Seleno- and Telluro-Functionalization of Quinones: Molecules with Relevant Biological Application

• Autor(a) principal: Cordeiro,Pâmella S.
• Data de Publicação: 2022
• Outros Autores: Chipoline,Ingrid C., Ribeiro,Ruan C. B., Pinho,David R., Ferreira,Vitor F., Silva,Fernando C. da, Forezi,Luana S. M., Nascimento,Vanessa
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Journal of the Brazilian Chemical Society (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532022000200111
• topic: selenides; tellurides; naphthoquinones; organochalcogens; biological activity

Quinones and organochalcogens are classes of compounds with great biological applicability, such as antioxidant, anticancer, anti-Alzheimer, and antidepressant activities, among others. Thus, the combination of these two classes of compounds is important to obtain new hits with biological activities that are additive or synergistic. Several methodologies for the preparation of this class of hybrid compound have been widely described. Many of the prepared hybrid molecules have shown increased biological activities and, in some cases, to act as two distinct pharmacophores. In this review, methods for the preparation of selenium-quinones, tellurium-quinones and their biological applications are highlighted.