Functionalized Dienes: A New Series of Potential Agents for the Treatment of Alzheimer’s Disease

Detalhes bibliográficos
Autor(a) principal: Oliveira,Aldo S.
Data de Publicação: 2019
Outros Autores: Meier,Lidiane, Zapp,Eduardo, Brondani,Daniela, Brighente,Inês M. C., Sá,Marcus M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532019000501045
Resumo: We report a series of functionalized dienes as compounds of great potential in the treatment of Alzheimer’s disease due to their antioxidant activity and ability to inhibit the enzyme acetylcholinesterase. The dienes tested showed high enzymatic inhibition capacity and accentuated antioxidant activity, which are comparable to or higher than the standards tested. Molecular docking studies were performed to confirm the experimental results. We also describe the correlation values between the antioxidant activity and oxidation potentials. Predicted bioactivity scores and quantum studies were also determined.
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spelling Functionalized Dienes: A New Series of Potential Agents for the Treatment of Alzheimer’s DiseasedienesantioxidantacetylcholinesteraseAlzheimer’s diseaseWe report a series of functionalized dienes as compounds of great potential in the treatment of Alzheimer’s disease due to their antioxidant activity and ability to inhibit the enzyme acetylcholinesterase. The dienes tested showed high enzymatic inhibition capacity and accentuated antioxidant activity, which are comparable to or higher than the standards tested. Molecular docking studies were performed to confirm the experimental results. We also describe the correlation values between the antioxidant activity and oxidation potentials. Predicted bioactivity scores and quantum studies were also determined.Sociedade Brasileira de Química2019-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532019000501045Journal of the Brazilian Chemical Society v.30 n.5 2019reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.21577/0103-5053.20190004info:eu-repo/semantics/openAccessOliveira,Aldo S.Meier,LidianeZapp,EduardoBrondani,DanielaBrighente,Inês M. C.Sá,Marcus M.eng2019-04-02T00:00:00Zoai:scielo:S0103-50532019000501045Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2019-04-02T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Functionalized Dienes: A New Series of Potential Agents for the Treatment of Alzheimer’s Disease
title Functionalized Dienes: A New Series of Potential Agents for the Treatment of Alzheimer’s Disease
spellingShingle Functionalized Dienes: A New Series of Potential Agents for the Treatment of Alzheimer’s Disease
Oliveira,Aldo S.
dienes
antioxidant
acetylcholinesterase
Alzheimer’s disease
title_short Functionalized Dienes: A New Series of Potential Agents for the Treatment of Alzheimer’s Disease
title_full Functionalized Dienes: A New Series of Potential Agents for the Treatment of Alzheimer’s Disease
title_fullStr Functionalized Dienes: A New Series of Potential Agents for the Treatment of Alzheimer’s Disease
title_full_unstemmed Functionalized Dienes: A New Series of Potential Agents for the Treatment of Alzheimer’s Disease
title_sort Functionalized Dienes: A New Series of Potential Agents for the Treatment of Alzheimer’s Disease
author Oliveira,Aldo S.
author_facet Oliveira,Aldo S.
Meier,Lidiane
Zapp,Eduardo
Brondani,Daniela
Brighente,Inês M. C.
Sá,Marcus M.
author_role author
author2 Meier,Lidiane
Zapp,Eduardo
Brondani,Daniela
Brighente,Inês M. C.
Sá,Marcus M.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Oliveira,Aldo S.
Meier,Lidiane
Zapp,Eduardo
Brondani,Daniela
Brighente,Inês M. C.
Sá,Marcus M.
dc.subject.por.fl_str_mv dienes
antioxidant
acetylcholinesterase
Alzheimer’s disease
topic dienes
antioxidant
acetylcholinesterase
Alzheimer’s disease
description We report a series of functionalized dienes as compounds of great potential in the treatment of Alzheimer’s disease due to their antioxidant activity and ability to inhibit the enzyme acetylcholinesterase. The dienes tested showed high enzymatic inhibition capacity and accentuated antioxidant activity, which are comparable to or higher than the standards tested. Molecular docking studies were performed to confirm the experimental results. We also describe the correlation values between the antioxidant activity and oxidation potentials. Predicted bioactivity scores and quantum studies were also determined.
publishDate 2019
dc.date.none.fl_str_mv 2019-05-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532019000501045
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532019000501045
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.21577/0103-5053.20190004
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.30 n.5 2019
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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