str_mv Sociedade Brasileira de Nefrologia
dc.source.none.fl_str_mv Brazilian Journal of Nephrology v.35 n.4 2013
reponame:Jornal Brasileiro de Nefrologia
instname:Sociedade Brasileira de Nefrologia (SBN)
instacron:SBN
instname_str Sociedade Brasileira de Nefrologia (SBN)
instacron_str SBN
institution SBN
reponame_str Jornal Brasileiro de Nefrologia
collection Jornal Brasileiro de Nefrologia
repository.name.fl_str_mv Jornal Brasileiro de Nefrologia - Sociedade Brasileira de Nefrologia (SBN)
repository.mail.fl_str_mv ||jbn@sbn.org.br
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