Invasive mechanical ventilation and biomarkers as predictors of bronchopulmonary dysplasia in preterm infants
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Publication Date: | 2021 |
Other Authors: | , , , , , , , |
Format: | Article |
Language: | eng |
Source: | Jornal de Pediatria (Online) |
Download full: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572021000300280 |
Summary: | Abstract Objectives To evaluate the impact of invasive mechanical ventilation associated with two serum inflammatory cytokines and clinical indicators, on the second day of life, as predictors of bronchopulmonary dysplasia in very low birth weight preterm infants. It was hypothesized that the use of invasive mechanical ventilation in the first hours of life is associated with biomarkers that may predict the chances of preterm infants to develop bronchopulmonary dysplasia. Methods Prospective cohort of 40 preterm infants with gestational age <34 weeks and birth weight <1500 g. The following were analyzed: clinical variables; types of ventilator support used (there is a higher occurrence of bronchopulmonary dysplasia when oxygen supplementation is performed by long periods of invasive mechanical ventilation); hospitalization time; quantification of two cytokines (granulocyte and macrophage colony stimulating factor [GM-CSF] and eotaxin) in blood between 36 and 48 h of life. The preterm infants were divided in two groups: with and without bronchopulmonary dysplasia. Results The GM-CSF levels presented a significantly higher value in the bronchopulmonary dysplasia group (p = 0.002), while eotaxin presented higher levels in the group without bronchopulmonary dysplasia (p = 0.02). The use of continuous invasive mechanical ventilation was associated with increased ratios between GM-CSF and eotaxin (100% sensitivity and 80% specificity; receiver operating characteristic area = 0.9013, CI = 0.7791–1.024, p < 0.0001). Conclusions The duration of invasive mechanical ventilation performed in the first 48 h of life in the very low birth weight infants is a significant clinical predictor of bronchopulmonary dysplasia. The use of continuous invasive mechanical ventilation was associated with increased ratios between GM-CSF and eotaxin, suggesting increased lung injury and consequent progression of the disease. |
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Invasive mechanical ventilation and biomarkers as predictors of bronchopulmonary dysplasia in preterm infantsInfant, very low birth weightPremature birthNeonatologyLung diseasesVentilator-induced lung injuryAbstract Objectives To evaluate the impact of invasive mechanical ventilation associated with two serum inflammatory cytokines and clinical indicators, on the second day of life, as predictors of bronchopulmonary dysplasia in very low birth weight preterm infants. It was hypothesized that the use of invasive mechanical ventilation in the first hours of life is associated with biomarkers that may predict the chances of preterm infants to develop bronchopulmonary dysplasia. Methods Prospective cohort of 40 preterm infants with gestational age <34 weeks and birth weight <1500 g. The following were analyzed: clinical variables; types of ventilator support used (there is a higher occurrence of bronchopulmonary dysplasia when oxygen supplementation is performed by long periods of invasive mechanical ventilation); hospitalization time; quantification of two cytokines (granulocyte and macrophage colony stimulating factor [GM-CSF] and eotaxin) in blood between 36 and 48 h of life. The preterm infants were divided in two groups: with and without bronchopulmonary dysplasia. Results The GM-CSF levels presented a significantly higher value in the bronchopulmonary dysplasia group (p = 0.002), while eotaxin presented higher levels in the group without bronchopulmonary dysplasia (p = 0.02). The use of continuous invasive mechanical ventilation was associated with increased ratios between GM-CSF and eotaxin (100% sensitivity and 80% specificity; receiver operating characteristic area = 0.9013, CI = 0.7791–1.024, p < 0.0001). Conclusions The duration of invasive mechanical ventilation performed in the first 48 h of life in the very low birth weight infants is a significant clinical predictor of bronchopulmonary dysplasia. The use of continuous invasive mechanical ventilation was associated with increased ratios between GM-CSF and eotaxin, suggesting increased lung injury and consequent progression of the disease.Sociedade Brasileira de Pediatria2021-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572021000300280Jornal de Pediatria v.97 n.3 2021reponame:Jornal de Pediatria (Online)instname:Sociedade Brasileira de Pediatria (SBP)instacron:SBPE10.1016/j.jped.2020.03.006info:eu-repo/semantics/openAccessNascimento,Camila PiquiMaia,Larissa PradoAlves,Patrícia TerraPaula,Aline Teodoro deCunha Junior,Jair PereiraAbdallah,Vânia Olivetti SteffenFerreira,Daniela Marques de Lima MotaGoulart,Luiz RicardoAzevedo,Vivian Mara Gonçalves de Oliveiraeng2021-06-30T00:00:00Zoai:scielo:S0021-75572021000300280Revistahttp://www.jped.com.br/https://old.scielo.br/oai/scielo-oai.php||jped@jped.com.br1678-47820021-7557opendoar:2021-06-30T00:00Jornal de Pediatria (Online) - Sociedade Brasileira de Pediatria (SBP)false |
