EFFECT OF HYPERBARIC OXYGEN THERAPY ON NERVE REGENERATION IN RATS
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Acta Ortopédica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-78522022000200200 |
Resumo: | ABSTRACT Objective: To evaluate histological changes in peripheral nerves of rats after sciatic nerve neurorrhaphy, according to the time of exposure to hyperbaric oxygen chamber treatment. Methods: Twenty-five Wistar rats were divided into 5 groups according to the amount of exposure to hyperbaric oxygen chamber treatment. Group 1 was the control and there was no use of hyperbaric oxygen chamber; group 2 received one week of therapy; group 3, two weeks; group 4, three weeks; and group 5, four weeks. After the fourth postoperative week, the animals were submitted to euthanasia and a sciatic nerve sample sent for histological analysis. Axons proximal and distal to the neurorrhaphy were counted with axonal regeneration index measurement. Results: We observed that the number of axons distal to neurorrhaphy increases with the amount of hyperbaric oxygen chamber exposure, the results were more expressive from the third week of treatment. However, the statistical analysis found no significant difference between the groups. Conclusion: The descriptive analysis suggests benefit of using hyperbaric oxygen chamber directly proportional to the time of therapy. The study, however, did not present statistically relevant results, probably due to the reduced sample size. Subsequent studies with more significant sampling would be of great value. Level of Evidence II, Prospective Comparative Study. |
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Acta Ortopédica Brasileira (Online) |
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EFFECT OF HYPERBARIC OXYGEN THERAPY ON NERVE REGENERATION IN RATSPeripheral NervesHyperbaric OxygenationNerve RegenerationRatsABSTRACT Objective: To evaluate histological changes in peripheral nerves of rats after sciatic nerve neurorrhaphy, according to the time of exposure to hyperbaric oxygen chamber treatment. Methods: Twenty-five Wistar rats were divided into 5 groups according to the amount of exposure to hyperbaric oxygen chamber treatment. Group 1 was the control and there was no use of hyperbaric oxygen chamber; group 2 received one week of therapy; group 3, two weeks; group 4, three weeks; and group 5, four weeks. After the fourth postoperative week, the animals were submitted to euthanasia and a sciatic nerve sample sent for histological analysis. Axons proximal and distal to the neurorrhaphy were counted with axonal regeneration index measurement. Results: We observed that the number of axons distal to neurorrhaphy increases with the amount of hyperbaric oxygen chamber exposure, the results were more expressive from the third week of treatment. However, the statistical analysis found no significant difference between the groups. Conclusion: The descriptive analysis suggests benefit of using hyperbaric oxygen chamber directly proportional to the time of therapy. The study, however, did not present statistically relevant results, probably due to the reduced sample size. Subsequent studies with more significant sampling would be of great value. Level of Evidence II, Prospective Comparative Study.ATHA EDITORA2022-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-78522022000200200Acta Ortopédica Brasileira v.30 n.2 2022reponame:Acta Ortopédica Brasileira (Online)instname:Sociedade Brasileira de Ortopedia e Traumatologia (SBOT)instacron:SBOT10.1590/1413-785220223002191015info:eu-repo/semantics/openAccessBARROS,THIAGO FELIPE DOS SANTOSPAULOS,RENATA GREGORIOIWASE,FERNANDA DO CARMOSANTOS,GUSTAVO BISPO DOSREZENDE,MARCELO ROSA DEMATTAR JÚNIOR,RAMESeng2022-06-03T00:00:00Zoai:scielo:S1413-78522022000200200Revistahttp://www.actaortopedica.com.br/https://old.scielo.br/oai/scielo-oai.php1atha@uol.com.br||actaortopedicabrasileira@uol.com.br1809-44061413-7852opendoar:2022-06-03T00:00Acta Ortopédica Brasileira (Online) - Sociedade Brasileira de Ortopedia e Traumatologia (SBOT)false |
