Utility of tissue microarrays MIB-1 for profiling prognostic biomarkers in clinically localized prostate cancer
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442009000600010 |
Resumo: | INTRODUCTION AND OBJECTIVE: To analyze the immuno-histochemical expression of MIB-1 marker as a prognostic factor in patients with localized prostate neoplasia. METHODS: Analysis of 100 cases of patients with localized prostate neoplasia who underwent curative surgery from January 2000 to December 2006. The customary histological preparation was carried out, followed by immunohistochemical reaction to detect MIB-1 protein accumulation and statistical analysis. RESULTS: There was a larger proportion of negative expression for MIB-1 marker (63.0%, p < 0.0001). Patients with positive expression (MIB-1 positive) had higher PSA (PSA > 10 ng/dl) (p = 0.010), higher Gleason score (> 7) (p = 0.0003) and pathological stage pT2c (p = 0.001). In the comparison of variables, it was noticed that patients with positive expression had a higher mean PSA (p = 0.031), higher Gleason score (p < 0.0001), longer follow-up (p = 0.037), larger area of vascular proliferation (p < 0.0001) and higher proportion of tumor in relation to normal area (p = 0.012). CONCLUSION: MIB-1 proved to be a prognostic factor comparable to PSA, Gleason and staging. |
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Utility of tissue microarrays MIB-1 for profiling prognostic biomarkers in clinically localized prostate cancerProstatectomyProstate neoplasmMIB-1 antibodyINTRODUCTION AND OBJECTIVE: To analyze the immuno-histochemical expression of MIB-1 marker as a prognostic factor in patients with localized prostate neoplasia. METHODS: Analysis of 100 cases of patients with localized prostate neoplasia who underwent curative surgery from January 2000 to December 2006. The customary histological preparation was carried out, followed by immunohistochemical reaction to detect MIB-1 protein accumulation and statistical analysis. RESULTS: There was a larger proportion of negative expression for MIB-1 marker (63.0%, p < 0.0001). Patients with positive expression (MIB-1 positive) had higher PSA (PSA > 10 ng/dl) (p = 0.010), higher Gleason score (> 7) (p = 0.0003) and pathological stage pT2c (p = 0.001). In the comparison of variables, it was noticed that patients with positive expression had a higher mean PSA (p = 0.031), higher Gleason score (p < 0.0001), longer follow-up (p = 0.037), larger area of vascular proliferation (p < 0.0001) and higher proportion of tumor in relation to normal area (p = 0.012). CONCLUSION: MIB-1 proved to be a prognostic factor comparable to PSA, Gleason and staging.Sociedade Brasileira de Patologia Clínica2009-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442009000600010Jornal Brasileiro de Patologia e Medicina Laboratorial v.45 n.6 2009reponame:Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)instname:Sociedade Brasileira de Patologia (SBP)instacron:SBP10.1590/S1676-24442009000600010info:eu-repo/semantics/openAccessNassif,Aissar EduardoTambara Filho,RenatoPaula,Regina Xavier Gomes Deeng2010-04-26T00:00:00Zoai:scielo:S1676-24442009000600010Revistahttp://www.scielo.br/jbpmlhttps://old.scielo.br/oai/scielo-oai.php||jbpml@sbpc.org.br1678-47741676-2444opendoar:2010-04-26T00:00Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) - Sociedade Brasileira de Patologia (SBP)false |
dc.title.none.fl_str_mv |
Utility of tissue microarrays MIB-1 for profiling prognostic biomarkers in clinically localized prostate cancer |
title |
Utility of tissue microarrays MIB-1 for profiling prognostic biomarkers in clinically localized prostate cancer |
spellingShingle |
Utility of tissue microarrays MIB-1 for profiling prognostic biomarkers in clinically localized prostate cancer Nassif,Aissar Eduardo Prostatectomy Prostate neoplasm MIB-1 antibody |
title_short |
Utility of tissue microarrays MIB-1 for profiling prognostic biomarkers in clinically localized prostate cancer |
title_full |
Utility of tissue microarrays MIB-1 for profiling prognostic biomarkers in clinically localized prostate cancer |
title_fullStr |
Utility of tissue microarrays MIB-1 for profiling prognostic biomarkers in clinically localized prostate cancer |
title_full_unstemmed |
Utility of tissue microarrays MIB-1 for profiling prognostic biomarkers in clinically localized prostate cancer |
title_sort |
Utility of tissue microarrays MIB-1 for profiling prognostic biomarkers in clinically localized prostate cancer |
author |
Nassif,Aissar Eduardo |
author_facet |
Nassif,Aissar Eduardo Tambara Filho,Renato Paula,Regina Xavier Gomes De |
author_role |
author |
author2 |
Tambara Filho,Renato Paula,Regina Xavier Gomes De |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Nassif,Aissar Eduardo Tambara Filho,Renato Paula,Regina Xavier Gomes De |
dc.subject.por.fl_str_mv |
Prostatectomy Prostate neoplasm MIB-1 antibody |
topic |
Prostatectomy Prostate neoplasm MIB-1 antibody |
description |
INTRODUCTION AND OBJECTIVE: To analyze the immuno-histochemical expression of MIB-1 marker as a prognostic factor in patients with localized prostate neoplasia. METHODS: Analysis of 100 cases of patients with localized prostate neoplasia who underwent curative surgery from January 2000 to December 2006. The customary histological preparation was carried out, followed by immunohistochemical reaction to detect MIB-1 protein accumulation and statistical analysis. RESULTS: There was a larger proportion of negative expression for MIB-1 marker (63.0%, p < 0.0001). Patients with positive expression (MIB-1 positive) had higher PSA (PSA > 10 ng/dl) (p = 0.010), higher Gleason score (> 7) (p = 0.0003) and pathological stage pT2c (p = 0.001). In the comparison of variables, it was noticed that patients with positive expression had a higher mean PSA (p = 0.031), higher Gleason score (p < 0.0001), longer follow-up (p = 0.037), larger area of vascular proliferation (p < 0.0001) and higher proportion of tumor in relation to normal area (p = 0.012). CONCLUSION: MIB-1 proved to be a prognostic factor comparable to PSA, Gleason and staging. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442009000600010 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442009000600010 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1676-24442009000600010 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Patologia Clínica |
publisher.none.fl_str_mv |
Sociedade Brasileira de Patologia Clínica |
dc.source.none.fl_str_mv |
Jornal Brasileiro de Patologia e Medicina Laboratorial v.45 n.6 2009 reponame:Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) instname:Sociedade Brasileira de Patologia (SBP) instacron:SBP |
instname_str |
Sociedade Brasileira de Patologia (SBP) |
instacron_str |
SBP |
institution |
SBP |
reponame_str |
Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) |
collection |
Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) |
repository.name.fl_str_mv |
Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) - Sociedade Brasileira de Patologia (SBP) |
repository.mail.fl_str_mv |
||jbpml@sbpc.org.br |
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1752122294940991488 |