Nonalcoholic fatty liver disease: histopathological evaluation and interobserver agreement

Detalhes bibliográficos
Autor(a) principal: Berenstein,Cynthia Koeppel
Data de Publicação: 2008
Outros Autores: Cardoso,Caroline Guimarães, Toppa,Nivaldo Hartung, Leite,Virginia Hora Rios
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442008000100008
Resumo: BACKGROUND: Nonalcoholic fatty liver disease comprises a spectrum of lesions ranging from steatosis to cirrhosis, with nonalcoholic steatohepatitis being the progressive form of the disease. Alcohol intake, viral hepatitis and other liver diseases must be excluded. Liver biopsy is the gold standard for diagnosis of the disease and is the only method able to differentiate nonalcoholic steatohepatitis from simple steatosis, to grade inflammation and to stage fibrosis. AIMS: To analyze the histopathological findings and evaluate interobserver agreement in biopsies previously diagnosed as steatosis or steatohepatitis. METHODS: Seventy needle biopsies were analyzed according to Brunt et al.(4), with modifications in the grading and staging components. Clinical data of patients were collected. Interobserver agreement was calculated based on histopathological findings. RESULTS: Mild nonalcoholic steatohepatitis (grade 1) was the most common form. If fibrosis was detected, stage 1 was the most frequent. Interobserver agreement was very good for macrovesicular steatosis (K W = 0,82) and good for lobular inflammation (K W = 0,68) and fibrosis (K W = 0,73). CONCLUSIONS: The classification of Brunt et al., with modifications, can be applied to diagnosis not only of nonalcoholic steatohepatitis but also of nonalcoholic fatty liver disease, representing a reliable method for use in the daily practice of pathologists.
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spelling Nonalcoholic fatty liver disease: histopathological evaluation and interobserver agreementNonalcoholic steatohepatitisNonalcoholic fatty liver diseaseSteatosisLiverBACKGROUND: Nonalcoholic fatty liver disease comprises a spectrum of lesions ranging from steatosis to cirrhosis, with nonalcoholic steatohepatitis being the progressive form of the disease. Alcohol intake, viral hepatitis and other liver diseases must be excluded. Liver biopsy is the gold standard for diagnosis of the disease and is the only method able to differentiate nonalcoholic steatohepatitis from simple steatosis, to grade inflammation and to stage fibrosis. AIMS: To analyze the histopathological findings and evaluate interobserver agreement in biopsies previously diagnosed as steatosis or steatohepatitis. METHODS: Seventy needle biopsies were analyzed according to Brunt et al.(4), with modifications in the grading and staging components. Clinical data of patients were collected. Interobserver agreement was calculated based on histopathological findings. RESULTS: Mild nonalcoholic steatohepatitis (grade 1) was the most common form. If fibrosis was detected, stage 1 was the most frequent. Interobserver agreement was very good for macrovesicular steatosis (K W = 0,82) and good for lobular inflammation (K W = 0,68) and fibrosis (K W = 0,73). CONCLUSIONS: The classification of Brunt et al., with modifications, can be applied to diagnosis not only of nonalcoholic steatohepatitis but also of nonalcoholic fatty liver disease, representing a reliable method for use in the daily practice of pathologists.Sociedade Brasileira de Patologia Clínica2008-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442008000100008Jornal Brasileiro de Patologia e Medicina Laboratorial v.44 n.1 2008reponame:Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)instname:Sociedade Brasileira de Patologia (SBP)instacron:SBP10.1590/S1676-24442008000100008info:eu-repo/semantics/openAccessBerenstein,Cynthia KoeppelCardoso,Caroline GuimarãesToppa,Nivaldo HartungLeite,Virginia Hora Rioseng2008-05-14T00:00:00Zoai:scielo:S1676-24442008000100008Revistahttp://www.scielo.br/jbpmlhttps://old.scielo.br/oai/scielo-oai.php||jbpml@sbpc.org.br1678-47741676-2444opendoar:2008-05-14T00:00Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) - Sociedade Brasileira de Patologia (SBP)false
dc.title.none.fl_str_mv Nonalcoholic fatty liver disease: histopathological evaluation and interobserver agreement
title Nonalcoholic fatty liver disease: histopathological evaluation and interobserver agreement
spellingShingle Nonalcoholic fatty liver disease: histopathological evaluation and interobserver agreement
Berenstein,Cynthia Koeppel
Nonalcoholic steatohepatitis
Nonalcoholic fatty liver disease
Steatosis
Liver
title_short Nonalcoholic fatty liver disease: histopathological evaluation and interobserver agreement
title_full Nonalcoholic fatty liver disease: histopathological evaluation and interobserver agreement
title_fullStr Nonalcoholic fatty liver disease: histopathological evaluation and interobserver agreement
title_full_unstemmed Nonalcoholic fatty liver disease: histopathological evaluation and interobserver agreement
title_sort Nonalcoholic fatty liver disease: histopathological evaluation and interobserver agreement
author Berenstein,Cynthia Koeppel
author_facet Berenstein,Cynthia Koeppel
Cardoso,Caroline Guimarães
Toppa,Nivaldo Hartung
Leite,Virginia Hora Rios
author_role author
author2 Cardoso,Caroline Guimarães
Toppa,Nivaldo Hartung
Leite,Virginia Hora Rios
author2_role author
author
author
dc.contributor.author.fl_str_mv Berenstein,Cynthia Koeppel
Cardoso,Caroline Guimarães
Toppa,Nivaldo Hartung
Leite,Virginia Hora Rios
dc.subject.por.fl_str_mv Nonalcoholic steatohepatitis
Nonalcoholic fatty liver disease
Steatosis
Liver
topic Nonalcoholic steatohepatitis
Nonalcoholic fatty liver disease
Steatosis
Liver
description BACKGROUND: Nonalcoholic fatty liver disease comprises a spectrum of lesions ranging from steatosis to cirrhosis, with nonalcoholic steatohepatitis being the progressive form of the disease. Alcohol intake, viral hepatitis and other liver diseases must be excluded. Liver biopsy is the gold standard for diagnosis of the disease and is the only method able to differentiate nonalcoholic steatohepatitis from simple steatosis, to grade inflammation and to stage fibrosis. AIMS: To analyze the histopathological findings and evaluate interobserver agreement in biopsies previously diagnosed as steatosis or steatohepatitis. METHODS: Seventy needle biopsies were analyzed according to Brunt et al.(4), with modifications in the grading and staging components. Clinical data of patients were collected. Interobserver agreement was calculated based on histopathological findings. RESULTS: Mild nonalcoholic steatohepatitis (grade 1) was the most common form. If fibrosis was detected, stage 1 was the most frequent. Interobserver agreement was very good for macrovesicular steatosis (K W = 0,82) and good for lobular inflammation (K W = 0,68) and fibrosis (K W = 0,73). CONCLUSIONS: The classification of Brunt et al., with modifications, can be applied to diagnosis not only of nonalcoholic steatohepatitis but also of nonalcoholic fatty liver disease, representing a reliable method for use in the daily practice of pathologists.
publishDate 2008
dc.date.none.fl_str_mv 2008-02-01
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442008000100008
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dc.language.iso.fl_str_mv eng
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dc.relation.none.fl_str_mv 10.1590/S1676-24442008000100008
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dc.publisher.none.fl_str_mv
Sociedade Brasileira de Patologia Clínica
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Sociedade Brasileira de Patologia Clínica
dc.source.none.fl_str_mv Jornal Brasileiro de Patologia e Medicina Laboratorial v.44 n.1 2008
reponame:Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
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