Synthesis and characterization of platinum(II) complexes from trifluoromethyl phenylenediamine, picoline and N-benzyl ethylenediamine derivatives

Detalhes bibliográficos
Autor(a) principal: Almeida,Mauro V. de
Data de Publicação: 2006
Outros Autores: Chaves,Joana Darc S., Fontes,Ana Paula Soares, César,Eloi T., Gielen,Marcel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532006000700011
Resumo: This work describes the synthesis and characterization of eleven new platinum(II) complexes having ligands derived from 1,2-phenylenediamine, N-benzyl ethylenediamine and 2- or 4-picoline. The complexes were prepared in satisfactory yields by reaction of K2[PtCl4] with the appropriate ligand. The cytotoxic pre-screening of one of these complexes in seven human cancer cell lines showed that this compound is much less active than cisplatin.
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spelling Synthesis and characterization of platinum(II) complexes from trifluoromethyl phenylenediamine, picoline and N-benzyl ethylenediamine derivativesplatinum(II) complexes1,2-phenylenediamineN-benzyl ethylenediaminepicolinecancerThis work describes the synthesis and characterization of eleven new platinum(II) complexes having ligands derived from 1,2-phenylenediamine, N-benzyl ethylenediamine and 2- or 4-picoline. The complexes were prepared in satisfactory yields by reaction of K2[PtCl4] with the appropriate ligand. The cytotoxic pre-screening of one of these complexes in seven human cancer cell lines showed that this compound is much less active than cisplatin.Sociedade Brasileira de Química2006-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532006000700011Journal of the Brazilian Chemical Society v.17 n.7 2006reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532006000700011info:eu-repo/semantics/openAccessAlmeida,Mauro V. deChaves,Joana Darc S.Fontes,Ana Paula SoaresCésar,Eloi T.Gielen,Marceleng2007-01-29T00:00:00Zoai:scielo:S0103-50532006000700011Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2007-01-29T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Synthesis and characterization of platinum(II) complexes from trifluoromethyl phenylenediamine, picoline and N-benzyl ethylenediamine derivatives
title Synthesis and characterization of platinum(II) complexes from trifluoromethyl phenylenediamine, picoline and N-benzyl ethylenediamine derivatives
spellingShingle Synthesis and characterization of platinum(II) complexes from trifluoromethyl phenylenediamine, picoline and N-benzyl ethylenediamine derivatives
Almeida,Mauro V. de
platinum(II) complexes
1,2-phenylenediamine
N-benzyl ethylenediamine
picoline
cancer
title_short Synthesis and characterization of platinum(II) complexes from trifluoromethyl phenylenediamine, picoline and N-benzyl ethylenediamine derivatives
title_full Synthesis and characterization of platinum(II) complexes from trifluoromethyl phenylenediamine, picoline and N-benzyl ethylenediamine derivatives
title_fullStr Synthesis and characterization of platinum(II) complexes from trifluoromethyl phenylenediamine, picoline and N-benzyl ethylenediamine derivatives
title_full_unstemmed Synthesis and characterization of platinum(II) complexes from trifluoromethyl phenylenediamine, picoline and N-benzyl ethylenediamine derivatives
title_sort Synthesis and characterization of platinum(II) complexes from trifluoromethyl phenylenediamine, picoline and N-benzyl ethylenediamine derivatives
author Almeida,Mauro V. de
author_facet Almeida,Mauro V. de
Chaves,Joana Darc S.
Fontes,Ana Paula Soares
César,Eloi T.
Gielen,Marcel
author_role author
author2 Chaves,Joana Darc S.
Fontes,Ana Paula Soares
César,Eloi T.
Gielen,Marcel
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Almeida,Mauro V. de
Chaves,Joana Darc S.
Fontes,Ana Paula Soares
César,Eloi T.
Gielen,Marcel
dc.subject.por.fl_str_mv platinum(II) complexes
1,2-phenylenediamine
N-benzyl ethylenediamine
picoline
cancer
topic platinum(II) complexes
1,2-phenylenediamine
N-benzyl ethylenediamine
picoline
cancer
description This work describes the synthesis and characterization of eleven new platinum(II) complexes having ligands derived from 1,2-phenylenediamine, N-benzyl ethylenediamine and 2- or 4-picoline. The complexes were prepared in satisfactory yields by reaction of K2[PtCl4] with the appropriate ligand. The cytotoxic pre-screening of one of these complexes in seven human cancer cell lines showed that this compound is much less active than cisplatin.
publishDate 2006
dc.date.none.fl_str_mv 2006-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532006000700011
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532006000700011
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-50532006000700011
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.17 n.7 2006
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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