A Self-Assembled AMF-Responsive Nanoplatform Based on Pillar[5]arene and Superparamagnetic Nanoparticles for Controlled Release of Doxorubicin
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of the Brazilian Chemical Society (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532019001102452 |
Resumo: | An alternating magnetic field (AMF)-stimuli responsive nanodevice based on magnetic nanoparticles (MNP) functionalized with water-soluble carboxylate-substituted pillar[5]arene (CP[5]A), namely MNP-CP[5]A, as a multiplatform for cancer treatment has been designed. MNP-CP[5]A was loaded with doxorubicin (DOX), showing a loading capacity of 9.5 mg g-1. The nanodevice demonstrated good colloidal stability, superparamagnetic behavior, and was capable to generate detectable heat in solution induced by AMF application. DOX release, monitored by ultraviolet-visible (UV-Vis) spectroscopy, was investigated by varying the temperature (37 and 45 °C) without AMF and in the presence of AMF (frequency (f) = 307 kHz, field amplitude (H) = 200 Oe, 45 °C) at pH = 7.4. Thermo-induced DOX release without AMF was 1.9% (1.8 μg mL-1) and 2.3% (3.3 μg mL-1) at 37, and 45 °C within 50 min, respectively. In an AMF DOX release increased to 5.7% (8.2 μg mL-1) within 50 min. Therefore, MNP-CP[5]A-DOX works as a chemo-hyperthermia nanodevice. |
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Journal of the Brazilian Chemical Society (Online) |
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A Self-Assembled AMF-Responsive Nanoplatform Based on Pillar[5]arene and Superparamagnetic Nanoparticles for Controlled Release of Doxorubicincarboxylate-substituted pillar[5]arenesuperparamagnetic nanoparticlesmagnetic hyperthermiadoxorubicin deliverycancerAn alternating magnetic field (AMF)-stimuli responsive nanodevice based on magnetic nanoparticles (MNP) functionalized with water-soluble carboxylate-substituted pillar[5]arene (CP[5]A), namely MNP-CP[5]A, as a multiplatform for cancer treatment has been designed. MNP-CP[5]A was loaded with doxorubicin (DOX), showing a loading capacity of 9.5 mg g-1. The nanodevice demonstrated good colloidal stability, superparamagnetic behavior, and was capable to generate detectable heat in solution induced by AMF application. DOX release, monitored by ultraviolet-visible (UV-Vis) spectroscopy, was investigated by varying the temperature (37 and 45 °C) without AMF and in the presence of AMF (frequency (f) = 307 kHz, field amplitude (H) = 200 Oe, 45 °C) at pH = 7.4. Thermo-induced DOX release without AMF was 1.9% (1.8 μg mL-1) and 2.3% (3.3 μg mL-1) at 37, and 45 °C within 50 min, respectively. In an AMF DOX release increased to 5.7% (8.2 μg mL-1) within 50 min. Therefore, MNP-CP[5]A-DOX works as a chemo-hyperthermia nanodevice.Sociedade Brasileira de Química2019-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532019001102452Journal of the Brazilian Chemical Society v.30 n.11 2019reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.21577/0103-5053.20190164info:eu-repo/semantics/openAccessFernandes,Tamires S.Santos,Evelyn C. S.Madriaga,Vinicius G. C.Bessa,Isabela A. A.Nascimento,VanessaGarcia,FlávioRonconi,Célia M.eng2019-10-18T00:00:00Zoai:scielo:S0103-50532019001102452Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2019-10-18T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
A Self-Assembled AMF-Responsive Nanoplatform Based on Pillar[5]arene and Superparamagnetic Nanoparticles for Controlled Release of Doxorubicin |
title |
A Self-Assembled AMF-Responsive Nanoplatform Based on Pillar[5]arene and Superparamagnetic Nanoparticles for Controlled Release of Doxorubicin |
spellingShingle |
