Preliminary findings on the possible role of B-lymphocyte stimulator (BLyS) on diabetes-related periodontitis
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Oral Research |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242020000100228 |
Resumo: | Abstract The possible role of B-cell growth and differentiation-related cytokines on the pathogenesis of diabetes-related periodontitis has not been addressed so far. The aim of this study was to evaluate the effects of diabetes mellitus (DM) on the gene expression of proliferation-inducing ligand (APRIL) and B-lymphocyte stimulator (BLyS), two major cytokines associated to survival, differentiation and maturation of B cells in biopsies from gingival tissue with periodontitis. Gingival biopsies were obtained from subjects with periodontitis (n = 17), with periodontitis and DM (n = 19) as well as from periodontally and systemically healthy controls (n = 10). Gene expressions for APRIL, BLyS, RANKL, OPG, TRAP and DC-STAMP were evaluated using qPCR. The expressions APRIL, BLyS, RANKL, OPG, TRAP and DC-STAMP were all higher in both periodontitis groups when compared to the control group (p < 0.05). Furthermore, the expressions of BLyS, TRAP and RANKL were significantly higher in the subjects with periodontitis and DM when compared to those with periodontitis alone (p < 0.05). The mRNA levels of BLyS correlated positively with RANKL in the subjects with periodontitis and DM (p < 0.05). BLyS is overexpressed in periodontitis tissues of subjects with type 2 DM, suggesting a possible role of this cytokine on the pathogenesis DM-related periodontitis. |
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Preliminary findings on the possible role of B-lymphocyte stimulator (BLyS) on diabetes-related periodontitisPeriodontitisDiabetes MellitusInflammationCytokinesAbstract The possible role of B-cell growth and differentiation-related cytokines on the pathogenesis of diabetes-related periodontitis has not been addressed so far. The aim of this study was to evaluate the effects of diabetes mellitus (DM) on the gene expression of proliferation-inducing ligand (APRIL) and B-lymphocyte stimulator (BLyS), two major cytokines associated to survival, differentiation and maturation of B cells in biopsies from gingival tissue with periodontitis. Gingival biopsies were obtained from subjects with periodontitis (n = 17), with periodontitis and DM (n = 19) as well as from periodontally and systemically healthy controls (n = 10). Gene expressions for APRIL, BLyS, RANKL, OPG, TRAP and DC-STAMP were evaluated using qPCR. The expressions APRIL, BLyS, RANKL, OPG, TRAP and DC-STAMP were all higher in both periodontitis groups when compared to the control group (p < 0.05). Furthermore, the expressions of BLyS, TRAP and RANKL were significantly higher in the subjects with periodontitis and DM when compared to those with periodontitis alone (p < 0.05). The mRNA levels of BLyS correlated positively with RANKL in the subjects with periodontitis and DM (p < 0.05). BLyS is overexpressed in periodontitis tissues of subjects with type 2 DM, suggesting a possible role of this cytokine on the pathogenesis DM-related periodontitis.Sociedade Brasileira de Pesquisa Odontológica - SBPqO2020-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242020000100228Brazilian Oral Research v.34 2020reponame:Brazilian Oral Researchinstname:Sociedade Brasileira de Pesquisa Odontológica (SBPqO)instacron:SBPQO10.1590/1807-3107bor-2020.vol34.0038info:eu-repo/semantics/openAccessDRUMOND,Marx Haddley FerreiraPUHL,Luciano EduardoDUARTE,Poliana MendesMIRANDA,Tamires Szeremeske deCLEMENTE-NAPIMOGA,Juliana TrindadePERUZZO,Daiane CristinaMARTINEZ,Elizabeth FerreiraNAPIMOGA,Marcelo Henriqueeng2020-04-27T00:00:00Zoai:scielo:S1806-83242020000100228Revistahttps://www.scielo.br/j/bor/https://old.scielo.br/oai/scielo-oai.phppob@edu.usp.br||bor@sbpqo.org.br1807-31071806-8324opendoar:2020-04-27T00:00Brazilian Oral Research - Sociedade Brasileira de Pesquisa Odontológica (SBPqO)false |
dc.title.none.fl_str_mv |
Preliminary findings on the possible role of B-lymphocyte stimulator (BLyS) on diabetes-related periodontitis |
title |
