Selective and efficient mitochondrial staining with designed 2,1,3-benzothiadiazole derivatives as live cell fluorescence imaging probes

Detalhes bibliográficos
Autor(a) principal: D. Neto,Brenno A.
Data de Publicação: 2012
Outros Autores: Corrêa,José R., Carvalho,Pedro H. P. R., Santos,Diego C. B. D., Guido,Bruna C., Gatto,Claudia C., Oliveira,Heibbe C. B. de, Fasciotti,Maíra, Eberlin,Marcos N, Silva Jr.,Eufrânio N. da
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532012000400024
Resumo: Novel designed 2,1,3-benzothiadiazole fluorescent probes were synthesized, characterized and applied as live cell fluorescence imaging probe staining only mitochondria in mammalian cancer cell lines (MCF-7). The efficiency of these new probes was found to be much superior to that of the commercially available MitoTracker® Red. Cellular and in vitro experiments allowed better understanding of the relationship between the planned molecular architecture of the new dyes and the observed cellular selectivity.
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spelling Selective and efficient mitochondrial staining with designed 2,1,3-benzothiadiazole derivatives as live cell fluorescence imaging probesbenzothiadiazolesynthesismitochondriacellular stainingNovel designed 2,1,3-benzothiadiazole fluorescent probes were synthesized, characterized and applied as live cell fluorescence imaging probe staining only mitochondria in mammalian cancer cell lines (MCF-7). The efficiency of these new probes was found to be much superior to that of the commercially available MitoTracker® Red. Cellular and in vitro experiments allowed better understanding of the relationship between the planned molecular architecture of the new dyes and the observed cellular selectivity.Sociedade Brasileira de Química2012-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532012000400024Journal of the Brazilian Chemical Society v.23 n.4 2012reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532012000400024info:eu-repo/semantics/openAccessD. Neto,Brenno A.Corrêa,José R.Carvalho,Pedro H. P. R.Santos,Diego C. B. D.Guido,Bruna C.Gatto,Claudia C.Oliveira,Heibbe C. B. deFasciotti,MaíraEberlin,Marcos NSilva Jr.,Eufrânio N. daeng2012-04-27T00:00:00Zoai:scielo:S0103-50532012000400024Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2012-04-27T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Selective and efficient mitochondrial staining with designed 2,1,3-benzothiadiazole derivatives as live cell fluorescence imaging probes
title Selective and efficient mitochondrial staining with designed 2,1,3-benzothiadiazole derivatives as live cell fluorescence imaging probes
spellingShingle Selective and efficient mitochondrial staining with designed 2,1,3-benzothiadiazole derivatives as live cell fluorescence imaging probes
D. Neto,Brenno A.
benzothiadiazole
synthesis
mitochondria
cellular staining
title_short Selective and efficient mitochondrial staining with designed 2,1,3-benzothiadiazole derivatives as live cell fluorescence imaging probes
title_full Selective and efficient mitochondrial staining with designed 2,1,3-benzothiadiazole derivatives as live cell fluorescence imaging probes
title_fullStr Selective and efficient mitochondrial staining with designed 2,1,3-benzothiadiazole derivatives as live cell fluorescence imaging probes
title_full_unstemmed Selective and efficient mitochondrial staining with designed 2,1,3-benzothiadiazole derivatives as live cell fluorescence imaging probes
title_sort Selective and efficient mitochondrial staining with designed 2,1,3-benzothiadiazole derivatives as live cell fluorescence imaging probes
author D. Neto,Brenno A.
author_facet D. Neto,Brenno A.
Corrêa,José R.
Carvalho,Pedro H. P. R.
Santos,Diego C. B. D.
Guido,Bruna C.
Gatto,Claudia C.
Oliveira,Heibbe C. B. de
Fasciotti,Maíra
Eberlin,Marcos N
Silva Jr.,Eufrânio N. da
author_role author
author2 Corrêa,José R.
Carvalho,Pedro H. P. R.
Santos,Diego C. B. D.
Guido,Bruna C.
Gatto,Claudia C.
Oliveira,Heibbe C. B. de
Fasciotti,Maíra
Eberlin,Marcos N
Silva Jr.,Eufrânio N. da
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv D. Neto,Brenno A.
Corrêa,José R.
Carvalho,Pedro H. P. R.
Santos,Diego C. B. D.
Guido,Bruna C.
Gatto,Claudia C.
Oliveira,Heibbe C. B. de
Fasciotti,Maíra
Eberlin,Marcos N
Silva Jr.,Eufrânio N. da
dc.subject.por.fl_str_mv benzothiadiazole
synthesis
mitochondria
cellular staining
topic benzothiadiazole
synthesis
mitochondria
cellular staining
description Novel designed 2,1,3-benzothiadiazole fluorescent probes were synthesized, characterized and applied as live cell fluorescence imaging probe staining only mitochondria in mammalian cancer cell lines (MCF-7). The efficiency of these new probes was found to be much superior to that of the commercially available MitoTracker® Red. Cellular and in vitro experiments allowed better understanding of the relationship between the planned molecular architecture of the new dyes and the observed cellular selectivity.
publishDate 2012
dc.date.none.fl_str_mv 2012-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532012000400024
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532012000400024
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-50532012000400024
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.23 n.4 2012
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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