Development and validation of an UV-derivative spectrophotometric method for determination of glimepiride in tablets
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of the Brazilian Chemical Society (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532011000200015 |
Resumo: | Glimepiride is an oral antidiabetic drug widely used in treatment of type 2 diabetes. This work proposed the development and validation of a derivative UV spectrophotometric method for determination of glimepiride in tablets. The quantification of glimepiride in 5×10-3 mol L-1 NaOH was performed by using a wavelength interval of 8 nm in the range of 220-300 nm. The amplitude values obtained in the second-derivative spectra were arbitrary units of the peak height from the central zero base line to the signals obtained at 279.0, 257.5 and 256.3 nm for quantification of Amaryl® tablets 1 mg, Amaryl® tablets 2 mg and Amaryl® tablets 4 mg, respectively. The method was completely validated according to the International Conference on Harmonization (ICH) guidelines, showing accuracy, precision, selectivity, robustness and linearity. The validated method is suitable for quality control applications, since it does not use polluting reagents, it is simple and has low-cost. |
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Development and validation of an UV-derivative spectrophotometric method for determination of glimepiride in tabletsglimepiridevalidation of pharmaceutical methodsderivative-UV spectrophotometrypharmaceutical quality controlGlimepiride is an oral antidiabetic drug widely used in treatment of type 2 diabetes. This work proposed the development and validation of a derivative UV spectrophotometric method for determination of glimepiride in tablets. The quantification of glimepiride in 5×10-3 mol L-1 NaOH was performed by using a wavelength interval of 8 nm in the range of 220-300 nm. The amplitude values obtained in the second-derivative spectra were arbitrary units of the peak height from the central zero base line to the signals obtained at 279.0, 257.5 and 256.3 nm for quantification of Amaryl® tablets 1 mg, Amaryl® tablets 2 mg and Amaryl® tablets 4 mg, respectively. The method was completely validated according to the International Conference on Harmonization (ICH) guidelines, showing accuracy, precision, selectivity, robustness and linearity. The validated method is suitable for quality control applications, since it does not use polluting reagents, it is simple and has low-cost.Sociedade Brasileira de Química2011-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532011000200015Journal of the Brazilian Chemical Society v.22 n.2 2011reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532011000200015info:eu-repo/semantics/openAccessBonfilio,RudyAraújo,Magali B. deSalgado,Hérida R. Neng2011-02-14T00:00:00Zoai:scielo:S0103-50532011000200015Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2011-02-14T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
Development and validation of an UV-derivative spectrophotometric method for determination of glimepiride in tablets |
title |
Development and validation of an UV-derivative spectrophotometric method for determination of glimepiride in tablets |
spellingShingle |
Development and validation of an UV-derivative spectrophotometric method for determination of glimepiride in tablets Bonfilio,Rudy glimepiride validation of pharmaceutical methods derivative-UV spectrophotometry pharmaceutical quality control |
title_short |
Development and validation of an UV-derivative spectrophotometric method for determination of glimepiride in tablets |
title_full |
Development and validation of an UV-derivative spectrophotometric method for determination of glimepiride in tablets |
title_fullStr |
Development and validation of an UV-derivative spectrophotometric method for determination of glimepiride in tablets |
title_full_unstemmed |
Development and validation of an UV-derivative spectrophotometric method for determination of glimepiride in tablets |
title_sort |
Development and validation of an UV-derivative spectrophotometric method for determination of glimepiride in tablets |
author |
Bonfilio,Rudy |
author_facet |
Bonfilio,Rudy Araújo,Magali B. de Salgado,Hérida R. N |
author_role |
author |
author2 |
Araújo,Magali B. de Salgado,Hérida R. N |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Bonfilio,Rudy Araújo,Magali B. de Salgado,Hérida R. N |
dc.subject.por.fl_str_mv |
glimepiride validation of pharmaceutical methods derivative-UV spectrophotometry pharmaceutical quality control |
topic |
glimepiride validation of pharmaceutical methods derivative-UV spectrophotometry pharmaceutical quality control |
description |
Glimepiride is an oral antidiabetic drug widely used in treatment of type 2 diabetes. This work proposed the development and validation of a derivative UV spectrophotometric method for determination of glimepiride in tablets. The quantification of glimepiride in 5×10-3 mol L-1 NaOH was performed by using a wavelength interval of 8 nm in the range of 220-300 nm. The amplitude values obtained in the second-derivative spectra were arbitrary units of the peak height from the central zero base line to the signals obtained at 279.0, 257.5 and 256.3 nm for quantification of Amaryl® tablets 1 mg, Amaryl® tablets 2 mg and Amaryl® tablets 4 mg, respectively. The method was completely validated according to the International Conference on Harmonization (ICH) guidelines, showing accuracy, precision, selectivity, robustness and linearity. The validated method is suitable for quality control applications, since it does not use polluting reagents, it is simple and has low-cost. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-02-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532011000200015 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532011000200015 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0103-50532011000200015 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Journal of the Brazilian Chemical Society v.22 n.2 2011 reponame:Journal of the Brazilian Chemical Society (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Journal of the Brazilian Chemical Society (Online) |
collection |
Journal of the Brazilian Chemical Society (Online) |
repository.name.fl_str_mv |
Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
||office@jbcs.sbq.org.br |
_version_ |
1750318171901919232 |