Citotoxicity and immune response induced by organopalladium(II) compounds in mice bearing Ehrlich ascites tumour

• Autor(a) principal: Rocha,Michelle C. da
• Data de Publicação: 2007
• Outros Autores: Santana,Anderson M., Ananias,Sandra R., Almeida,Eduardo T. de, Mauro,Antonio E., Placeres,Marisa C. P., Carlos,Iracilda Z.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Journal of the Brazilian Chemical Society (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532007000800004
• topic: palladium(II) complexes; Ehrlich ascites tumour; macrophages; nitric oxide; tumour necrosis factor-alpha

Cyclometallated palladium(II) complexes are reactive inorganic compounds employed in several biological studies because of their antitumour potential and interaction with immune system. In the present study, the immune and citotoxic response induced by two organopalladated complexes: [{Pd(N,C-dmba)}2(µ-NCS)2 ] (1), [Pd(C-dmba)(NCS)(dppp)] (2) [dmba = N,N'dimethylbenzylamine, dppp = 1,3-bis(diphenylphosphino)propane] and cisplatin (cis-DDP), as standard, were investigated in mice bearing Ehrlich ascites tumour. The mice were divided into five groups and inoculated with the compounds (1) or (2) or cisplatin, or only vehicle or phosphate-buffered saline (PBS). Many parameters were evaluated, such as tumour cell percentage in the peritoneal exsudate, levels of seric nitric oxide (NO) and tumour necrosis factor-alpha (TNF-alpha) and increase in life span. Analysis of all data revealed, for compound (2), an activity similar to that presented by cisplatin, resulting in increased life span, lower levels of seric TNF-alpha and increase in NO production.