Effects of the association of antifungal drugs on the antimicrobial action of endodontic sealers
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Oral Research |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242015000100269 |
Resumo: | This in vitro study aimed to determine the susceptibility of oral specimens and ATCC lineages of Candida albicans for five endodontic sealers, which were pure and associated with two antifungal drugs, and to analyze their effect on the physical properties. For this purpose, 30 lineages of C. albicans, collected from the oral cavity of patients assisted at the endodontics clinic of the Universidade Sagrado Coração, were analyzed. Yeasts susceptibility to the sealers was tested by diffusion on agar plates. Physical properties were evaluated according to the ADA specification no. 57. The pure versions of the Sealer 26, AH Plus, Endofill, Fillapex, and Sealapex demonstrated antifungal activity, with Endofill presenting the greatest inhibition zones. All cements, except for Endofill, had their antifungal actions enhanced by addition of ketoconazole and fluconazole (p < 0.05), and the AH Plus presented the best antifungal activity. The addition of antifungal drugs did not interfere with the setting time and flowability of the sealers. It was concluded that the addition of antifungals to endodontic sealers enhanced the antimicrobial action of most cements tested without altering their physical properties. |
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Effects of the association of antifungal drugs on the antimicrobial action of endodontic sealersAntifungal AgentsPhysical PropertiesRoot Canal ObturationKetoconazoleFluconazoleThis in vitro study aimed to determine the susceptibility of oral specimens and ATCC lineages of Candida albicans for five endodontic sealers, which were pure and associated with two antifungal drugs, and to analyze their effect on the physical properties. For this purpose, 30 lineages of C. albicans, collected from the oral cavity of patients assisted at the endodontics clinic of the Universidade Sagrado Coração, were analyzed. Yeasts susceptibility to the sealers was tested by diffusion on agar plates. Physical properties were evaluated according to the ADA specification no. 57. The pure versions of the Sealer 26, AH Plus, Endofill, Fillapex, and Sealapex demonstrated antifungal activity, with Endofill presenting the greatest inhibition zones. All cements, except for Endofill, had their antifungal actions enhanced by addition of ketoconazole and fluconazole (p < 0.05), and the AH Plus presented the best antifungal activity. The addition of antifungal drugs did not interfere with the setting time and flowability of the sealers. It was concluded that the addition of antifungals to endodontic sealers enhanced the antimicrobial action of most cements tested without altering their physical properties.Sociedade Brasileira de Pesquisa Odontológica - SBPqO2015-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242015000100269Brazilian Oral Research v.29 n.1 2015reponame:Brazilian Oral Researchinstname:Sociedade Brasileira de Pesquisa Odontológica (SBPqO)instacron:SBPQO10.1590/1807-3107BOR-2015.vol29.0073info:eu-repo/semantics/openAccessWECKWERTH,Paulo HenriqueLIMA,Fellipe Lombardo de SouzaGREATTI,Vanessa RaquelDUARTE,Marco Antonio HungaroVIVAN,Rodrigo Riccieng2018-09-17T00:00:00Zoai:scielo:S1806-83242015000100269Revistahttps://www.scielo.br/j/bor/https://old.scielo.br/oai/scielo-oai.phppob@edu.usp.br||bor@sbpqo.org.br1807-31071806-8324opendoar:2018-09-17T00:00Brazilian Oral Research - Sociedade Brasileira de Pesquisa Odontológica (SBPqO)false |
dc.title.none.fl_str_mv |
Effects of the association of antifungal drugs on the antimicrobial action of endodontic sealers |
title |
Effects of the association of antifungal drugs on the antimicrobial action of endodontic sealers |
spellingShingle |
Effects of the association of antifungal drugs on the antimicrobial action of endodontic sealers WECKWERTH,Paulo Henrique Antifungal Agents Physical Properties Root Canal Obturation Ketoconazole Fluconazole |
title_short |
Effects of the association of antifungal drugs on the antimicrobial action of endodontic sealers |
title_full |
Effects of the association of antifungal drugs on the antimicrobial action of endodontic sealers |
title_fullStr |
Effects of the association of antifungal drugs on the antimicrobial action of endodontic sealers |
title_full_unstemmed |
Effects of the association of antifungal drugs on the antimicrobial action of endodontic sealers |
title_sort |
Effects of the association of antifungal drugs on the antimicrobial action of endodontic sealers |
author |
WECKWERTH,Paulo Henrique |
author_facet |
WECKWERTH,Paulo Henrique LIMA,Fellipe Lombardo de Souza GREATTI,Vanessa Raquel DUARTE,Marco Antonio Hungaro VIVAN,Rodrigo Ricci |
author_role |
author |
author2 |
LIMA,Fellipe Lombardo de Souza GREATTI,Vanessa Raquel DUARTE,Marco Antonio Hungaro VIVAN,Rodrigo Ricci |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
WECKWERTH,Paulo Henrique LIMA,Fellipe Lombardo de Souza GREATTI,Vanessa Raquel DUARTE,Marco Antonio Hungaro VIVAN,Rodrigo Ricci |
dc.subject.por.fl_str_mv |
Antifungal Agents Physical Properties Root Canal Obturation Ketoconazole Fluconazole |
topic |
Antifungal Agents Physical Properties Root Canal Obturation Ketoconazole Fluconazole |
description |
This in vitro study aimed to determine the susceptibility of oral specimens and ATCC lineages of Candida albicans for five endodontic sealers, which were pure and associated with two antifungal drugs, and to analyze their effect on the physical properties. For this purpose, 30 lineages of C. albicans, collected from the oral cavity of patients assisted at the endodontics clinic of the Universidade Sagrado Coração, were analyzed. Yeasts susceptibility to the sealers was tested by diffusion on agar plates. Physical properties were evaluated according to the ADA specification no. 57. The pure versions of the Sealer 26, AH Plus, Endofill, Fillapex, and Sealapex demonstrated antifungal activity, with Endofill presenting the greatest inhibition zones. All cements, except for Endofill, had their antifungal actions enhanced by addition of ketoconazole and fluconazole (p < 0.05), and the AH Plus presented the best antifungal activity. The addition of antifungal drugs did not interfere with the setting time and flowability of the sealers. It was concluded that the addition of antifungals to endodontic sealers enhanced the antimicrobial action of most cements tested without altering their physical properties. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242015000100269 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242015000100269 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1807-3107BOR-2015.vol29.0073 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Pesquisa Odontológica - SBPqO |
publisher.none.fl_str_mv |
Sociedade Brasileira de Pesquisa Odontológica - SBPqO |
dc.source.none.fl_str_mv |
Brazilian Oral Research v.29 n.1 2015 reponame:Brazilian Oral Research instname:Sociedade Brasileira de Pesquisa Odontológica (SBPqO) instacron:SBPQO |
instname_str |
Sociedade Brasileira de Pesquisa Odontológica (SBPqO) |
instacron_str |
SBPQO |
institution |
SBPQO |
reponame_str |
Brazilian Oral Research |
collection |
Brazilian Oral Research |
repository.name.fl_str_mv |
Brazilian Oral Research - Sociedade Brasileira de Pesquisa Odontológica (SBPqO) |
repository.mail.fl_str_mv |
pob@edu.usp.br||bor@sbpqo.org.br |
_version_ |
1750318324283080704 |