A Self-Assembled AMF-Responsive Nanoplatform Based on Pillar[5]arene and Superparamagnetic Nanoparticles for Controlled Release of Doxorubicin Fernandes,Tamires S. carboxylate-substituted pillar[5]arene superparamagnetic nanoparticles magnetic hyperthermia doxorubicin delivery cancer |
title_short |
A Self-Assembled AMF-Responsive Nanoplatform Based on Pillar[5]arene and Superparamagnetic Nanoparticles for Controlled Release of Doxorubicin |
title_full |
A Self-Assembled AMF-Responsive Nanoplatform Based on Pillar[5]arene and Superparamagnetic Nanoparticles for Controlled Release of Doxorubicin |
title_fullStr |
A Self-Assembled AMF-Responsive Nanoplatform Based on Pillar[5]arene and Superparamagnetic Nanoparticles for Controlled Release of Doxorubicin |
title_full_unstemmed |
A Self-Assembled AMF-Responsive Nanoplatform Based on Pillar[5]arene and Superparamagnetic Nanoparticles for Controlled Release of Doxorubicin |
title_sort |
A Self-Assembled AMF-Responsive Nanoplatform Based on Pillar[5]arene and Superparamagnetic Nanoparticles for Controlled Release of Doxorubicin |
author |
Fernandes,Tamires S. |
author_facet |
Fernandes,Tamires S. Santos,Evelyn C. S. Madriaga,Vinicius G. C. Bessa,Isabela A. A. Nascimento,Vanessa Garcia,Flávio Ronconi,Célia M. |
author_role |
author |
author2 |
Santos,Evelyn C. S. Madriaga,Vinicius G. C. Bessa,Isabela A. A. Nascimento,Vanessa Garcia,Flávio Ronconi,Célia M. |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Fernandes,Tamires S. Santos,Evelyn C. S. Madriaga,Vinicius G. C. Bessa,Isabela A. A. Nascimento,Vanessa Garcia,Flávio Ronconi,Célia M. |
dc.subject.por.fl_str_mv |
carboxylate-substituted pillar[5]arene superparamagnetic nanoparticles magnetic hyperthermia doxorubicin delivery cancer |
topic |
carboxylate-substituted pillar[5]arene superparamagnetic nanoparticles magnetic hyperthermia doxorubicin delivery cancer |
description |
An alternating magnetic field (AMF)-stimuli responsive nanodevice based on magnetic nanoparticles (MNP) functionalized with water-soluble carboxylate-substituted pillar[5]arene (CP[5]A), namely MNP-CP[5]A, as a multiplatform for cancer treatment has been designed. MNP-CP[5]A was loaded with doxorubicin (DOX), showing a loading capacity of 9.5 mg g-1. The nanodevice demonstrated good colloidal stability, superparamagnetic behavior, and was capable to generate detectable heat in solution induced by AMF application. DOX release, monitored by ultraviolet-visible (UV-Vis) spectroscopy, was investigated by varying the temperature (37 and 45 °C) without AMF and in the presence of AMF (frequency (f) = 307 kHz, field amplitude (H) = 200 Oe, 45 °C) at pH = 7.4. Thermo-induced DOX release without AMF was 1.9% (1.8 μg mL-1) and 2.3% (3.3 μg mL-1) at 37, and 45 °C within 50 min, respectively. In an AMF DOX release increased to 5.7% (8.2 μg mL-1) within 50 min. Therefore, MNP-CP[5]A-DOX works as a chemo-hyperthermia nanodevice. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-11-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532019001102452 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532019001102452 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.21577/0103-5053.20190164 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Journal of the Brazilian Chemical Society v.30 n.11 2019 reponame:Journal of the Brazilian Chemical Society (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Journal of the Brazilian Chemical Society (Online) |
collection |
Journal of the Brazilian Chemical Society (Online) |
repository.name.fl_str_mv |
Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
||office@jbcs.sbq.org.br |
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1750318182488342528 |