Malignant transformation in chronic osteomyelitis

Detalhes bibliográficos
Autor(a) principal: Moura,Diogo Lino
Data de Publicação: 2017
Outros Autores: Ferreira,Rui, Garruço,António
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Ortopedia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-36162017000200141
Resumo: ABSTRACT INTRODUCTION: Carcinomatous degeneration is a rare and late complication developing decades after the diagnosis of chronic osteomyelitis. OBJECTIVES: To present the results from a retrospective study of six cases of squamous cell carcinoma arising from chronic osteomyelitis. METHODS: Six cases of chronic osteomyelitis related to cutaneous squamous cell carcinoma were identified. The cause and characteristics of the osteomyelitis were analyzed, as well as time up to malignancy, the suspicion signs for malignancy, the localization and histological type of the cancer, and the type and result of the treatment. RESULTS: The mean time between osteomyelitis onset and the diagnosis of malignant degeneration was 49.17 years (range: 32-65). The carcinoma resulted from tibia osteomyelitis in five cases and from femur osteomyelitis in one. The pathological examination indicated cutaneous squamous cell carcinoma in all cases. All the patients were staged as N0M0, except for one, whose lomboaortic lymph nodes were affected. The treatment consisted of amputation proximal to the tumor in all patients. No patient presented signs of local recurrence and only one had carcinoma metastasis. CONCLUSION: Early diagnosis and proximal amputation are essential for prognosis and final results in carcinomatous degeneration secondary to chronic osteomyelitis.
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spelling Malignant transformation in chronic osteomyelitisOsteomyelitisMalignant tumorsSquamous cell carcinomaNeoplasic cell transformationABSTRACT INTRODUCTION: Carcinomatous degeneration is a rare and late complication developing decades after the diagnosis of chronic osteomyelitis. OBJECTIVES: To present the results from a retrospective study of six cases of squamous cell carcinoma arising from chronic osteomyelitis. METHODS: Six cases of chronic osteomyelitis related to cutaneous squamous cell carcinoma were identified. The cause and characteristics of the osteomyelitis were analyzed, as well as time up to malignancy, the suspicion signs for malignancy, the localization and histological type of the cancer, and the type and result of the treatment. RESULTS: The mean time between osteomyelitis onset and the diagnosis of malignant degeneration was 49.17 years (range: 32-65). The carcinoma resulted from tibia osteomyelitis in five cases and from femur osteomyelitis in one. The pathological examination indicated cutaneous squamous cell carcinoma in all cases. All the patients were staged as N0M0, except for one, whose lomboaortic lymph nodes were affected. The treatment consisted of amputation proximal to the tumor in all patients. No patient presented signs of local recurrence and only one had carcinoma metastasis. CONCLUSION: Early diagnosis and proximal amputation are essential for prognosis and final results in carcinomatous degeneration secondary to chronic osteomyelitis.Sociedade Brasileira de Ortopedia e Traumatologia2017-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-36162017000200141Revista Brasileira de Ortopedia v.52 n.2 2017reponame:Revista Brasileira de Ortopedia (Online)instname:Sociedade Brasileira de Ortopedia e Traumatologia (SBOT)instacron:SBOT10.1016/j.rboe.2017.03.005info:eu-repo/semantics/openAccessMoura,Diogo LinoFerreira,RuiGarruço,Antónioeng2017-05-04T00:00:00Zoai:scielo:S0102-36162017000200141Revistahttp://www.rbo.org.br/https://old.scielo.br/oai/scielo-oai.php||rbo@sbot.org.br1982-43780102-3616opendoar:2017-05-04T00:00Revista Brasileira de Ortopedia (Online) - Sociedade Brasileira de Ortopedia e Traumatologia (SBOT)false
dc.title.none.fl_str_mv Malignant transformation in chronic osteomyelitis
title Malignant transformation in chronic osteomyelitis
spellingShingle Malignant transformation in chronic osteomyelitis
Moura,Diogo Lino
Osteomyelitis
Malignant tumors
Squamous cell carcinoma
Neoplasic cell transformation
title_short Malignant transformation in chronic osteomyelitis
title_full Malignant transformation in chronic osteomyelitis
title_fullStr Malignant transformation in chronic osteomyelitis
title_full_unstemmed Malignant transformation in chronic osteomyelitis
title_sort Malignant transformation in chronic osteomyelitis
author Moura,Diogo Lino
author_facet Moura,Diogo Lino
Ferreira,Rui
Garruço,António
author_role author
author2 Ferreira,Rui
Garruço,António
author2_role author
author
dc.contributor.author.fl_str_mv Moura,Diogo Lino
Ferreira,Rui
Garruço,António
dc.subject.por.fl_str_mv Osteomyelitis
Malignant tumors
Squamous cell carcinoma
Neoplasic cell transformation
topic Osteomyelitis
Malignant tumors
Squamous cell carcinoma
Neoplasic cell transformation
description ABSTRACT INTRODUCTION: Carcinomatous degeneration is a rare and late complication developing decades after the diagnosis of chronic osteomyelitis. OBJECTIVES: To present the results from a retrospective study of six cases of squamous cell carcinoma arising from chronic osteomyelitis. METHODS: Six cases of chronic osteomyelitis related to cutaneous squamous cell carcinoma were identified. The cause and characteristics of the osteomyelitis were analyzed, as well as time up to malignancy, the suspicion signs for malignancy, the localization and histological type of the cancer, and the type and result of the treatment. RESULTS: The mean time between osteomyelitis onset and the diagnosis of malignant degeneration was 49.17 years (range: 32-65). The carcinoma resulted from tibia osteomyelitis in five cases and from femur osteomyelitis in one. The pathological examination indicated cutaneous squamous cell carcinoma in all cases. All the patients were staged as N0M0, except for one, whose lomboaortic lymph nodes were affected. The treatment consisted of amputation proximal to the tumor in all patients. No patient presented signs of local recurrence and only one had carcinoma metastasis. CONCLUSION: Early diagnosis and proximal amputation are essential for prognosis and final results in carcinomatous degeneration secondary to chronic osteomyelitis.
publishDate 2017
dc.date.none.fl_str_mv 2017-03-01
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dc.language.iso.fl_str_mv eng
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dc.relation.none.fl_str_mv 10.1016/j.rboe.2017.03.005
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dc.publisher.none.fl_str_mv Sociedade Brasileira de Ortopedia e Traumatologia
publisher.none.fl_str_mv Sociedade Brasileira de Ortopedia e Traumatologia
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reponame:Revista Brasileira de Ortopedia (Online)
instname:Sociedade Brasileira de Ortopedia e Traumatologia (SBOT)
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