Biochemical evaluation of glycemic levels of long-term tacrolimus therapy in rats
Autor(a) principal: | |
---|---|
Data de Publicação: | 2007 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Oral Research |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242007000400002 |
Resumo: | One of the more serious complications following transplantation is the development of post-transplantation diabetes mellitus (PTDM), which has a major impact on the quality of life, with effects ranging from the control of glycemia times to increased susceptibility to infections and cardiovascular complications. It has been suggested that immunosuppressive therapy, mainly tacrolimus therapy, may be an important factor in the development of PTDM. There is a lack of studies that explore the effects of long-term tacrolimus on PTDM in animal protocols. The objective of this study was therefore to evaluate the effects of long-term therapy with tacrolimus in rats. One group was treated with tacrolimus, injected subcutaneously, in a daily dose of 1 mg/kg of body weight. The chosen dose was sufficient to achieve therapeutic tacrolimus serum levels. The experimental periods were 60, 120, 180 and 240 days. One group was used as control and received daily subcutaneous injections of saline solution during all periods. A tendency towards increased glycemia levels during the initial periods (60 and 120 days) was observed. However, at 180 and 240 days, the glycemia levels were not statistically different from that of the control group of the same period. It may thus be concluded that the deleterious effects of tacrolimus therapy on glycemia may be a time-related side effect. |
id |
SBPQO-1_31498205be3a9634b230b919d9e7eb1b |
---|---|
oai_identifier_str |
oai:scielo:S1806-83242007000400002 |
network_acronym_str |
SBPQO-1 |
network_name_str |
Brazilian Oral Research |
repository_id_str |
|
spelling |
Biochemical evaluation of glycemic levels of long-term tacrolimus therapy in ratsTacrolimus/adverse effectsGlycemic indexDiabetes mellitusRatsOne of the more serious complications following transplantation is the development of post-transplantation diabetes mellitus (PTDM), which has a major impact on the quality of life, with effects ranging from the control of glycemia times to increased susceptibility to infections and cardiovascular complications. It has been suggested that immunosuppressive therapy, mainly tacrolimus therapy, may be an important factor in the development of PTDM. There is a lack of studies that explore the effects of long-term tacrolimus on PTDM in animal protocols. The objective of this study was therefore to evaluate the effects of long-term therapy with tacrolimus in rats. One group was treated with tacrolimus, injected subcutaneously, in a daily dose of 1 mg/kg of body weight. The chosen dose was sufficient to achieve therapeutic tacrolimus serum levels. The experimental periods were 60, 120, 180 and 240 days. One group was used as control and received daily subcutaneous injections of saline solution during all periods. A tendency towards increased glycemia levels during the initial periods (60 and 120 days) was observed. However, at 180 and 240 days, the glycemia levels were not statistically different from that of the control group of the same period. It may thus be concluded that the deleterious effects of tacrolimus therapy on glycemia may be a time-related side effect.Sociedade Brasileira de Pesquisa Odontológica - SBPqO2007-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242007000400002Brazilian Oral Research v.21 n.4 2007reponame:Brazilian Oral Researchinstname:Sociedade Brasileira de Pesquisa Odontológica (SBPqO)instacron:SBPQO10.1590/S1806-83242007000400002info:eu-repo/semantics/openAccessNassar,Carlos AugustoNassar,Patricia OehlmeyerAndia,Denise CarletoGuimarães,Morgana RodriguesPepato,Maria TeresaSpolidorio,Luis Carloseng2009-10-19T00:00:00Zoai:scielo:S1806-83242007000400002Revistahttps://www.scielo.br/j/bor/https://old.scielo.br/oai/scielo-oai.phppob@edu.usp.br||bor@sbpqo.org.br1807-31071806-8324opendoar:2009-10-19T00:00Brazilian Oral Research - Sociedade Brasileira de Pesquisa Odontológica (SBPqO)false |
