Local intersection volume (LIV) descriptors: 3D-QSAR models for PGI2 receptor ligands

Detalhes bibliográficos
Autor(a) principal: Martins,Rita C. A.
Data de Publicação: 2002
Outros Autores: Albuquerque,Magaly G., Alencastro,Ricardo B.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532002000600014
Resumo: Prostacyclin I2 inhibits platelet aggregation through specific binding to its membrane receptor. In this work, we developed 3D-QSAR models for a series of aromatic heterocyclic compounds from literature using the local intersection volume descriptor. The models obtained can be applied to design new PGI2 receptor ligands with potential platelet anti-aggregating activity.
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spelling Local intersection volume (LIV) descriptors: 3D-QSAR models for PGI2 receptor ligands3D-QSARlocal intersection volume (LIV)prostacyclin receptorplatelet aggregationProstacyclin I2 inhibits platelet aggregation through specific binding to its membrane receptor. In this work, we developed 3D-QSAR models for a series of aromatic heterocyclic compounds from literature using the local intersection volume descriptor. The models obtained can be applied to design new PGI2 receptor ligands with potential platelet anti-aggregating activity.Sociedade Brasileira de Química2002-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532002000600014Journal of the Brazilian Chemical Society v.13 n.6 2002reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532002000600014info:eu-repo/semantics/openAccessMartins,Rita C. A.Albuquerque,Magaly G.Alencastro,Ricardo B.eng2015-11-26T00:00:00Zoai:scielo:S0103-50532002000600014Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2015-11-26T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Local intersection volume (LIV) descriptors: 3D-QSAR models for PGI2 receptor ligands
title Local intersection volume (LIV) descriptors: 3D-QSAR models for PGI2 receptor ligands
spellingShingle Local intersection volume (LIV) descriptors: 3D-QSAR models for PGI2 receptor ligands
Martins,Rita C. A.
3D-QSAR
local intersection volume (LIV)
prostacyclin receptor
platelet aggregation
title_short Local intersection volume (LIV) descriptors: 3D-QSAR models for PGI2 receptor ligands
title_full Local intersection volume (LIV) descriptors: 3D-QSAR models for PGI2 receptor ligands
title_fullStr Local intersection volume (LIV) descriptors: 3D-QSAR models for PGI2 receptor ligands
title_full_unstemmed Local intersection volume (LIV) descriptors: 3D-QSAR models for PGI2 receptor ligands
title_sort Local intersection volume (LIV) descriptors: 3D-QSAR models for PGI2 receptor ligands
author Martins,Rita C. A.
author_facet Martins,Rita C. A.
Albuquerque,Magaly G.
Alencastro,Ricardo B.
author_role author
author2 Albuquerque,Magaly G.
Alencastro,Ricardo B.
author2_role author
author
dc.contributor.author.fl_str_mv Martins,Rita C. A.
Albuquerque,Magaly G.
Alencastro,Ricardo B.
dc.subject.por.fl_str_mv 3D-QSAR
local intersection volume (LIV)
prostacyclin receptor
platelet aggregation
topic 3D-QSAR
local intersection volume (LIV)
prostacyclin receptor
platelet aggregation
description Prostacyclin I2 inhibits platelet aggregation through specific binding to its membrane receptor. In this work, we developed 3D-QSAR models for a series of aromatic heterocyclic compounds from literature using the local intersection volume descriptor. The models obtained can be applied to design new PGI2 receptor ligands with potential platelet anti-aggregating activity.
publishDate 2002
dc.date.none.fl_str_mv 2002-11-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532002000600014
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532002000600014
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-50532002000600014
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.13 n.6 2002
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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