(Bio)conjugation Strategies Applied to Fluorescent Semiconductor Quantum Dots
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of the Brazilian Chemical Society (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532019001202536 |
Resumo: | Quantum dots (QDs) are semiconductor nanocrystals, which present unique photophysical properties, enabling their application as new fluorescent platforms for biomedical sciences. Colloidal QDs are end-capped with organic or inorganic compounds, not only to prevent their agglomeration but also to provide reaction sites for the attachment of targeting (bio)molecules, nanoparticles or other interfaces, for specific biological purposes. The (bio)conjugation can involve non-covalent or covalent interactions, which can be accomplished through different strategies. The final assembly needs to maintain its chemical and optical stability and biochemical functionality. Although a relative good comprehension of the experimental procedures has been established, the bioconjugation process is still a challenge. The present manuscript aims to review the main (bio)conjugation strategies successfully applied to QDs, describing the steps necessary to prepare stable targeting fluorescent nanoplatforms, as well as some usual methods used to evaluate and optimize this process. |
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(Bio)conjugation Strategies Applied to Fluorescent Semiconductor Quantum Dotsnanocrystalsfluorescencecross-linkersconjugation strategiesQuantum dots (QDs) are semiconductor nanocrystals, which present unique photophysical properties, enabling their application as new fluorescent platforms for biomedical sciences. Colloidal QDs are end-capped with organic or inorganic compounds, not only to prevent their agglomeration but also to provide reaction sites for the attachment of targeting (bio)molecules, nanoparticles or other interfaces, for specific biological purposes. The (bio)conjugation can involve non-covalent or covalent interactions, which can be accomplished through different strategies. The final assembly needs to maintain its chemical and optical stability and biochemical functionality. Although a relative good comprehension of the experimental procedures has been established, the bioconjugation process is still a challenge. The present manuscript aims to review the main (bio)conjugation strategies successfully applied to QDs, describing the steps necessary to prepare stable targeting fluorescent nanoplatforms, as well as some usual methods used to evaluate and optimize this process.Sociedade Brasileira de Química2019-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532019001202536Journal of the Brazilian Chemical Society v.30 n.12 2019reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.21577/0103-5053.20190163info:eu-repo/semantics/openAccessPereira,GoretiMonteiro,Camila A. P.Albuquerque,Gabriela M.Pereira,Maria I. A.Cabrera,Mariana P.Cabral Filho,Paulo E.Pereira,Giovannia A. L.Fontesa,AdrianaSantos,Beate S.eng2019-10-21T00:00:00Zoai:scielo:S0103-50532019001202536Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2019-10-21T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
(Bio)conjugation Strategies Applied to Fluorescent Semiconductor Quantum Dots |
title |
(Bio)conjugation Strategies Applied to Fluorescent Semiconductor Quantum Dots |
spellingShingle |
(Bio)conjugation Strategies Applied to Fluorescent Semiconductor Quantum Dots Pereira,Goreti nanocrystals fluorescence cross-linkers conjugation strategies |
title_short |
(Bio)conjugation Strategies Applied to Fluorescent Semiconductor Quantum Dots |
title_full |
(Bio)conjugation Strategies Applied to Fluorescent Semiconductor Quantum Dots |
title_fullStr |
(Bio)conjugation Strategies Applied to Fluorescent Semiconductor Quantum Dots |
title_full_unstemmed |
(Bio)conjugation Strategies Applied to Fluorescent Semiconductor Quantum Dots |
title_sort |
(Bio)conjugation Strategies Applied to Fluorescent Semiconductor Quantum Dots |
author |
Pereira,Goreti |
author_facet |
Pereira,Goreti Monteiro,Camila A. P. Albuquerque,Gabriela M. Pereira,Maria I. A. Cabrera,Mariana P. Cabral Filho,Paulo E. Pereira,Giovannia A. L. Fontesa,Adriana Santos,Beate S. |
author_role |
author |
author2 |
Monteiro,Camila A. P. Albuquerque,Gabriela M. Pereira,Maria I. A. Cabrera,Mariana P. Cabral Filho,Paulo E. Pereira,Giovannia A. L. Fontesa,Adriana Santos,Beate S. |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Pereira,Goreti Monteiro,Camila A. P. Albuquerque,Gabriela M. Pereira,Maria I. A. Cabrera,Mariana P. Cabral Filho,Paulo E. Pereira,Giovannia A. L. Fontesa,Adriana Santos,Beate S. |
dc.subject.por.fl_str_mv |
nanocrystals fluorescence cross-linkers conjugation strategies |
topic |
nanocrystals fluorescence cross-linkers conjugation strategies |
description |
Quantum dots (QDs) are semiconductor nanocrystals, which present unique photophysical properties, enabling their application as new fluorescent platforms for biomedical sciences. Colloidal QDs are end-capped with organic or inorganic compounds, not only to prevent their agglomeration but also to provide reaction sites for the attachment of targeting (bio)molecules, nanoparticles or other interfaces, for specific biological purposes. The (bio)conjugation can involve non-covalent or covalent interactions, which can be accomplished through different strategies. The final assembly needs to maintain its chemical and optical stability and biochemical functionality. Although a relative good comprehension of the experimental procedures has been established, the bioconjugation process is still a challenge. The present manuscript aims to review the main (bio)conjugation strategies successfully applied to QDs, describing the steps necessary to prepare stable targeting fluorescent nanoplatforms, as well as some usual methods used to evaluate and optimize this process. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532019001202536 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532019001202536 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.21577/0103-5053.20190163 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Journal of the Brazilian Chemical Society v.30 n.12 2019 reponame:Journal of the Brazilian Chemical Society (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Journal of the Brazilian Chemical Society (Online) |
collection |
Journal of the Brazilian Chemical Society (Online) |
repository.name.fl_str_mv |
Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
||office@jbcs.sbq.org.br |
_version_ |
1750318182496731136 |