Preliminary findings on the possible role of B-lymphocyte stimulator (BLyS) on diabetes-related periodontitis |
spellingShingle |
Preliminary findings on the possible role of B-lymphocyte stimulator (BLyS) on diabetes-related periodontitis DRUMOND,Marx Haddley Ferreira Periodontitis Diabetes Mellitus Inflammation Cytokines |
title_short |
Preliminary findings on the possible role of B-lymphocyte stimulator (BLyS) on diabetes-related periodontitis |
title_full |
Preliminary findings on the possible role of B-lymphocyte stimulator (BLyS) on diabetes-related periodontitis |
title_fullStr |
Preliminary findings on the possible role of B-lymphocyte stimulator (BLyS) on diabetes-related periodontitis |
title_full_unstemmed |
Preliminary findings on the possible role of B-lymphocyte stimulator (BLyS) on diabetes-related periodontitis |
title_sort |
Preliminary findings on the possible role of B-lymphocyte stimulator (BLyS) on diabetes-related periodontitis |
author |
DRUMOND,Marx Haddley Ferreira |
author_facet |
DRUMOND,Marx Haddley Ferreira PUHL,Luciano Eduardo DUARTE,Poliana Mendes MIRANDA,Tamires Szeremeske de CLEMENTE-NAPIMOGA,Juliana Trindade PERUZZO,Daiane Cristina MARTINEZ,Elizabeth Ferreira NAPIMOGA,Marcelo Henrique |
author_role |
author |
author2 |
PUHL,Luciano Eduardo DUARTE,Poliana Mendes MIRANDA,Tamires Szeremeske de CLEMENTE-NAPIMOGA,Juliana Trindade PERUZZO,Daiane Cristina MARTINEZ,Elizabeth Ferreira NAPIMOGA,Marcelo Henrique |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
DRUMOND,Marx Haddley Ferreira PUHL,Luciano Eduardo DUARTE,Poliana Mendes MIRANDA,Tamires Szeremeske de CLEMENTE-NAPIMOGA,Juliana Trindade PERUZZO,Daiane Cristina MARTINEZ,Elizabeth Ferreira NAPIMOGA,Marcelo Henrique |
dc.subject.por.fl_str_mv |
Periodontitis Diabetes Mellitus Inflammation Cytokines |
topic |
Periodontitis Diabetes Mellitus Inflammation Cytokines |
description |
Abstract The possible role of B-cell growth and differentiation-related cytokines on the pathogenesis of diabetes-related periodontitis has not been addressed so far. The aim of this study was to evaluate the effects of diabetes mellitus (DM) on the gene expression of proliferation-inducing ligand (APRIL) and B-lymphocyte stimulator (BLyS), two major cytokines associated to survival, differentiation and maturation of B cells in biopsies from gingival tissue with periodontitis. Gingival biopsies were obtained from subjects with periodontitis (n = 17), with periodontitis and DM (n = 19) as well as from periodontally and systemically healthy controls (n = 10). Gene expressions for APRIL, BLyS, RANKL, OPG, TRAP and DC-STAMP were evaluated using qPCR. The expressions APRIL, BLyS, RANKL, OPG, TRAP and DC-STAMP were all higher in both periodontitis groups when compared to the control group (p < 0.05). Furthermore, the expressions of BLyS, TRAP and RANKL were significantly higher in the subjects with periodontitis and DM when compared to those with periodontitis alone (p < 0.05). The mRNA levels of BLyS correlated positively with RANKL in the subjects with periodontitis and DM (p < 0.05). BLyS is overexpressed in periodontitis tissues of subjects with type 2 DM, suggesting a possible role of this cytokine on the pathogenesis DM-related periodontitis. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242020000100228 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242020000100228 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1807-3107bor-2020.vol34.0038 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Pesquisa Odontológica - SBPqO |
publisher.none.fl_str_mv |
Sociedade Brasileira de Pesquisa Odontológica - SBPqO |
dc.source.none.fl_str_mv |
Brazilian Oral Research v.34 2020 reponame:Brazilian Oral Research instname:Sociedade Brasileira de Pesquisa Odontológica (SBPqO) instacron:SBPQO |
instname_str |
Sociedade Brasileira de Pesquisa Odontológica (SBPqO) |
instacron_str |
SBPQO |
institution |
SBPQO |
reponame_str |
Brazilian Oral Research |
collection |
Brazilian Oral Research |
repository.name.fl_str_mv |
Brazilian Oral Research - Sociedade Brasileira de Pesquisa Odontológica (SBPqO) |
repository.mail.fl_str_mv |
pob@edu.usp.br||bor@sbpqo.org.br |
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1750318327056564224 |