Synthesis and biological activity of novel statine derivatives containing ferrocenyl moiety

Detalhes bibliográficos
Autor(a) principal: Gu,Lijun
Data de Publicação: 2010
Outros Autores: Yang,Bingqin, Liu,Feilong
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532010000100010
Resumo: In a search for new aspartic protease inhibitors, conjugates of ferrocene with statine were designed and synthesized by coupling reaction using the standard N,N'-dicyclohexylcarbodiimide (DCC) and 1-hydroxybenzotriazole (HOBt) protocol. The title compounds were characterized by IR, ¹H NMR spectroscopy, MS and elemental analysis. The results of bioassay showed that some title compounds could serve as a starting point.
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spelling Synthesis and biological activity of novel statine derivatives containing ferrocenyl moietystatineferroceneaspartic proteasesynthesisbiological activityIn a search for new aspartic protease inhibitors, conjugates of ferrocene with statine were designed and synthesized by coupling reaction using the standard N,N'-dicyclohexylcarbodiimide (DCC) and 1-hydroxybenzotriazole (HOBt) protocol. The title compounds were characterized by IR, ¹H NMR spectroscopy, MS and elemental analysis. The results of bioassay showed that some title compounds could serve as a starting point.Sociedade Brasileira de Química2010-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532010000100010Journal of the Brazilian Chemical Society v.21 n.1 2010reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532010000100010info:eu-repo/semantics/openAccessGu,LijunYang,BingqinLiu,Feilongeng2010-02-18T00:00:00Zoai:scielo:S0103-50532010000100010Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2010-02-18T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Synthesis and biological activity of novel statine derivatives containing ferrocenyl moiety
title Synthesis and biological activity of novel statine derivatives containing ferrocenyl moiety
spellingShingle Synthesis and biological activity of novel statine derivatives containing ferrocenyl moiety
Gu,Lijun
statine
ferrocene
aspartic protease
synthesis
biological activity
title_short Synthesis and biological activity of novel statine derivatives containing ferrocenyl moiety
title_full Synthesis and biological activity of novel statine derivatives containing ferrocenyl moiety
title_fullStr Synthesis and biological activity of novel statine derivatives containing ferrocenyl moiety
title_full_unstemmed Synthesis and biological activity of novel statine derivatives containing ferrocenyl moiety
title_sort Synthesis and biological activity of novel statine derivatives containing ferrocenyl moiety
author Gu,Lijun
author_facet Gu,Lijun
Yang,Bingqin
Liu,Feilong
author_role author
author2 Yang,Bingqin
Liu,Feilong
author2_role author
author
dc.contributor.author.fl_str_mv Gu,Lijun
Yang,Bingqin
Liu,Feilong
dc.subject.por.fl_str_mv statine
ferrocene
aspartic protease
synthesis
biological activity
topic statine
ferrocene
aspartic protease
synthesis
biological activity
description In a search for new aspartic protease inhibitors, conjugates of ferrocene with statine were designed and synthesized by coupling reaction using the standard N,N'-dicyclohexylcarbodiimide (DCC) and 1-hydroxybenzotriazole (HOBt) protocol. The title compounds were characterized by IR, ¹H NMR spectroscopy, MS and elemental analysis. The results of bioassay showed that some title compounds could serve as a starting point.
publishDate 2010
dc.date.none.fl_str_mv 2010-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532010000100010
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532010000100010
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-50532010000100010
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.21 n.1 2010
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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