dc.title.none.fl_str_mv |
Invasive mechanical ventilation and biomarkers as predictors of bronchopulmonary dysplasia in preterm infants |
title |
Invasive mechanical ventilation and biomarkers as predictors of bronchopulmonary dysplasia in preterm infants |
spellingShingle |
Invasive mechanical ventilation and biomarkers as predictors of bronchopulmonary dysplasia in preterm infants Nascimento,Camila Piqui Infant, very low birth weight Premature birth Neonatology Lung diseases Ventilator-induced lung injury |
title_short |
Invasive mechanical ventilation and biomarkers as predictors of bronchopulmonary dysplasia in preterm infants |
title_full |
Invasive mechanical ventilation and biomarkers as predictors of bronchopulmonary dysplasia in preterm infants |
title_fullStr |
Invasive mechanical ventilation and biomarkers as predictors of bronchopulmonary dysplasia in preterm infants |
title_full_unstemmed |
Invasive mechanical ventilation and biomarkers as predictors of bronchopulmonary dysplasia in preterm infants |
title_sort |
Invasive mechanical ventilation and biomarkers as predictors of bronchopulmonary dysplasia in preterm infants |
author |
Nascimento,Camila Piqui |
author_facet |
Nascimento,Camila Piqui Maia,Larissa Prado Alves,Patrícia Terra Paula,Aline Teodoro de Cunha Junior,Jair Pereira Abdallah,Vânia Olivetti Steffen Ferreira,Daniela Marques de Lima Mota Goulart,Luiz Ricardo Azevedo,Vivian Mara Gonçalves de Oliveira |
author_role |
author |
author2 |
Maia,Larissa Prado Alves,Patrícia Terra Paula,Aline Teodoro de Cunha Junior,Jair Pereira Abdallah,Vânia Olivetti Steffen Ferreira,Daniela Marques de Lima Mota Goulart,Luiz Ricardo Azevedo,Vivian Mara Gonçalves de Oliveira |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Nascimento,Camila Piqui Maia,Larissa Prado Alves,Patrícia Terra Paula,Aline Teodoro de Cunha Junior,Jair Pereira Abdallah,Vânia Olivetti Steffen Ferreira,Daniela Marques de Lima Mota Goulart,Luiz Ricardo Azevedo,Vivian Mara Gonçalves de Oliveira |
dc.subject.por.fl_str_mv |
Infant, very low birth weight Premature birth Neonatology Lung diseases Ventilator-induced lung injury |
topic |
Infant, very low birth weight Premature birth Neonatology Lung diseases Ventilator-induced lung injury |
description |
Abstract Objectives To evaluate the impact of invasive mechanical ventilation associated with two serum inflammatory cytokines and clinical indicators, on the second day of life, as predictors of bronchopulmonary dysplasia in very low birth weight preterm infants. It was hypothesized that the use of invasive mechanical ventilation in the first hours of life is associated with biomarkers that may predict the chances of preterm infants to develop bronchopulmonary dysplasia. Methods Prospective cohort of 40 preterm infants with gestational age <34 weeks and birth weight <1500 g. The following were analyzed: clinical variables; types of ventilator support used (there is a higher occurrence of bronchopulmonary dysplasia when oxygen supplementation is performed by long periods of invasive mechanical ventilation); hospitalization time; quantification of two cytokines (granulocyte and macrophage colony stimulating factor [GM-CSF] and eotaxin) in blood between 36 and 48 h of life. The preterm infants were divided in two groups: with and without bronchopulmonary dysplasia. Results The GM-CSF levels presented a significantly higher value in the bronchopulmonary dysplasia group (p = 0.002), while eotaxin presented higher levels in the group without bronchopulmonary dysplasia (p = 0.02). The use of continuous invasive mechanical ventilation was associated with increased ratios between GM-CSF and eotaxin (100% sensitivity and 80% specificity; receiver operating characteristic area = 0.9013, CI = 0.7791–1.024, p < 0.0001). Conclusions The duration of invasive mechanical ventilation performed in the first 48 h of life in the very low birth weight infants is a significant clinical predictor of bronchopulmonary dysplasia. The use of continuous invasive mechanical ventilation was associated with increased ratios between GM-CSF and eotaxin, suggesting increased lung injury and consequent progression of the disease. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572021000300280 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572021000300280 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.jped.2020.03.006 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Pediatria |
publisher.none.fl_str_mv |
Sociedade Brasileira de Pediatria |
dc.source.none.fl_str_mv |
Jornal de Pediatria v.97 n.3 2021 reponame:Jornal de Pediatria (Online) instname:Sociedade Brasileira de Pediatria (SBP) instacron:SBPE |
instname_str |
Sociedade Brasileira de Pediatria (SBP) |
instacron_str |
SBPE |
institution |
SBPE |
reponame_str |
Jornal de Pediatria (Online) |
collection |
Jornal de Pediatria (Online) |
repository.name.fl_str_mv |
Jornal de Pediatria (Online) - Sociedade Brasileira de Pediatria (SBP) |
repository.mail.fl_str_mv |
||jped@jped.com.br |
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1752122322747129856 |