Leishmanicidal galloylquinic acids are noncompetitive inhibitors of arginase

• Autor(a) principal: Sousa,Lorena R. F. de
• Data de Publicação: 2014
• Outros Autores: Ramalho,Suelem D., Fernandes,João B., Silva,Maria Fátima das G. F. da, Iemma,Mônica R. da C., Corrêa,Caroindes J., Souza,Dulce H. F. de, Lima,Maria I. S., Vieira,Paulo C.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Journal of the Brazilian Chemical Society (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532014001000008
• topic: arginase; Leishmania; galloylquinic acids; Byrsonima coccolobifolia

Leishmanicidal galloylquinic acids were isolated from the ethyl acetate extract of Byrsonima coccolobifolia. These phenols and gallic acid showed to be a new class of potent noncompetitive inhibitors of arginase ARG (Ki ranging from 0.10 to 0.68 µmol L-1) from Leishmania amazonensis. Quinic acid did not exhibit significant inhibition of ARG, indicating that galloyl moiety has important features that allows the enzyme-inhibitor interactions. The significant inhibitory activity of gallic acid on ARG can be a clue to understand the immune response previously observed on L. donovani, since ARG activity is associated with the decrease of the levels of NO in Leishmania infection.