Alkaloids from Annona dioica

• Autor(a) principal: Santos,Paulo R. D. dos
• Data de Publicação: 2003
• Outros Autores: Morais,Anselmo A., Braz-Filho,Raimundo
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Journal of the Brazilian Chemical Society (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532003000300009
• topic: Annona dioica; Annonaceae; quinoline alkaloids; lignoaporphine; lasiodiplodin

From the ethanolic extract of the wood of Annona dioica were isolated the known 1-aza-4-methylanthraquinone, lasiodiplodin, liriodenine, a mixture of 1-aza-5,9,10-trimethoxy-4-methyl-2-oxo-1,2-dihydroanthracene and 1-aza-8,9,10-trimethoxy-4-methyl-2-oxo-1,2-dihydroanthracene (geovanine) and the new alkaloid 1,2-methylenedioxy-6alpha,7-dehydroaporphine-4(S )-(4-hydroxy-3,5-dimethoxyphenyl)-3,4-dihydro-2(1H)-pyridinone. The structures of these natural products were elucidated on the basis of their spectral data, including NOE experiments and homonuclear ¹H-¹H-COSY e heteronuclear ¹H-13C-COSY-nJ CH (HMQC, n=1 and HMBC, n=2 and 3) 2D-shift-correlated NMR spectra.