Aromatic Polyketides and Macrolides from Microsphaeropsis arundinis
Main Author: | |
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Publication Date: | 2020 |
Other Authors: | , , , |
Format: | Article |
Language: | eng |
Source: | Journal of the Brazilian Chemical Society (Online) |
Download full: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532020000200364 |
Summary: | The endophytic fungus Microsphaeropsis arundinis was isolated from the capitula of the tropical plant Paepalanthus planifolius (Eriocaulaceae). The fungus was cultivated in seven different media, and the ethyl acetate extracts were tested against tumor cell lines using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide MTT assay. The culture was scaled up using parboiled rice medium, and the crude extract was purified by classical chromatographic analyses, leading to the isolation of seven compounds. The seven compounds isolated from the culture media included a new aromatic polyketide (1) and other known metabolites. The structures of all the compounds were elucidated by 1D and 2D nuclear magnetic resonance (NMR) and high resolution mass spectrometry (HRMS) analyses. An evaluation of the cytotoxicity of all the isolated compounds showed that these compounds exhibit less activity in comparison with the extract cultured in parboiled rice. |
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Aromatic Polyketides and Macrolides from Microsphaeropsis arundinisaromatic polyketidesmacrolidesMicrosphaeropsis arundinisPaepalanthus planifoliusThe endophytic fungus Microsphaeropsis arundinis was isolated from the capitula of the tropical plant Paepalanthus planifolius (Eriocaulaceae). The fungus was cultivated in seven different media, and the ethyl acetate extracts were tested against tumor cell lines using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide MTT assay. The culture was scaled up using parboiled rice medium, and the crude extract was purified by classical chromatographic analyses, leading to the isolation of seven compounds. The seven compounds isolated from the culture media included a new aromatic polyketide (1) and other known metabolites. The structures of all the compounds were elucidated by 1D and 2D nuclear magnetic resonance (NMR) and high resolution mass spectrometry (HRMS) analyses. An evaluation of the cytotoxicity of all the isolated compounds showed that these compounds exhibit less activity in comparison with the extract cultured in parboiled rice.Sociedade Brasileira de Química2020-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532020000200364Journal of the Brazilian Chemical Society v.31 n.2 2020reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.21577/0103-5053.20190189info:eu-repo/semantics/openAccessBotero,Weslei BrunoAmorim,Marcelo R. deCarlos,Iracilda Z.Polesi,Marisa C.Santos,Lourdes C. doseng2020-01-17T00:00:00Zoai:scielo:S0103-50532020000200364Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2020-01-17T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
Aromatic Polyketides and Macrolides from Microsphaeropsis arundinis |
title |
Aromatic Polyketides and Macrolides from Microsphaeropsis arundinis |
spellingShingle |
Aromatic Polyketides and Macrolides from Microsphaeropsis arundinis Botero,Weslei Bruno aromatic polyketides macrolides Microsphaeropsis arundinis Paepalanthus planifolius |
title_short |
Aromatic Polyketides and Macrolides from Microsphaeropsis arundinis |
title_full |
Aromatic Polyketides and Macrolides from Microsphaeropsis arundinis |
title_fullStr |
Aromatic Polyketides and Macrolides from Microsphaeropsis arundinis |
title_full_unstemmed |
Aromatic Polyketides and Macrolides from Microsphaeropsis arundinis |
title_sort |
Aromatic Polyketides and Macrolides from Microsphaeropsis arundinis |
author |
Botero,Weslei Bruno |
author_facet |
Botero,Weslei Bruno Amorim,Marcelo R. de Carlos,Iracilda Z. Polesi,Marisa C. Santos,Lourdes C. dos |
author_role |
author |
author2 |
Amorim,Marcelo R. de Carlos,Iracilda Z. Polesi,Marisa C. Santos,Lourdes C. dos |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Botero,Weslei Bruno Amorim,Marcelo R. de Carlos,Iracilda Z. Polesi,Marisa C. Santos,Lourdes C. dos |
dc.subject.por.fl_str_mv |
aromatic polyketides macrolides Microsphaeropsis arundinis Paepalanthus planifolius |
topic |
aromatic polyketides macrolides Microsphaeropsis arundinis Paepalanthus planifolius |
description |
The endophytic fungus Microsphaeropsis arundinis was isolated from the capitula of the tropical plant Paepalanthus planifolius (Eriocaulaceae). The fungus was cultivated in seven different media, and the ethyl acetate extracts were tested against tumor cell lines using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide MTT assay. The culture was scaled up using parboiled rice medium, and the crude extract was purified by classical chromatographic analyses, leading to the isolation of seven compounds. The seven compounds isolated from the culture media included a new aromatic polyketide (1) and other known metabolites. The structures of all the compounds were elucidated by 1D and 2D nuclear magnetic resonance (NMR) and high resolution mass spectrometry (HRMS) analyses. An evaluation of the cytotoxicity of all the isolated compounds showed that these compounds exhibit less activity in comparison with the extract cultured in parboiled rice. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-02-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532020000200364 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532020000200364 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.21577/0103-5053.20190189 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Journal of the Brazilian Chemical Society v.31 n.2 2020 reponame:Journal of the Brazilian Chemical Society (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Journal of the Brazilian Chemical Society (Online) |
collection |
Journal of the Brazilian Chemical Society (Online) |
repository.name.fl_str_mv |
Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
||office@jbcs.sbq.org.br |
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1750318182616268800 |