EFFECT OF HYPERBARIC OXYGEN THERAPY ON NERVE REGENERATION IN RATS

Detalhes bibliográficos
Autor(a) principal: BARROS,THIAGO FELIPE DOS SANTOS
Data de Publicação: 2022
Outros Autores: PAULOS,RENATA GREGORIO, IWASE,FERNANDA DO CARMO, SANTOS,GUSTAVO BISPO DOS, REZENDE,MARCELO ROSA DE, MATTAR JÚNIOR,RAMES
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Ortopédica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-78522022000200200
Resumo: ABSTRACT Objective: To evaluate histological changes in peripheral nerves of rats after sciatic nerve neurorrhaphy, according to the time of exposure to hyperbaric oxygen chamber treatment. Methods: Twenty-five Wistar rats were divided into 5 groups according to the amount of exposure to hyperbaric oxygen chamber treatment. Group 1 was the control and there was no use of hyperbaric oxygen chamber; group 2 received one week of therapy; group 3, two weeks; group 4, three weeks; and group 5, four weeks. After the fourth postoperative week, the animals were submitted to euthanasia and a sciatic nerve sample sent for histological analysis. Axons proximal and distal to the neurorrhaphy were counted with axonal regeneration index measurement. Results: We observed that the number of axons distal to neurorrhaphy increases with the amount of hyperbaric oxygen chamber exposure, the results were more expressive from the third week of treatment. However, the statistical analysis found no significant difference between the groups. Conclusion: The descriptive analysis suggests benefit of using hyperbaric oxygen chamber directly proportional to the time of therapy. The study, however, did not present statistically relevant results, probably due to the reduced sample size. Subsequent studies with more significant sampling would be of great value. Level of Evidence II, Prospective Comparative Study.
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spelling EFFECT OF HYPERBARIC OXYGEN THERAPY ON NERVE REGENERATION IN RATSPeripheral NervesHyperbaric OxygenationNerve RegenerationRatsABSTRACT Objective: To evaluate histological changes in peripheral nerves of rats after sciatic nerve neurorrhaphy, according to the time of exposure to hyperbaric oxygen chamber treatment. Methods: Twenty-five Wistar rats were divided into 5 groups according to the amount of exposure to hyperbaric oxygen chamber treatment. Group 1 was the control and there was no use of hyperbaric oxygen chamber; group 2 received one week of therapy; group 3, two weeks; group 4, three weeks; and group 5, four weeks. After the fourth postoperative week, the animals were submitted to euthanasia and a sciatic nerve sample sent for histological analysis. Axons proximal and distal to the neurorrhaphy were counted with axonal regeneration index measurement. Results: We observed that the number of axons distal to neurorrhaphy increases with the amount of hyperbaric oxygen chamber exposure, the results were more expressive from the third week of treatment. However, the statistical analysis found no significant difference between the groups. Conclusion: The descriptive analysis suggests benefit of using hyperbaric oxygen chamber directly proportional to the time of therapy. The study, however, did not present statistically relevant results, probably due to the reduced sample size. Subsequent studies with more significant sampling would be of great value. Level of Evidence II, Prospective Comparative Study.ATHA EDITORA2022-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-78522022000200200Acta Ortopédica Brasileira v.30 n.2 2022reponame:Acta Ortopédica Brasileira (Online)instname:Sociedade Brasileira de Ortopedia e Traumatologia (SBOT)instacron:SBOT10.1590/1413-785220223002191015info:eu-repo/semantics/openAccessBARROS,THIAGO FELIPE DOS SANTOSPAULOS,RENATA GREGORIOIWASE,FERNANDA DO CARMOSANTOS,GUSTAVO BISPO DOSREZENDE,MARCELO ROSA DEMATTAR JÚNIOR,RAMESeng2022-06-03T00:00:00Zoai:scielo:S1413-78522022000200200Revistahttp://www.actaortopedica.com.br/https://old.scielo.br/oai/scielo-oai.php1atha@uol.com.br||actaortopedicabrasileira@uol.com.br1809-44061413-7852opendoar:2022-06-03T00:00Acta Ortopédica Brasileira (Online) - Sociedade Brasileira de Ortopedia e Traumatologia (SBOT)false
