Development of nanocapsule suspensions and nanocapsule spray-dried powders containing melatonin
Autor(a) principal: | |
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Data de Publicação: | 2006 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of the Brazilian Chemical Society (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532006000300020 |
Resumo: | Nanocapsule suspensions containing melatonin were prepared by interfacial deposition method and characterized (size, morphological aspect and encapsulation efficiency). The formulation parameters studied were the oil nature, the type of surfactants and the type of polymer. The melatonin-encapsulation efficiency ranged between 30% and 56% and polymer nature was the parameter that more influenced the characteristics of suspensions. According to the highest encapsulation efficiency, the nanocapsules prepared with Eudragit S100® were selected to be spray-dried in order to improve the physical stability of suspension and to control the release of melatonin. The melatonin-loaded nanocapsule spray-dried powder presented encapsulation efficiency of the 93% and no morphological alterations were observed after 12 months of storage. This system showed a controlled release profile in comparison to the dissolution of the pure melatonin. The release profile was fitted to monoexponential model and the melatonin release mechanism was based on swelling and dissolution of the polymer. |
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Journal of the Brazilian Chemical Society (Online) |
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Development of nanocapsule suspensions and nanocapsule spray-dried powders containing melatoninmelatoninnanocapsulesnanoparticlesspray-dried powdersNanocapsule suspensions containing melatonin were prepared by interfacial deposition method and characterized (size, morphological aspect and encapsulation efficiency). The formulation parameters studied were the oil nature, the type of surfactants and the type of polymer. The melatonin-encapsulation efficiency ranged between 30% and 56% and polymer nature was the parameter that more influenced the characteristics of suspensions. According to the highest encapsulation efficiency, the nanocapsules prepared with Eudragit S100® were selected to be spray-dried in order to improve the physical stability of suspension and to control the release of melatonin. The melatonin-loaded nanocapsule spray-dried powder presented encapsulation efficiency of the 93% and no morphological alterations were observed after 12 months of storage. This system showed a controlled release profile in comparison to the dissolution of the pure melatonin. The release profile was fitted to monoexponential model and the melatonin release mechanism was based on swelling and dissolution of the polymer.Sociedade Brasileira de Química2006-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532006000300020Journal of the Brazilian Chemical Society v.17 n.3 2006reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532006000300020info:eu-repo/semantics/openAccessSchaffazick,Scheila R.Pohlmann,Adriana R.Mezzalira,GrazielaGuterres,Sílvia S.eng2006-05-25T00:00:00Zoai:scielo:S0103-50532006000300020Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2006-05-25T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
Development of nanocapsule suspensions and nanocapsule spray-dried powders containing melatonin |
title |
Development of nanocapsule suspensions and nanocapsule spray-dried powders containing melatonin |
spellingShingle |
Development of nanocapsule suspensions and nanocapsule spray-dried powders containing melatonin Schaffazick,Scheila R. melatonin nanocapsules nanoparticles spray-dried powders |
title_short |
Development of nanocapsule suspensions and nanocapsule spray-dried powders containing melatonin |
title_full |
Development of nanocapsule suspensions and nanocapsule spray-dried powders containing melatonin |
title_fullStr |
Development of nanocapsule suspensions and nanocapsule spray-dried powders containing melatonin |
title_full_unstemmed |
Development of nanocapsule suspensions and nanocapsule spray-dried powders containing melatonin |
title_sort |
Development of nanocapsule suspensions and nanocapsule spray-dried powders containing melatonin |
author |
Schaffazick,Scheila R. |
author_facet |
Schaffazick,Scheila R. Pohlmann,Adriana R. Mezzalira,Graziela Guterres,Sílvia S. |
author_role |
author |
author2 |
Pohlmann,Adriana R. Mezzalira,Graziela Guterres,Sílvia S. |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Schaffazick,Scheila R. Pohlmann,Adriana R. Mezzalira,Graziela Guterres,Sílvia S. |
dc.subject.por.fl_str_mv |
melatonin nanocapsules nanoparticles spray-dried powders |
topic |
melatonin nanocapsules nanoparticles spray-dried powders |
description |
Nanocapsule suspensions containing melatonin were prepared by interfacial deposition method and characterized (size, morphological aspect and encapsulation efficiency). The formulation parameters studied were the oil nature, the type of surfactants and the type of polymer. The melatonin-encapsulation efficiency ranged between 30% and 56% and polymer nature was the parameter that more influenced the characteristics of suspensions. According to the highest encapsulation efficiency, the nanocapsules prepared with Eudragit S100® were selected to be spray-dried in order to improve the physical stability of suspension and to control the release of melatonin. The melatonin-loaded nanocapsule spray-dried powder presented encapsulation efficiency of the 93% and no morphological alterations were observed after 12 months of storage. This system showed a controlled release profile in comparison to the dissolution of the pure melatonin. The release profile was fitted to monoexponential model and the melatonin release mechanism was based on swelling and dissolution of the polymer. |
publishDate |
2006 |
dc.date.none.fl_str_mv |
2006-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532006000300020 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532006000300020 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0103-50532006000300020 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Journal of the Brazilian Chemical Society v.17 n.3 2006 reponame:Journal of the Brazilian Chemical Society (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Journal of the Brazilian Chemical Society (Online) |
collection |
Journal of the Brazilian Chemical Society (Online) |
repository.name.fl_str_mv |
Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
||office@jbcs.sbq.org.br |
_version_ |
1750318167029186560 |