Biotransformation of a tetrahydrofuran lignan by the endophytic fungus Phomopsis Sp.

• Autor(a) principal: Verza,Michelle
• Data de Publicação: 2009
• Outros Autores: Arakawa,Nilton S., Lopes,Norberto P., Kato,Massuo J., Pupo,Mônica T., Said,Suraia, Carvalho,Ivone
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Journal of the Brazilian Chemical Society (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532009000100029
• topic: biotransformation; 2,5-diaryltetrahydrofuran; endophytic fungus; (-)-grandisin; trypanocidal activity

The biotrasformation of the tetrahydrofuran lignan, (-)-grandisin, by the endophitic fungus Phomopsis sp, obtained from Viguiera arenaria, led to the formation of a new compound determined as 3,4-dimethyl-2-(4'-hydroxy-3',5'-dimethoxyphenyl)-5-methoxy-tetrahydrofuran. The metabolite was evaluated against the parasite Trypanosoma cruzi, the causative agent of Chagas's disease, and showed a trypanocidal activity (IC50 9.8 μmol L-1) similar to the natural precursor (IC50 3.7 μmol L-1).