Antimicrobial use for treatment of healthcare-associated infections and bacterial resistance in a reference neonatal unit
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Jornal de Pediatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572021000300329 |
Resumo: | Abstract Objective The use of broad-spectrum antimicrobials, such as third and fourth-generation, are responsible for emergence of multidrug-resistant microorganisms in neonatal units. Furthermore, antimicrobial daily doses are not standardized in neonatology. This study aimed to investigate the association between the use of antimicrobial broad spectrum to bacterial sensitivity profile in a referral unit of neonatal progressive care. Methods This is a cohort study conducted in a referral neonatal progressive care unit from January 2008 to December 2016. The data of all hospitalized neonates was collected daily. The infection criteria used were the standardized national criteria, based on definitions of Center for Diseases Control and Prevention. In this study, the use of antimicrobials was evaluated as antimicrobial-day (ATM-day) and the ratio of multidrug-resistant microorganisms per 1000 ATM-day of broad spectrum was also calculated. The study was approved by the Institutional Review Board of the Universidade Federal de Minas Gerais (ETIC 312/08 e CAAE 58973616.2.0000.5149). Results From 2008 to 2016, 2751 neonates were hospitalized, corresponding to 60,656 patient-days. The ratio of multidrug-resistant microorganisms per 1000 ATM-day of broad spectrum was 1,3 in the first period and 4,3 in the second period (p = 0,005). Conclusion It was observed that use of broad-spectrum antimicrobials, especially those with coverage for Gram-negative bacteria, was associated with an increase of multidrug-resistant bacteria. |
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Antimicrobial use for treatment of healthcare-associated infections and bacterial resistance in a reference neonatal unitNewbornInfantAnti-infective agentsDrug resistanceMicrobialInfection controlAbstract Objective The use of broad-spectrum antimicrobials, such as third and fourth-generation, are responsible for emergence of multidrug-resistant microorganisms in neonatal units. Furthermore, antimicrobial daily doses are not standardized in neonatology. This study aimed to investigate the association between the use of antimicrobial broad spectrum to bacterial sensitivity profile in a referral unit of neonatal progressive care. Methods This is a cohort study conducted in a referral neonatal progressive care unit from January 2008 to December 2016. The data of all hospitalized neonates was collected daily. The infection criteria used were the standardized national criteria, based on definitions of Center for Diseases Control and Prevention. In this study, the use of antimicrobials was evaluated as antimicrobial-day (ATM-day) and the ratio of multidrug-resistant microorganisms per 1000 ATM-day of broad spectrum was also calculated. The study was approved by the Institutional Review Board of the Universidade Federal de Minas Gerais (ETIC 312/08 e CAAE 58973616.2.0000.5149). Results From 2008 to 2016, 2751 neonates were hospitalized, corresponding to 60,656 patient-days. The ratio of multidrug-resistant microorganisms per 1000 ATM-day of broad spectrum was 1,3 in the first period and 4,3 in the second period (p = 0,005). Conclusion It was observed that use of broad-spectrum antimicrobials, especially those with coverage for Gram-negative bacteria, was associated with an increase of multidrug-resistant bacteria.Sociedade Brasileira de Pediatria2021-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572021000300329Jornal de Pediatria v.97 n.3 2021reponame:Jornal de Pediatria (Online)instname:Sociedade Brasileira de Pediatria (SBP)instacron:SBPE10.1016/j.jped.2020.06.001info:eu-repo/semantics/openAccessSilva,Ana Carolina Bueno eAnchieta,Leni MárciaRosado,VivianeFerreira,JanitaClemente,Wanessa TrindadeCoelho,Julia SampaioMourão,Paulo Henrique OrlandiRomanelli,Roberta Maia de Castroeng2021-06-30T00:00:00Zoai:scielo:S0021-75572021000300329Revistahttp://www.jped.com.br/https://old.scielo.br/oai/scielo-oai.php||jped@jped.com.br1678-47820021-7557opendoar:2021-06-30T00:00Jornal de Pediatria (Online) - Sociedade Brasileira de Pediatria (SBP)false |
dc.title.none.fl_str_mv |
Antimicrobial use for treatment of healthcare-associated infections and bacterial resistance in a reference neonatal unit |