dc.title.none.fl_str_mv EFFECT OF HYPERBARIC OXYGEN THERAPY ON NERVE REGENERATION IN RATS
title EFFECT OF HYPERBARIC OXYGEN THERAPY ON NERVE REGENERATION IN RATS
spellingShingle EFFECT OF HYPERBARIC OXYGEN THERAPY ON NERVE REGENERATION IN RATS
BARROS,THIAGO FELIPE DOS SANTOS
Peripheral Nerves
Hyperbaric Oxygenation
Nerve Regeneration
Rats
title_short EFFECT OF HYPERBARIC OXYGEN THERAPY ON NERVE REGENERATION IN RATS
title_full EFFECT OF HYPERBARIC OXYGEN THERAPY ON NERVE REGENERATION IN RATS
title_fullStr EFFECT OF HYPERBARIC OXYGEN THERAPY ON NERVE REGENERATION IN RATS
title_full_unstemmed EFFECT OF HYPERBARIC OXYGEN THERAPY ON NERVE REGENERATION IN RATS
title_sort EFFECT OF HYPERBARIC OXYGEN THERAPY ON NERVE REGENERATION IN RATS
author BARROS,THIAGO FELIPE DOS SANTOS
author_facet BARROS,THIAGO FELIPE DOS SANTOS
PAULOS,RENATA GREGORIO
IWASE,FERNANDA DO CARMO
SANTOS,GUSTAVO BISPO DOS
REZENDE,MARCELO ROSA DE
MATTAR JÚNIOR,RAMES
author_role author
author2 PAULOS,RENATA GREGORIO
IWASE,FERNANDA DO CARMO
SANTOS,GUSTAVO BISPO DOS
REZENDE,MARCELO ROSA DE
MATTAR JÚNIOR,RAMES
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv BARROS,THIAGO FELIPE DOS SANTOS
PAULOS,RENATA GREGORIO
IWASE,FERNANDA DO CARMO
SANTOS,GUSTAVO BISPO DOS
REZENDE,MARCELO ROSA DE
MATTAR JÚNIOR,RAMES
dc.subject.por.fl_str_mv Peripheral Nerves
Hyperbaric Oxygenation
Nerve Regeneration
Rats
topic Peripheral Nerves
Hyperbaric Oxygenation
Nerve Regeneration
Rats
description ABSTRACT Objective: To evaluate histological changes in peripheral nerves of rats after sciatic nerve neurorrhaphy, according to the time of exposure to hyperbaric oxygen chamber treatment. Methods: Twenty-five Wistar rats were divided into 5 groups according to the amount of exposure to hyperbaric oxygen chamber treatment. Group 1 was the control and there was no use of hyperbaric oxygen chamber; group 2 received one week of therapy; group 3, two weeks; group 4, three weeks; and group 5, four weeks. After the fourth postoperative week, the animals were submitted to euthanasia and a sciatic nerve sample sent for histological analysis. Axons proximal and distal to the neurorrhaphy were counted with axonal regeneration index measurement. Results: We observed that the number of axons distal to neurorrhaphy increases with the amount of hyperbaric oxygen chamber exposure, the results were more expressive from the third week of treatment. However, the statistical analysis found no significant difference between the groups. Conclusion: The descriptive analysis suggests benefit of using hyperbaric oxygen chamber directly proportional to the time of therapy. The study, however, did not present statistically relevant results, probably due to the reduced sample size. Subsequent studies with more significant sampling would be of great value. Level of Evidence II, Prospective Comparative Study.
publishDate 2022
dc.date.none.fl_str_mv 2022-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-78522022000200200
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-78522022000200200
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/1413-785220223002191015
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv ATHA EDITORA
publisher.none.fl_str_mv ATHA EDITORA
dc.source.none.fl_str_mv Acta Ortopédica Brasileira v.30 n.2 2022
reponame:Acta Ortopédica Brasileira (Online)
instname:Sociedade Brasileira de Ortopedia e Traumatologia (SBOT)
instacron:SBOT
instname_str Sociedade Brasileira de Ortopedia e Traumatologia (SBOT)
instacron_str SBOT
institution SBOT
reponame_str Acta Ortopédica Brasileira (Online)
collection Acta Ortopédica Brasileira (Online)
repository.name.fl_str_mv Acta Ortopédica Brasileira (Online) - Sociedade Brasileira de Ortopedia e Traumatologia (SBOT)
repository.mail.fl_str_mv 1atha@uol.com.br||actaortopedicabrasileira@uol.com.br
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