The importance of homocysteine levels in the prognosis of patients with chronic renal disease and in hemodialysis patients

Detalhes bibliográficos
Autor(a) principal: Martella,Bruna M.
Data de Publicação: 2018
Outros Autores: Veiga,Glaucia Raquel L., Alves,Beatriz C. A., Azzalis,Ligia A., Junqueira,Virginia B. C., Gehrkei,Flavia S., Fonseca,Fernando Luiz A., Bacci,Marcelo R.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442018000300170
Resumo: ABSTRACT Introduction: Homocysteine (Hcy) is one of the metabolites of methionine (Met), an essential diet-derived amino acid. There is a close relationship between high plasma Hcy levels and declining renal function. Plasma and urinary Hcy level has been the target of studies as a biomarker that forecasts poor outcome in renal patients and in hemodialysis patients. This review evaluates the main studies that sought to correlate Hcy and poor prognosis in renal disease as well as the treatments proposed for the reduction of plasma Hcy levels in these patients. Conclusion: Hcy could be an important biomarker of renal disease progression mainly in hemodialysis patients. We emphasize the importance of normalizing plasma levels of this amino acid to ensure a better prognosis in kidney disease.
id SBP-1_50497357a58b500dbda7a5327844f12e
oai_identifier_str oai:scielo:S1676-24442018000300170
network_acronym_str SBP-1
network_name_str Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
repository_id_str
spelling The importance of homocysteine levels in the prognosis of patients with chronic renal disease and in hemodialysis patientshomocysteinemetabolismchronic kidney failureABSTRACT Introduction: Homocysteine (Hcy) is one of the metabolites of methionine (Met), an essential diet-derived amino acid. There is a close relationship between high plasma Hcy levels and declining renal function. Plasma and urinary Hcy level has been the target of studies as a biomarker that forecasts poor outcome in renal patients and in hemodialysis patients. This review evaluates the main studies that sought to correlate Hcy and poor prognosis in renal disease as well as the treatments proposed for the reduction of plasma Hcy levels in these patients. Conclusion: Hcy could be an important biomarker of renal disease progression mainly in hemodialysis patients. We emphasize the importance of normalizing plasma levels of this amino acid to ensure a better prognosis in kidney disease.Sociedade Brasileira de Patologia Clínica2018-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442018000300170Jornal Brasileiro de Patologia e Medicina Laboratorial v.54 n.3 2018reponame:Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)instname:Sociedade Brasileira de Patologia (SBP)instacron:SBP10.5935/1676-2444.20180030info:eu-repo/semantics/openAccessMartella,Bruna M.Veiga,Glaucia Raquel L.Alves,Beatriz C. A.Azzalis,Ligia A.Junqueira,Virginia B. C.Gehrkei,Flavia S.Fonseca,Fernando Luiz A.Bacci,Marcelo R.eng2018-08-08T00:00:00Zoai:scielo:S1676-24442018000300170Revistahttp://www.scielo.br/jbpmlhttps://old.scielo.br/oai/scielo-oai.php||jbpml@sbpc.org.br1678-47741676-2444opendoar:2018-08-08T00:00Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) - Sociedade Brasileira de Patologia (SBP)false
dc.title.none.fl_str_mv The importance of homocysteine levels in the prognosis of patients with chronic renal disease and in hemodialysis patients
title The importance of homocysteine levels in the prognosis of patients with chronic renal disease and in hemodialysis patients
spellingShingle The importance of homocysteine levels in the prognosis of patients with chronic renal disease and in hemodialysis patients
Martella,Bruna M.
homocysteine
metabolism
chronic kidney failure
title_short The importance of homocysteine levels in the prognosis of patients with chronic renal disease and in hemodialysis patients
title_full The importance of homocysteine levels in the prognosis of patients with chronic renal disease and in hemodialysis patients
title_fullStr The importance of homocysteine levels in the prognosis of patients with chronic renal disease and in hemodialysis patients
title_full_unstemmed The importance of homocysteine levels in the prognosis of patients with chronic renal disease and in hemodialysis patients
title_sort The importance of homocysteine levels in the prognosis of patients with chronic renal disease and in hemodialysis patients
author Martella,Bruna M.
author_facet Martella,Bruna M.
Veiga,Glaucia Raquel L.
Alves,Beatriz C. A.
Azzalis,Ligia A.
Junqueira,Virginia B. C.
Gehrkei,Flavia S.
Fonseca,Fernando Luiz A.
Bacci,Marcelo R.
author_role author
author2 Veiga,Glaucia Raquel L.
Alves,Beatriz C. A.
Azzalis,Ligia A.
Junqueira,Virginia B. C.
Gehrkei,Flavia S.
Fonseca,Fernando Luiz A.
Bacci,Marcelo R.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Martella,Bruna M.
Veiga,Glaucia Raquel L.
Alves,Beatriz C. A.
Azzalis,Ligia A.
Junqueira,Virginia B. C.
Gehrkei,Flavia S.
Fonseca,Fernando Luiz A.
Bacci,Marcelo R.
dc.subject.por.fl_str_mv homocysteine
metabolism
chronic kidney failure
topic homocysteine
metabolism
chronic kidney failure
description ABSTRACT Introduction: Homocysteine (Hcy) is one of the metabolites of methionine (Met), an essential diet-derived amino acid. There is a close relationship between high plasma Hcy levels and declining renal function. Plasma and urinary Hcy level has been the target of studies as a biomarker that forecasts poor outcome in renal patients and in hemodialysis patients. This review evaluates the main studies that sought to correlate Hcy and poor prognosis in renal disease as well as the treatments proposed for the reduction of plasma Hcy levels in these patients. Conclusion: Hcy could be an important biomarker of renal disease progression mainly in hemodialysis patients. We emphasize the importance of normalizing plasma levels of this amino acid to ensure a better prognosis in kidney disease.
publishDate 2018
dc.date.none.fl_str_mv 2018-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442018000300170
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442018000300170
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/1676-2444.20180030
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv
Sociedade Brasileira de Patologia Clínica
publisher.none.fl_str_mv
Sociedade Brasileira de Patologia Clínica
dc.source.none.fl_str_mv Jornal Brasileiro de Patologia e Medicina Laboratorial v.54 n.3 2018
reponame:Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
instname:Sociedade Brasileira de Patologia (SBP)
instacron:SBP
instname_str Sociedade Brasileira de Patologia (SBP)
instacron_str SBP
institution SBP
reponame_str Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
collection Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
repository.name.fl_str_mv Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) - Sociedade Brasileira de Patologia (SBP)
repository.mail.fl_str_mv ||jbpml@sbpc.org.br
_version_ 1752122297119932416

Registros relacionados