dc.title.none.fl_str_mv |
EFFECT OF HYPERBARIC OXYGEN THERAPY ON NERVE REGENERATION IN RATS |
title |
EFFECT OF HYPERBARIC OXYGEN THERAPY ON NERVE REGENERATION IN RATS |
spellingShingle |
EFFECT OF HYPERBARIC OXYGEN THERAPY ON NERVE REGENERATION IN RATS BARROS,THIAGO FELIPE DOS SANTOS Peripheral Nerves Hyperbaric Oxygenation Nerve Regeneration Rats |
title_short |
EFFECT OF HYPERBARIC OXYGEN THERAPY ON NERVE REGENERATION IN RATS |
title_full |
EFFECT OF HYPERBARIC OXYGEN THERAPY ON NERVE REGENERATION IN RATS |
title_fullStr |
EFFECT OF HYPERBARIC OXYGEN THERAPY ON NERVE REGENERATION IN RATS |
title_full_unstemmed |
EFFECT OF HYPERBARIC OXYGEN THERAPY ON NERVE REGENERATION IN RATS |
title_sort |
EFFECT OF HYPERBARIC OXYGEN THERAPY ON NERVE REGENERATION IN RATS |
author |
BARROS,THIAGO FELIPE DOS SANTOS |
author_facet |
BARROS,THIAGO FELIPE DOS SANTOS PAULOS,RENATA GREGORIO IWASE,FERNANDA DO CARMO SANTOS,GUSTAVO BISPO DOS REZENDE,MARCELO ROSA DE MATTAR JÚNIOR,RAMES |
author_role |
author |
author2 |
PAULOS,RENATA GREGORIO IWASE,FERNANDA DO CARMO SANTOS,GUSTAVO BISPO DOS REZENDE,MARCELO ROSA DE MATTAR JÚNIOR,RAMES |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
BARROS,THIAGO FELIPE DOS SANTOS PAULOS,RENATA GREGORIO IWASE,FERNANDA DO CARMO SANTOS,GUSTAVO BISPO DOS REZENDE,MARCELO ROSA DE MATTAR JÚNIOR,RAMES |
dc.subject.por.fl_str_mv |
Peripheral Nerves Hyperbaric Oxygenation Nerve Regeneration Rats |
topic |
Peripheral Nerves Hyperbaric Oxygenation Nerve Regeneration Rats |
description |
ABSTRACT Objective: To evaluate histological changes in peripheral nerves of rats after sciatic nerve neurorrhaphy, according to the time of exposure to hyperbaric oxygen chamber treatment. Methods: Twenty-five Wistar rats were divided into 5 groups according to the amount of exposure to hyperbaric oxygen chamber treatment. Group 1 was the control and there was no use of hyperbaric oxygen chamber; group 2 received one week of therapy; group 3, two weeks; group 4, three weeks; and group 5, four weeks. After the fourth postoperative week, the animals were submitted to euthanasia and a sciatic nerve sample sent for histological analysis. Axons proximal and distal to the neurorrhaphy were counted with axonal regeneration index measurement. Results: We observed that the number of axons distal to neurorrhaphy increases with the amount of hyperbaric oxygen chamber exposure, the results were more expressive from the third week of treatment. However, the statistical analysis found no significant difference between the groups. Conclusion: The descriptive analysis suggests benefit of using hyperbaric oxygen chamber directly proportional to the time of therapy. The study, however, did not present statistically relevant results, probably due to the reduced sample size. Subsequent studies with more significant sampling would be of great value. Level of Evidence II, Prospective Comparative Study. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-78522022000200200 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-78522022000200200 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1413-785220223002191015 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
ATHA EDITORA |
publisher.none.fl_str_mv |
ATHA EDITORA |
dc.source.none.fl_str_mv |
Acta Ortopédica Brasileira v.30 n.2 2022 reponame:Acta Ortopédica Brasileira (Online) instname:Sociedade Brasileira de Ortopedia e Traumatologia (SBOT) instacron:SBOT |
instname_str |
Sociedade Brasileira de Ortopedia e Traumatologia (SBOT) |
instacron_str |
SBOT |
institution |
SBOT |
reponame_str |
Acta Ortopédica Brasileira (Online) |
collection |
Acta Ortopédica Brasileira (Online) |
repository.name.fl_str_mv |
Acta Ortopédica Brasileira (Online) - Sociedade Brasileira de Ortopedia e Traumatologia (SBOT) |
repository.mail.fl_str_mv |
1atha@uol.com.br||actaortopedicabrasileira@uol.com.br |
_version_ |
1752122276995661824 |