Synthesis and Antileishmanial Activity of Some Functionalized Peptoids
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , |
Tipo de documento: | Relatório |
Idioma: | eng |
Título da fonte: | Journal of the Brazilian Chemical Society (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532019000601334 |
Resumo: | We describe the microwave-assisted synthesis of thirteen functionalized peptoids and evaluate their in vitro antileishmanial activity against forms of Leishmania (Leishmania) amazonensis promastigotes. Synthesis via the Ugi four-component reaction (Ugi 4CR) reaction furnished the compounds of interest in 55-80% yield; reactions were conducted in a microwave reactor and lasted only 10 min. We then screened the antileishmanial activity of the synthesized compounds in vitro. To determine the IC50 (inhibitory concentration necessary to inhibit the growth of 50% of parasites) values, we selected the compounds that inhibited L. (L.) amazonensis growth by more than 50%. The seven selected compounds displayed IC50 values ranging from 2.6 to 72 µM after incubation for 48 h. Three peptoids gave IC50 values between 2.6 and 7.9 µM and can be considered as bioreactive molecules (hit criteria). |
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Synthesis and Antileishmanial Activity of Some Functionalized Peptoidspeptoidmulticomponent reactionUgi reactionmicrowave-assisted synthesisLeishmania (Leishmania) amazonensisWe describe the microwave-assisted synthesis of thirteen functionalized peptoids and evaluate their in vitro antileishmanial activity against forms of Leishmania (Leishmania) amazonensis promastigotes. Synthesis via the Ugi four-component reaction (Ugi 4CR) reaction furnished the compounds of interest in 55-80% yield; reactions were conducted in a microwave reactor and lasted only 10 min. We then screened the antileishmanial activity of the synthesized compounds in vitro. To determine the IC50 (inhibitory concentration necessary to inhibit the growth of 50% of parasites) values, we selected the compounds that inhibited L. (L.) amazonensis growth by more than 50%. The seven selected compounds displayed IC50 values ranging from 2.6 to 72 µM after incubation for 48 h. Three peptoids gave IC50 values between 2.6 and 7.9 µM and can be considered as bioreactive molecules (hit criteria).Sociedade Brasileira de Química2019-06-01info:eu-repo/semantics/reportinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532019000601334Journal of the Brazilian Chemical Society v.30 n.6 2019reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.21577/0103-5053.20190023info:eu-repo/semantics/openAccessPrevidi,DanielRodrigues,StephanieCoelho,Mike G.Candido,Ana Carolina B. B.Magalhães,Lizandra G.Donate,Paulo M.eng2019-05-20T00:00:00Zoai:scielo:S0103-50532019000601334Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2019-05-20T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
Synthesis and Antileishmanial Activity of Some Functionalized Peptoids |
title |
Synthesis and Antileishmanial Activity of Some Functionalized Peptoids |
spellingShingle |
Synthesis and Antileishmanial Activity of Some Functionalized Peptoids Previdi,Daniel peptoid multicomponent reaction Ugi reaction microwave-assisted synthesis Leishmania (Leishmania) amazonensis |
title_short |
Synthesis and Antileishmanial Activity of Some Functionalized Peptoids |
title_full |
Synthesis and Antileishmanial Activity of Some Functionalized Peptoids |
title_fullStr |
Synthesis and Antileishmanial Activity of Some Functionalized Peptoids |
title_full_unstemmed |
Synthesis and Antileishmanial Activity of Some Functionalized Peptoids |
title_sort |
Synthesis and Antileishmanial Activity of Some Functionalized Peptoids |
author |
Previdi,Daniel |
author_facet |
Previdi,Daniel Rodrigues,Stephanie Coelho,Mike G. Candido,Ana Carolina B. B. Magalhães,Lizandra G. Donate,Paulo M. |
author_role |
author |
author2 |
Rodrigues,Stephanie Coelho,Mike G. Candido,Ana Carolina B. B. Magalhães,Lizandra G. Donate,Paulo M. |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Previdi,Daniel Rodrigues,Stephanie Coelho,Mike G. Candido,Ana Carolina B. B. Magalhães,Lizandra G. Donate,Paulo M. |
dc.subject.por.fl_str_mv |
peptoid multicomponent reaction Ugi reaction microwave-assisted synthesis Leishmania (Leishmania) amazonensis |
topic |
peptoid multicomponent reaction Ugi reaction microwave-assisted synthesis Leishmania (Leishmania) amazonensis |
description |
We describe the microwave-assisted synthesis of thirteen functionalized peptoids and evaluate their in vitro antileishmanial activity against forms of Leishmania (Leishmania) amazonensis promastigotes. Synthesis via the Ugi four-component reaction (Ugi 4CR) reaction furnished the compounds of interest in 55-80% yield; reactions were conducted in a microwave reactor and lasted only 10 min. We then screened the antileishmanial activity of the synthesized compounds in vitro. To determine the IC50 (inhibitory concentration necessary to inhibit the growth of 50% of parasites) values, we selected the compounds that inhibited L. (L.) amazonensis growth by more than 50%. The seven selected compounds displayed IC50 values ranging from 2.6 to 72 µM after incubation for 48 h. Three peptoids gave IC50 values between 2.6 and 7.9 µM and can be considered as bioreactive molecules (hit criteria). |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/report |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
report |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532019000601334 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532019000601334 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.21577/0103-5053.20190023 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Journal of the Brazilian Chemical Society v.30 n.6 2019 reponame:Journal of the Brazilian Chemical Society (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Journal of the Brazilian Chemical Society (Online) |
collection |
Journal of the Brazilian Chemical Society (Online) |
repository.name.fl_str_mv |
Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
||office@jbcs.sbq.org.br |
_version_ |
1750318181775310848 |