title |
Antimicrobial use for treatment of healthcare-associated infections and bacterial resistance in a reference neonatal unit |
spellingShingle |
Antimicrobial use for treatment of healthcare-associated infections and bacterial resistance in a reference neonatal unit Silva,Ana Carolina Bueno e Newborn Infant Anti-infective agents Drug resistance Microbial Infection control |
title_short |
Antimicrobial use for treatment of healthcare-associated infections and bacterial resistance in a reference neonatal unit |
title_full |
Antimicrobial use for treatment of healthcare-associated infections and bacterial resistance in a reference neonatal unit |
title_fullStr |
Antimicrobial use for treatment of healthcare-associated infections and bacterial resistance in a reference neonatal unit |
title_full_unstemmed |
Antimicrobial use for treatment of healthcare-associated infections and bacterial resistance in a reference neonatal unit |
title_sort |
Antimicrobial use for treatment of healthcare-associated infections and bacterial resistance in a reference neonatal unit |
author |
Silva,Ana Carolina Bueno e |
author_facet |
Silva,Ana Carolina Bueno e Anchieta,Leni Márcia Rosado,Viviane Ferreira,Janita Clemente,Wanessa Trindade Coelho,Julia Sampaio Mourão,Paulo Henrique Orlandi Romanelli,Roberta Maia de Castro |
author_role |
author |
author2 |
Anchieta,Leni Márcia Rosado,Viviane Ferreira,Janita Clemente,Wanessa Trindade Coelho,Julia Sampaio Mourão,Paulo Henrique Orlandi Romanelli,Roberta Maia de Castro |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Silva,Ana Carolina Bueno e Anchieta,Leni Márcia Rosado,Viviane Ferreira,Janita Clemente,Wanessa Trindade Coelho,Julia Sampaio Mourão,Paulo Henrique Orlandi Romanelli,Roberta Maia de Castro |
dc.subject.por.fl_str_mv |
Newborn Infant Anti-infective agents Drug resistance Microbial Infection control |
topic |
Newborn Infant Anti-infective agents Drug resistance Microbial Infection control |
description |
Abstract Objective The use of broad-spectrum antimicrobials, such as third and fourth-generation, are responsible for emergence of multidrug-resistant microorganisms in neonatal units. Furthermore, antimicrobial daily doses are not standardized in neonatology. This study aimed to investigate the association between the use of antimicrobial broad spectrum to bacterial sensitivity profile in a referral unit of neonatal progressive care. Methods This is a cohort study conducted in a referral neonatal progressive care unit from January 2008 to December 2016. The data of all hospitalized neonates was collected daily. The infection criteria used were the standardized national criteria, based on definitions of Center for Diseases Control and Prevention. In this study, the use of antimicrobials was evaluated as antimicrobial-day (ATM-day) and the ratio of multidrug-resistant microorganisms per 1000 ATM-day of broad spectrum was also calculated. The study was approved by the Institutional Review Board of the Universidade Federal de Minas Gerais (ETIC 312/08 e CAAE 58973616.2.0000.5149). Results From 2008 to 2016, 2751 neonates were hospitalized, corresponding to 60,656 patient-days. The ratio of multidrug-resistant microorganisms per 1000 ATM-day of broad spectrum was 1,3 in the first period and 4,3 in the second period (p = 0,005). Conclusion It was observed that use of broad-spectrum antimicrobials, especially those with coverage for Gram-negative bacteria, was associated with an increase of multidrug-resistant bacteria. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572021000300329 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572021000300329 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.jped.2020.06.001 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Pediatria |
publisher.none.fl_str_mv |
Sociedade Brasileira de Pediatria |
dc.source.none.fl_str_mv |
Jornal de Pediatria v.97 n.3 2021 reponame:Jornal de Pediatria (Online) instname:Sociedade Brasileira de Pediatria (SBP) instacron:SBPE |
instname_str |
Sociedade Brasileira de Pediatria (SBP) |
instacron_str |
SBPE |
institution |
SBPE |
reponame_str |
Jornal de Pediatria (Online) |
collection |
Jornal de Pediatria (Online) |
repository.name.fl_str_mv |
Jornal de Pediatria (Online) - Sociedade Brasileira de Pediatria (SBP) |
repository.mail.fl_str_mv |
||jped@jped.com.br |
_version_ |
1752122322760761344 |