Detalhes bibliográficos
| Autor(a) principal: |
Maia,Pedro I. da S. |
| Data de Publicação: |
2010 |
| Outros Autores: |
Graminha,Angélica,
Pavan,Fernando R.,
Leite,Clarice Q. F.,
Batista,Alzir A.,
Back,Davi F.,
Lang,Ernesto S.,
Ellena,Javier,
Lemos,Sebastião de S.,
Salistre-de-Araujo,Heloisa S.,
Deflon,Victor M. |
| Tipo de documento: |
Artigo
|
| Idioma: |
eng |
| Título da fonte: |
Journal of the Brazilian Chemical Society (Online) |
| Texto Completo: |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532010000700004
|
Resumo: |
Three PdII complexes were prepared from N(4)-substituted thiosemicarbazones: [Pd(aptsc)(PPh3)](NO3)H2O, 1, [Pd(apmtsc)(PPh3)](NO3), 2, and [Pd(apptsc)(PPh3)](NO3)H2O, 3, where PPh3 = triphenylphosphine; Haptsc = 2-acetylpyridine-thiosemicarbazone; Hapmtsc = 2-acetylpyridine-N(4)-methyl-thiosemicarbazone and Happtsc = 2-acetylpyridine-N(4)-phenyl-thiosemicarbazone. All complexes were characterized by elemental analysis, IR, UV-Vis, ¹H and 31P{¹H} NMR spectroscopies, and had their crystalline structures determined by X-ray diffractometry from single crystals. The monoanionic thiosemicarbazonate ligands act in a tridentate mode, binding to the metal through the pyridine nitrogen, the azomethine nitrogen and the sulfur atoms. The cytotoxic activity against the breast cancer cell line MDA-MB231 and the anti-Mycobacterium tuberculosis H37Rv ATCC 27294 activity were evaluated for the compounds. All PdII complexes were highly active against the studied cell line, presenting similar values of IC50, around 5 µmol L-1, while the clinically applied antitumor agent cisplatin was inactive. The compounds show remarkable anti-M. tuberculosis activities, presenting MIC values comparable or better than some commercial anti-M tuberculosis drugs. |