dc.title.none.fl_str_mv |
Biochemical evaluation of glycemic levels of long-term tacrolimus therapy in rats |
title |
Biochemical evaluation of glycemic levels of long-term tacrolimus therapy in rats |
spellingShingle |
Biochemical evaluation of glycemic levels of long-term tacrolimus therapy in rats Nassar,Carlos Augusto Tacrolimus/adverse effects Glycemic index Diabetes mellitus Rats |
title_short |
Biochemical evaluation of glycemic levels of long-term tacrolimus therapy in rats |
title_full |
Biochemical evaluation of glycemic levels of long-term tacrolimus therapy in rats |
title_fullStr |
Biochemical evaluation of glycemic levels of long-term tacrolimus therapy in rats |
title_full_unstemmed |
Biochemical evaluation of glycemic levels of long-term tacrolimus therapy in rats |
title_sort |
Biochemical evaluation of glycemic levels of long-term tacrolimus therapy in rats |
author |
Nassar,Carlos Augusto |
author_facet |
Nassar,Carlos Augusto Nassar,Patricia Oehlmeyer Andia,Denise Carleto Guimarães,Morgana Rodrigues Pepato,Maria Teresa Spolidorio,Luis Carlos |
author_role |
author |
author2 |
Nassar,Patricia Oehlmeyer Andia,Denise Carleto Guimarães,Morgana Rodrigues Pepato,Maria Teresa Spolidorio,Luis Carlos |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Nassar,Carlos Augusto Nassar,Patricia Oehlmeyer Andia,Denise Carleto Guimarães,Morgana Rodrigues Pepato,Maria Teresa Spolidorio,Luis Carlos |
dc.subject.por.fl_str_mv |
Tacrolimus/adverse effects Glycemic index Diabetes mellitus Rats |
topic |
Tacrolimus/adverse effects Glycemic index Diabetes mellitus Rats |
description |
One of the more serious complications following transplantation is the development of post-transplantation diabetes mellitus (PTDM), which has a major impact on the quality of life, with effects ranging from the control of glycemia times to increased susceptibility to infections and cardiovascular complications. It has been suggested that immunosuppressive therapy, mainly tacrolimus therapy, may be an important factor in the development of PTDM. There is a lack of studies that explore the effects of long-term tacrolimus on PTDM in animal protocols. The objective of this study was therefore to evaluate the effects of long-term therapy with tacrolimus in rats. One group was treated with tacrolimus, injected subcutaneously, in a daily dose of 1 mg/kg of body weight. The chosen dose was sufficient to achieve therapeutic tacrolimus serum levels. The experimental periods were 60, 120, 180 and 240 days. One group was used as control and received daily subcutaneous injections of saline solution during all periods. A tendency towards increased glycemia levels during the initial periods (60 and 120 days) was observed. However, at 180 and 240 days, the glycemia levels were not statistically different from that of the control group of the same period. It may thus be concluded that the deleterious effects of tacrolimus therapy on glycemia may be a time-related side effect. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242007000400002 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242007000400002 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1806-83242007000400002 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Pesquisa Odontológica - SBPqO |
publisher.none.fl_str_mv |
Sociedade Brasileira de Pesquisa Odontológica - SBPqO |
dc.source.none.fl_str_mv |
Brazilian Oral Research v.21 n.4 2007 reponame:Brazilian Oral Research instname:Sociedade Brasileira de Pesquisa Odontológica (SBPqO) instacron:SBPQO |
instname_str |
Sociedade Brasileira de Pesquisa Odontológica (SBPqO) |
instacron_str |
SBPQO |
institution |
SBPQO |
reponame_str |
Brazilian Oral Research |
collection |
Brazilian Oral Research |
repository.name.fl_str_mv |
Brazilian Oral Research - Sociedade Brasileira de Pesquisa Odontológica (SBPqO) |
repository.mail.fl_str_mv |
pob@edu.usp.br||bor@sbpqo.org.br |
_version_ |
1750318321186635776 |