Quantitative reflectance spot test for the determination of acetylsalicylic acid in pharmaceutical preparations
Autor(a) principal: | |
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Data de Publicação: | 2004 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of the Brazilian Chemical Society (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532004000200027 |
Resumo: | This paper describes a quantitative reflectance spot test procedure for the determination of acetylsalicylic acid (ASA) in pharmaceutical preparations. The method is based on the reaction of salicylic acid, obtained from the hydrolysis of ASA, with Fe(III) forming a deep blue-violet compound. Medicines containing ASA can be easily analyzed by the proposed method as it is not necessary to do any separation. The final mixture is placed on a sheet of filter paper, and the reflectance is directly measured. Nine commercial medicines containing acetylsalicylic acid were analyzed with the proposed method. The mean RSD was 0.9%. Results were compared with those obtained with the United States Pharmacopoeia recommended procedure (RSD 0.6%). The quantitative detection limit is 0.6 mg ASA in the working solution. For a degree of freedom n = 4 (n = n1+ n2 - 2) and a confidence coefficient a = 0.05 all the results agree under the tabulated t-Student test value (2.78). |
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Quantitative reflectance spot test for the determination of acetylsalicylic acid in pharmaceutical preparationsacetylsalicylic acidspot testquantitative analysisreflectancepharmaceutical preparationsThis paper describes a quantitative reflectance spot test procedure for the determination of acetylsalicylic acid (ASA) in pharmaceutical preparations. The method is based on the reaction of salicylic acid, obtained from the hydrolysis of ASA, with Fe(III) forming a deep blue-violet compound. Medicines containing ASA can be easily analyzed by the proposed method as it is not necessary to do any separation. The final mixture is placed on a sheet of filter paper, and the reflectance is directly measured. Nine commercial medicines containing acetylsalicylic acid were analyzed with the proposed method. The mean RSD was 0.9%. Results were compared with those obtained with the United States Pharmacopoeia recommended procedure (RSD 0.6%). The quantitative detection limit is 0.6 mg ASA in the working solution. For a degree of freedom n = 4 (n = n1+ n2 - 2) and a confidence coefficient a = 0.05 all the results agree under the tabulated t-Student test value (2.78).Sociedade Brasileira de Química2004-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532004000200027Journal of the Brazilian Chemical Society v.15 n.2 2004reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532004000200027info:eu-repo/semantics/openAccessMatias,Francisco A. A.Vila,Marta M. D. C.Tubino,Matthieueng2004-06-29T00:00:00Zoai:scielo:S0103-50532004000200027Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2004-06-29T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
Quantitative reflectance spot test for the determination of acetylsalicylic acid in pharmaceutical preparations |
title |
Quantitative reflectance spot test for the determination of acetylsalicylic acid in pharmaceutical preparations |
spellingShingle |
Quantitative reflectance spot test for the determination of acetylsalicylic acid in pharmaceutical preparations Matias,Francisco A. A. acetylsalicylic acid spot test quantitative analysis reflectance pharmaceutical preparations |
title_short |
Quantitative reflectance spot test for the determination of acetylsalicylic acid in pharmaceutical preparations |
title_full |
Quantitative reflectance spot test for the determination of acetylsalicylic acid in pharmaceutical preparations |
title_fullStr |
Quantitative reflectance spot test for the determination of acetylsalicylic acid in pharmaceutical preparations |
title_full_unstemmed |
Quantitative reflectance spot test for the determination of acetylsalicylic acid in pharmaceutical preparations |
title_sort |
Quantitative reflectance spot test for the determination of acetylsalicylic acid in pharmaceutical preparations |
author |
Matias,Francisco A. A. |
author_facet |
Matias,Francisco A. A. Vila,Marta M. D. C. Tubino,Matthieu |
author_role |
author |
author2 |
Vila,Marta M. D. C. Tubino,Matthieu |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Matias,Francisco A. A. Vila,Marta M. D. C. Tubino,Matthieu |
dc.subject.por.fl_str_mv |
acetylsalicylic acid spot test quantitative analysis reflectance pharmaceutical preparations |
topic |
acetylsalicylic acid spot test quantitative analysis reflectance pharmaceutical preparations |
description |
This paper describes a quantitative reflectance spot test procedure for the determination of acetylsalicylic acid (ASA) in pharmaceutical preparations. The method is based on the reaction of salicylic acid, obtained from the hydrolysis of ASA, with Fe(III) forming a deep blue-violet compound. Medicines containing ASA can be easily analyzed by the proposed method as it is not necessary to do any separation. The final mixture is placed on a sheet of filter paper, and the reflectance is directly measured. Nine commercial medicines containing acetylsalicylic acid were analyzed with the proposed method. The mean RSD was 0.9%. Results were compared with those obtained with the United States Pharmacopoeia recommended procedure (RSD 0.6%). The quantitative detection limit is 0.6 mg ASA in the working solution. For a degree of freedom n = 4 (n = n1+ n2 - 2) and a confidence coefficient a = 0.05 all the results agree under the tabulated t-Student test value (2.78). |
publishDate |
2004 |
dc.date.none.fl_str_mv |
2004-04-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532004000200027 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532004000200027 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0103-50532004000200027 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Journal of the Brazilian Chemical Society v.15 n.2 2004 reponame:Journal of the Brazilian Chemical Society (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Journal of the Brazilian Chemical Society (Online) |
collection |
Journal of the Brazilian Chemical Society (Online) |
repository.name.fl_str_mv |
Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
||office@jbcs.sbq.org.br |
_version_ |
1750318165728952320 |